Association of ABO and RhD blood groups with the risk of HIV infection

Jacobs, Genevieve; Berg, Karin van den; Vermeulen, Marion; Swanevelder, Ronél; Custer, Brian; Murphy, Edward L.

doi:10.1371/journal.pone.0284975

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…The prevalence of HIV was highest in Afollowed by AB -. This observation opposed the study by Jacobs et al [1,19] which demonstrated higher prevalence in Rhesus positive individual [20]. 8) 13 ( 13) 15 ( 24) 33 ( 11) 27 ( 6) 18 ( 12) 43 ( 14) 38 ( 16) 14 ( 5) 35-45 1 (1) 10 ( 6) 1 ( 1) 5 ( 8) Finally, this study contributes to our understanding of the sero-prevalence of HIV among students undergoing medical examination in a tertiary institution.…”

Section: Discussioncontrasting

confidence: 82%

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Sero-prevalence of Human Immunodeficiency Virus among Students Undergoing Medical Examination in a Tertiary Institution

Huldah,

Renner

2024

Int. STD Res. Rev.

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Aims: To assess the prevalence of human immunodeficiency virus among students undergoing medical checkup in a tertiary institution. Study Design: The investigation utilised a cross-sectional study design technique. Methodology: In this present study, 2114 participants were included in the age range 15-49 years. Serological method was used to detect the presence of HIV using a rapid diagnostic technique using determine. Tile method was used to determine the ABO and Rhesus D antigens in the individuals. Results: Out of the 2114 participants sampled, the population studied according to various departments within the university were ME 95 (5%), EM 181 (9%), LIB 101 (5%), SPE 63 (3%), ENG 296 (14%), BIO 423 (20%), CHE 150 (7%), COM 305 (14%), MGT 236 (11%) and ACC 236 (12%). The prevalence of HIV among tertiary institution students is 1%. Conclusion: This research gives an insight into the prevalence of HIV among students in tertiary institution for strategic intervention.

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Section: Discussioncontrasting

confidence: 82%

“…The human immunodeficiency virus (HIV) is a chronic viral infectious disease that damages the immune system of the infected individual. It progresses to the development of Acquired Immune Deficiency Syndrome (AIDS) and death without proper medical attention [1]. It is an enveloped lentivirus within the family Retroviridae.…”

Section: Introductionmentioning

confidence: 99%

Sero-prevalence of Human Immunodeficiency Virus among Students Undergoing Medical Examination in a Tertiary Institution

Huldah,

Renner

2024

Int. STD Res. Rev.

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“…The results suggested that the ABO blood group was not related to HIV infection. However, the point estimate for OR assesses blood group AB and HIV infection is 1.03 [ 83 ]. Cross-sectional studies cannot be used to infer causality and potential biases should be considered in the observational studies.…”

Section: Discussionmentioning

confidence: 99%

ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

Liu,

Guo,

Xing

et al. 2024

BMC Med

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Background Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associations is still lacking. Methods We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes. For each association, we calculated the summary effect sizes, corresponding 95% confidence intervals, 95% prediction interval, heterogeneity, small-study effect, and evaluation of excess significance bias. The evidence was evaluated on a grading scale that ranged from convincing (Class I) to weak (Class IV). We assessed the certainty of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation criteria (GRADE). We also evaluated the methodological quality of included studies using the A Measurement Tool to Assess Systematic Reviews (AMSTAR). AMSTAR contains 11 items, which were scored as high (8–11), moderate (4–7), and low (0–3) quality. We have gotten the registration for protocol on the PROSPERO database (CRD42023409547). Results The current umbrella review included 51 systematic reviews with meta-analysis articles with 270 associations. We re-calculated each association and found only one convincing evidence (Class I) for an association between blood group B and type 2 diabetes mellitus risk compared with the non-B blood group. It had a summary odds ratio of 1.28 (95% confidence interval: 1.17, 1.40), was supported by 6870 cases with small heterogeneity (I2 = 13%) and 95% prediction intervals excluding the null value, and without hints of small-study effects (P for Egger’s test > 0.10, but the largest study effect was not more conservative than the summary effect size) or excess of significance (P < 0.10, but the value of observed less than expected). And the article was demonstrated with high methodological quality using AMSTAR (score = 9). According to AMSTAR, 18, 32, and 11 studies were categorized as high, moderate, and low quality, respectively. Nine statistically significant associations reached moderate quality based on GRADE. Conclusions Our findings suggest a potential relationship between ABO and Rh blood groups and adverse health outcomes. Particularly the association between blood group B and type 2 diabetes mellitus risk.

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“… 27 Meanwhile, a study from South Africa reported a weak association between Rh-D positive and HIV, and no association of ABO blood type association with TTIs. 30 In a study carried out by Arif et al, 31 AB/Rh-positive blood group was associated with syphilis infection. Still others demonstrated no significant association between ABO and TTIs.…”

Section: Discussionmentioning

confidence: 96%

Association of ABO, Rh-D and Kell blood groups with transfusion transmitted infections among blood donors from the Asir Region, Saudi Arabia

Shaikh,

Alqasem,

Alshubruqi

et al. 2024

SMJ

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Objectives: To evaluate the association between transfusion-transmitted infections (TTIs) and ABO, Rh-D, and Kell blood systems among blood donors. Methods: This was a retrospective study of 10,095 donors who visited the Blood Bank at Asir Hospital, Abha, Saudi Arabia. Data including demographic information, ABO, Rh-D, and Kell blood groups, and serological and molecular test results of TTIs (the TTIs were obtained from each donor’s records). Chi-squared and Fisher’s exact tests were employed to establish possible associations between blood groups and TTIs. Results: The prevalence rate of TTIs among donors was 6.3%, with HBcAb (70%) being the most prevalent biomarker among positive donors. Donors with the O blood group were at a higher risk of contracting TTIs. Significant associations were observed between HIV and blood group A (χ 2 =6.30, p =0.01), HBsAg and group AB (χ 2 =17.3193, p =0.00003), malaria and group A (χ 2 =5.0567, p =0.02), and HBV-DNA and group AB (χ 2 =12.3163, p =0.0004). Also, Kell blood group was significantly associated with HIV (χ 2 =14.5, p =0.0001), HBcAb (χ 2 =78.51, p <0.0001), and syphilis (χ 2 =25.225, p <0.00001). Conclusion: ABO and Kell blood groups are associated with TTI markers. These findings highlight the need for improved strategies and approaches in screening and managing blood donations to minimize the risk of TTIs.

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Association of ABO and RhD blood groups with the risk of HIV infection

Cited by 3 publications

References 18 publications

Sero-prevalence of Human Immunodeficiency Virus among Students Undergoing Medical Examination in a Tertiary Institution

Sero-prevalence of Human Immunodeficiency Virus among Students Undergoing Medical Examination in a Tertiary Institution

ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

Association of ABO, Rh-D and Kell blood groups with transfusion transmitted infections among blood donors from the Asir Region, Saudi Arabia

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