Association of ACE I/D, -240A &gt; T and AT1R A1166C polymorphisms with susceptibility to breast cancer: a systematic review and meta-analysis based on 35 case-control studies

Dastgheib, Seyed Alireza; Asadian, Fatemeh; Farbod, Meraj; Karimi-Zarchi, Mojgan; Meibodi, Bahare; Akbarian, Elahe; Neámatzadeh, Hossein

doi:10.1080/15257770.2020.1826515

Cited by 3 publications

(5 citation statements)

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“…As far as cancer development, progression and metastasis are associated with angiogenesis and proliferative processes, one may suppose that RAS could be related to cancer development. ACE is well known to be a key part of RAS, the polymorphisms especially I/D in ACE gene has been found to be associated with different diseases including cancer [24,25]. This study aimed to determine the association of the ACE I/D (rs1799752) gene polymorphism in breast cancer prediction risk in Egyptian population.…”

Section: Discussionmentioning

confidence: 97%

“…Some evidence suggests that the ACE I/D polymorphism is linked to an increased risk of breast cancer. ACE I/D has been linked to BC in general and by ethnicity [24,25], particularly among Asians and Caucasians [24,25]. To further validate the apparent association, welldesigned research with a bigger sample size and more ethnic groups are required.…”

Section: Discussionmentioning

confidence: 99%

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Is Angiotensin Converting Enzyme Insertion/Deletion (rs1799752) Polymorphism Associated with Breast Cancer Risk in Egyptian Population?

Essobky

Abdel-Megied

El-mezayen

et al. 2022

AJBGMB

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Background: According to GLOBOCAN estimates, breast cancer was found to be the most often diagnosed cancer in women worldwide, (11.7 %) and the fourth leading cause of cancer mortality (6.9 %). Aim: The purpose of this study is to investigate the role of the Angiotensin I-converting enzyme (ACE) gene polymorphism in breast cancer prediction risk in Egyptian population. Methods: Polymorphism detection analysis was performed on 163 subjects from breast cancer (BC) patients, 79 with Benign Breast Disease group (BBD) patients and 202 controls (C). ACE I/D (rs1799752) polymorphism were detected using polymerase chain reaction (PCR). Results: The observed genotype frequencies were II 10.9%, ID 78.2% and DD 10.9% in healthy control, II 8.6%, ID 79.1% and DD 12.3% in BC patients and II 12.6%, ID 78.4% and DD 9% in BBD patients. There were no association between ACE gene polymorphisms, between the BC or BBD groups when compared to the control group (ORDD= 1.43, 95 % CI= (0.58-3.52), P= 0.29) and (ORDD= 1.29, 95 % CI= (0.57-2.95), P= 0.37) respectively. There was no risk estimate in BC or BBD when DD vs II + ID (Recessive) or ID vs II+ DD (Over-dominant) were compared to control. Allele frequencies show the same figure. From the different histological BC hormonal markers the Her2 was showing significant association in ID genotype of ACE I/D (rs1799752) (P= 0.04) and dominant model (II vs ID + DD, P= 0.03). Concerning different BC prognostic models, the poor prognostic one of Her2 enriched model (ER-ve PR-ve Her2+ve) show significant association in ACE genotype ID and dominant model (II vs ID + DD), (P= 0.01) when compared to the good prognostic hormonal status. Conclusion: It seems that this is the first study that interested in correlate the ACE gene polymorphisms in different BC variants characters in Egyptian patients. ACE I/D (rs1799752) polymorphism ID genotype have strong association to breast cancer carcinogenesis, poor prognosis and metastasis. It may be used as practical biomarker to guide the BC carcinogenesis and risk process.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Is Angiotensin Converting Enzyme Insertion/Deletion (rs1799752) Polymorphism Associated with Breast Cancer Risk in Egyptian Population?

Essobky

Abdel-Megied

El-mezayen

et al. 2022

AJBGMB

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“…Previous studies showed that the D allele in the ACE gene polymorphism is associated with higher ACE levels 5 , 6 , meaning also high levels of the AT-2 and AT-2 type 1 receptors. In this context, the relationship between ACE I/D gene polymorphism and many solid cancer types was investigated in several studies 4 , 7 , 9 , 11-13 and it is worth investigating also for LC.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphism in patients with laryngeal cancer

Öztürk

Yasan

Akın

et al. 2023

Acta Otorhinolaryngol Ital

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SUMMARY Objectives The aim of this study was to compare the distribution of the angiotensin-converting enzyme (ACE) I/D polymorphism between patients with laryngeal cancer (LC) and a control group and to examine the distribution of this polymorphism with clinical parameters related to LC. Methods We enrolled 44 LC patients and 61 healthy controls. The ACE I/D polymorphism was genotyped with the PCR-RFLP method. The distribution of ACE genotypes (II, ID, and DD) and alleles (I or D) was evaluated with Pearson’s chi-square test, and logistic regression analysis was performed for statistically significant parameters. Results There was no significant difference in ACE genotypes and alleles between LC patients and controls (p = 0.079 and p = 0.068, respectively). Among clinical parameters related to LC (extension of tumour, node metastasis, tumour stage and tumour location), only the presence of node metastasis was found to be significant in terms of ACE DD genotype (p = 0.137, p = 0.031, p = 0.147, p = 0.321 respectively). In the logistic regression analysis, the ACE DD genotype was increased 8.3 fold in nodal metastases. Conclusions The findings of the study suggest that ACE genotypes and alleles do not affect the prevalence of LC, but the DD genotype of ACE polymorphism may increase the risk of lymph node metastasis in LC patients.

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“…Additionally, II and DD genotypes confer susceptibility to pancreatic cancer (PC) and chronic pancreatitis, respectively [101]. Regarding BC, the I allele carriers show a decreased risk [66,[102][103][104][105]. Those with the I allele have a greater expression of HER2 [106], while DD genotype carriers present a better disease-free survival rate [106,107].…”

Section: Angiotensin II (Ang Ii)mentioning

confidence: 99%

“…The ACE rs4291 (T>A) is an alteration in the promoter region referred to confer susceptibility to cancer in the Asian and Caucasian ethnic groups and specifically to BC in Latino populations [68,103]. This SNP seems to be in linkage disequilibrium (LD) with the ACE indel among women.…”

Section: Angiotensin II (Ang Ii)mentioning

confidence: 99%

Contribution of Endothelial Dysfunction to Cancer Susceptibility and Progression: A Comprehensive Narrative Review on the Genetic Risk Component

de Melo,

Tavares,

Pereira

et al. 2024

CIMB

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Venous thromboembolism (VTE) is a challenging clinical obstacle in oncological settings, marked by elevated incidence rates and resulting morbidity and mortality. In the context of cancer-associated thrombosis (CAT), endothelial dysfunction (ED) plays a crucial role in promoting a pro-thrombotic environment as endothelial cells lose their ability to regulate blood flow and coagulation. Moreover, emerging research suggests that this disorder may not only contribute to CAT but also impact tumorigenesis itself. Indeed, a dysfunctional endothelium may promote resistance to therapy and favour tumour progression and dissemination. While extensive research has elucidated the multifaceted mechanisms of ED pathogenesis, the genetic component remains a focal point of investigation. This comprehensive narrative review thus delves into the genetic landscape of ED and its potential ramifications on cancer progression. A thorough examination of genetic variants, specifically polymorphisms, within key genes involved in ED pathogenesis, namely eNOS, EDN1, ACE, AGT, F2, SELP, SELE, VWF, ICAM1, and VCAM1, was conducted. Overall, these polymorphisms seem to play a context-dependent role, exerting both oncogenic and tumour suppressor effects depending on the tumour and other environmental factors. In-depth studies are needed to uncover the mechanisms connecting these DNA variations to the pathogenesis of malignant diseases.

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Association of ACE I/D, -240A > T and AT1R A1166C polymorphisms with susceptibility to breast cancer: a systematic review and meta-analysis based on 35 case-control studies

Cited by 3 publications

References 38 publications

Is Angiotensin Converting Enzyme Insertion/Deletion (rs1799752) Polymorphism Associated with Breast Cancer Risk in Egyptian Population?

Is Angiotensin Converting Enzyme Insertion/Deletion (rs1799752) Polymorphism Associated with Breast Cancer Risk in Egyptian Population?

Angiotensin-converting enzyme insertion/deletion gene polymorphism in patients with laryngeal cancer

Contribution of Endothelial Dysfunction to Cancer Susceptibility and Progression: A Comprehensive Narrative Review on the Genetic Risk Component

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