Association of abnormal white matter integrity in the acute phase of motor vehicle accidents with post-traumatic stress disorder

Hu, Hao; Zhou, Yan; Wang, Qian; Su, Shanshan; Qiu, Yongming; Ge, Jian; Wang, Zhen; Xiao, Zeping

doi:10.1016/j.jad.2015.09.044

Cited by 34 publications

(37 citation statements)

References 59 publications

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“…Here we report microstructural evidence that structural connectivity between the left and right hippocampus may also be disrupted in PTSD. While many studies have reported that PTSD is associated with alterations in the cingulum bundle [9][10][11][12][13]16,18,21,[23][24][25][26][27][28][29]31,32,36 , which has a hippocampal component, the tapetum has not yet emerged for several possible reasons. Many prior studies took an ROI approach, which limited analyses to pre-determined regions that frequently omitted the tapetum, a small region often grouped with other tracts such as the splenium or posterior thalamic radiation.…”

Section: Discussionmentioning

confidence: 99%

“…The female and civilian subgroups were smaller and therefore the analyses had lower power than in male and military subgroups. Most prior dMRI studies in civilians report lower FA in PTSD 9,10,[12][13][14]16,17,[21][22][23][24][25][30][31][32]67 . Studies of military cohorts have been mixed, reporting higher FA [26][27][28][29]36 , lower FA 8,15,[18][19][20] , and null results [33][34][35] .…”

Section: Discussionmentioning

confidence: 99%

“…Studies of white matter microstructure in PTSD have reported inconsistent results. The majority report that PTSD is associated with lower FA [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] , but some report higher FA [25][26][27][28][29][30][31] , higher and lower FA in different regions 32 , or null results [33][34][35] .…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in the cingulum bundle are frequently reported [9][10][11][12][13]16,18,21,[23][24][25][26][27][28][29]31,32,36 , with differences also observed in the uncinate, corpus callosum, and corona radiata 14,16,18,19,24,26,29 . Inconsistent findings may be partially due to the use of hypothesis-driven rather than whole brain approaches, choice of analytic pipeline, selection of diffusion metrics, gender-specific studies, homogeneity of single cohort samples such as trauma-exposed vs. unexposed controls, and focus on military vs. civilian samples.…”

Section: Introductionmentioning

confidence: 99%

“…The ENIGMA DTI workflow 38 , which has successfully identified white matter compromise in schizophrenia 39 , bipolar disorder 40 , major depression 41 , and 22q11.2 deletion syndrome 42 , among others, was used by 28 cohorts to process their DTI data locally. We hypothesized the largest effects of compromised microstructure will be evident in the fronto-limbic tracts, such as the cingulum, uncinate, fornix, and corpus callosum; these tracts are strongly implicated in behavioral deficits of PTSD such as emotion regulation, working memory, and episodic memory 10,16,19,20,24,43 .…”

Section: Introductionmentioning

confidence: 99%

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Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

Dennis

Disner

Fani

et al. 2019

Preprint

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A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed, which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3,049 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1,446 individuals with PTSD and 1,603 controls (2152 males/897 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d=-0.12, p=0.0021). The tapetum connects the left and right hippocampus, structures for which structure and function have been consistently implicated in PTSD. Results remained significant/similar after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

Dennis

Disner

Fani

et al. 2019

Preprint

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Mild Traumatic Brain Injury and Posttraumatic Stress Disorder

Bolzenius

2020

The Wiley Encyclopedia of Health Psychology

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Psychoradiological abnormalities in treatment‐naive noncomorbid patients with posttraumatic stress disorder

Suo

Lei

et al. 2021

Depression and Anxiety

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Background: Neuroimaging studies in posttraumatic stress disorder (PTSD) have identified various alterations in white matter (WM) microstructural organization.However, it remains unclear whether these are localized to specific regions of fiber tracts, and what diagnostic value they might have. This study set out to explore the spatial profile of WM abnormalities along defined fiber tracts in PTSD.Methods: Diffusion tensor images were obtained from 77 treatment-naive noncomorbid patients with PTSD and 76 demographically matched trauma-exposed non-PTSD (TENP) controls. Using automated fiber quantification, tract profiles of fractional anisotropy, axial diffusivity, mean diffusivity, and radial diffusivity were calculated to evaluate WM microstructural organization. Results were analyzed by pointwise comparisons, by correlation with symptom severity, and for diagnosis-bysex interactions. Support vector machine analyses assessed the ability of tract profiles to discriminate PTSD from TENP.Results: Compared to TENP, PTSD showed lower fractional anisotropy accompanied by higher radial diffusivity and mean diffusivity in the left uncinate fasciculus, and lower fractional anisotropy accompanied by higher radial diffusivity in the right anterior thalamic radiation. Tract profile alterations were correlated with symptom severity, suggesting a pathophysiological relevance. There were no significant differences in diagnosis-by-sex interaction. Tract profiles allowed individual classification of PTSD versus TENP with significant accuracy, of potential diagnostic utility.Conclusions: These findings add to the knowledge of the neuropathological basis of PTSD. WM alterations based on a tract-profile quantification approach are a potential biomarker for PTSD.

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Association of abnormal white matter integrity in the acute phase of motor vehicle accidents with post-traumatic stress disorder

Cited by 34 publications

References 59 publications

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

Mild Traumatic Brain Injury and Posttraumatic Stress Disorder

Psychoradiological abnormalities in treatment‐naive noncomorbid patients with posttraumatic stress disorder

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