Association of ACE ID and ACE G2350A polymorphism with increased blood pressure in persons exposed to different sound levels in Pakistan

Nawaz, Syed Kashif; Hasnain, Shahida

doi:10.1007/s00420-011-0619-6

Cited by 2 publications

(2 citation statements)

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“…A2350G, a silence substitution in exon 17 of ACE gene, was reported to be associated with plasma ACE concentration [31]. The SNP has been investigated to have an association with hypertension in Pakistani and Gulf populations [32,33].…”

Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

et al. 2014

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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with multiple genetic and environmental factors involving in its etiology. ACE and eNOS gene were considered to have important roles in the development and progression of DN. In this study, a case-control study was carried out to investigate the effects of 7 SNPs in ACE gene and 2 SNPs in eNOS gene in the development of DN in Northern China.7 SNPs including A240T, A2350G, A5466C, A2215G, T3892C, C1237T and C3409T of ACE gene and 2 SNPs (G894T and T786C) of eNOS gene were genotyped by polymerase chain reaction restriction fragment length polymorphism method. 431 type 2 diabetic patients with nephropathy (cases) were compared to 420 type 2 diabetic patients without nephropathy (controls) in the study. Data were analyzed by SPSS 17.0 and HaploView software. The frequency distribution of A2350G, 4 haplotyps in ACE gene and G894T in eNOS gene were demonstrated to be different between case and control groups significantly. Whereas other SNPs and haplotypes had no differences in two cohorts. The results revealed that variations of ACE and eNOS gene had association with DN, which indicated ACE and eNOS gene may play an important role in pathogenesis of DN in Northern Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

et al. 2014

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“…ACE G2350A polymorphism association with hypertension showed inconclusive results of either null or positive associations [50]. Another study revealed that in Muslims from the Arab Gulf and Pakistan the ACE 2350A allele is associated with significantly reduced hypertension while elevated risk among Chinese [51].…”

Section: Ace G2350a Polymorphismmentioning

confidence: 99%

The Risk for the Development of Diabetic Nephropathy: Interplay of Biochemical, Genetic, Nutritional and Lifestyle Factors

Shahid¹,

Jawed²

2024

Novel Topics in the Diagnosis, Treatment, and Follow-Up of Nephritis, Nephrotic Syndrome, and Nephrosis

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The recent unprecedented pandemic COVID-19 has blatantly exposed the healthcare system globally. The increasing rate of mortality and morbidity/co-morbidity were observed due to an interplay of COVID-19 infection with chronic diseases like diabetes, cancers, CVDs, respiratory and mental illness. According to World Health Organization, diabetes kills 1.7 million people annually. The prevalence and incidence of diabetes mellitus, representing >90% of all cases of diabetes and its complications, are increasing rapidly. The International Diabetes Federation has estimated that the number of people with diabetes is expected to rise from 366 million in 2011 to 552 million by 2030 if no urgent action is taken. Diabetes is a leading cause of kidney disease. About one in three adult diabetic patients has kidney disease, that is, diabetic nephropathy. In search for the risk and causes of diabetes and its complications such as diabetic nephropathy, research has now advanced to the molecular level. Genetics, epigenetics, genomics, proteomics, and metabolomics are opening ways to a new and deeper understanding of bodily processes and are providing the tools for more precisely targeted interventions when their function is disturbed. Similarly, tobacco use, physical inactivity, the harmful use of alcohol, and unhealthy diets all increase the risk of developing diabetic nephropathy. This chapter will focus on analyzing recently researched and published biochemical, genetic, nutritional, and lifestyle factors in various populations to ascertain the interplay of a wide variety of modifiable and non-modifiable factors, which will help delay and/or prevent the development of kidney disease in diabetes.

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Association of ACE ID and ACE G2350A polymorphism with increased blood pressure in persons exposed to different sound levels in Pakistan

Abstract: No association was observed between ACE ID/ACE G2350A polymorphism and the increased blood pressure in persons exposed to normal sound and noise in Pakistani population.

Cited by 2 publications

References 20 publications

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

The Risk for the Development of Diabetic Nephropathy: Interplay of Biochemical, Genetic, Nutritional and Lifestyle Factors

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