Association of acquired thrombotic thrombocytopaenic purpura in a patient with pernicious anaemia

Podder, Sidhertha; Cervates, Jose; Dey, Bimalangshu R.

doi:10.1136/bcr-2015-211989

Cited by 7 publications

(2 citation statements)

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“…The literature has described cases that differentiate TTP from pseudo-TTP. Pseudo-TTP is a phenomenon where pernicious anemia can mimic symptoms of TTP [ 4 , 11 , 12 ]. Several authors have presented similar cases of TTP as a rare presentation of pernicious anemia.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation

Aboona¹,

Rapaich²,

Etman³

et al. 2022

J Med Cases

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Pernicious anemia is an autoimmune disorder that is characterized by the presence of autoantibodies to intrinsic factor and parietal cells which results in the inability to absorb vitamin B12. It is the most common manifestation of vitamin B12 deficiency and accounts for 20-50% of cases. Disseminated intravascular coagulation (DIC) is a clinical condition that is a complication of another process which causes the activation of coagulation. A 63-year-old female with a history of hypothyroidism presented with a 1-month history of worsening fatigue, intermittent epigastric pain, nausea, vomiting, and diarrhea. Initial laboratory findings showed severe anemia and macrocytosis with a hemoglobin of 4.3 g/dL and a mean corpuscular volume (MCV) of 138 fL. There was also a significant elevation of the D-dimer, lactate dehydrogenase (LDH), and creatinine. She received three units of packed red blood cells (pRBCs) and fluid resuscitation. A vitamin B12 level was obtained which revealed a severe vitamin B12 deficiency (< 150 pg/mL). Additional workup showed seropositivity for anti-parietal cell antibodies and intrinsic factor blocking antibodies, and an esophagogastroduodenoscopy (EGD) biopsy yielded histologic findings consistent with autoimmune gastritis. She was treated acutely with daily intramuscular B12 injections with improvement in hematologic derangements and symptomatology. Arrested erythropoiesis can lead to apoptosis and the high proliferation of immature erythroblasts results in cells that are more susceptible to impaired deoxyribonucleic acid (DNA) synthesis and results in denatured DNA. Pernicious anemia manifesting as DIC has yet to be described in the literature. Here we describe an interesting case of pernicious anemia manifesting as early DIC resulting from arrest of erythropoiesis evidenced by the international society on thrombosis and hemostasis score of 5, diagnostic for DIC. Early recognition and treatment of this reversible etiology of DIC is essential to the improvement of patient outcomes.

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Section: Discussionmentioning

confidence: 99%

“…Cr: creatinine; EGD: esophagogastroduodenoscopy; Hb: hemoglobin; ISTH: Internal Society of Thrombosis and Hemostasis; MCV: mean corpuscular volume; Plt: platelet; pRBCs: packed red blood cells; TTP: thrombotic thrombocytopenic Pernicious Anemia Manifesting as DIC J Med Cases. 2022;13 (11):557-560 purpura…”

Section: Financial Disclosurementioning

confidence: 99%