2019
DOI: 10.1186/s12879-019-3849-y
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Association of active Helicobacter pylori infection and anemia in elderly males

Abstract: Background The prevalence of Helicobacter pylori (H. pylori) infection increases with age. However, the relationship between H. pylori infection and anemia in the elderly population remains to be identified. The aim of this study is to explore whether H. pylori infection is associated with anemia in a male elderly cohort. Methods A cross-sectional study was designed using data collected fro… Show more

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Cited by 31 publications
(33 citation statements)
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References 40 publications
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“…In our study, we did not find any significant correlation between iron deficiency status and risk of folate deficiency and H. pylori infection across the age groups, which was in accordance with the findings of other studies [48,49]. However, some studies have reported association of H. pylori infection with iron deficiency, such that reduced serum ferritin levels were measured in H. pylori infected cases [50][51][52].…”
Section: Discussionsupporting
confidence: 91%
“…In our study, we did not find any significant correlation between iron deficiency status and risk of folate deficiency and H. pylori infection across the age groups, which was in accordance with the findings of other studies [48,49]. However, some studies have reported association of H. pylori infection with iron deficiency, such that reduced serum ferritin levels were measured in H. pylori infected cases [50][51][52].…”
Section: Discussionsupporting
confidence: 91%
“…In general causes of anemia were found to be anemia of chronic disease (ACD) associated with co morbidities, deficiency anemia constituting iron deficiency, vit B 12 deficiency, folate deficiency and others and unexplained anemia. While considering the underlying diseases, anemia in elderly is also seen associated with H. pylori and twice prevalent in people with chronic kidney disease (CKD), withprevalence of anemia increasing with stage of CKD [22,33,41,42]. Under normal circumstances, increased plasma and stored iron levels activate Hepcidin production, a hormone released by liver which in turn inhibits Geriatric Anemia DOI: http://dx.doi.org/10.5772/intechopen.95540 dietary iron absorption.…”
Section: Etiopathogenesismentioning
confidence: 99%
“…The cause of ACD in hospitalized elderly patients is mostly the consequence of added chronic underlying diseases and also is an indicator of several reactive and clonal conditions.3 Many underlying diseases, like H pylori, renal impairment, congestive heart failure, myelodysplastic syndrome (MDS) is seen associated with ACD in elderly [19,42,51]. Although concentrations of serum ferritin, white blood counts (WBC) and C-reactive protein (CRP) levels in ACD patients remains high in ACD but high Hepcidin (H) level occurring due to inflammation facilitates development of ACD in elderly patients.…”
Section: Types Of Anemiamentioning
confidence: 99%
“…Many studies in the last year focused on the correlation between H pylori infection and unexplained anemia. Lopez‐Garcia et al reported that H pylori infection accounts for about 7.8% of iron deficiency anemia (IDA) patients referred to an academic hematology center in northeast Mexico, while Hou et al reported that H pylori seems to be associated with normochromic and normocytic anemia in a Chinese population . Kitila et al looked for H pylori in 195 pregnant and 137 nonpregnant Ethiopian women, reporting that the infection was significantly associated with pregnancy status (RR 1.825; CI 1.42‐2.15; P = .020) and low hemoglobin values (RR 0.177; CI 0.083‐0.379; P = .003), despite the effect of potential confounders, such as socioeconomic status, smoking, alcohol intake, and presence of intestinal parasites .…”
Section: Hematologic Diseasesmentioning
confidence: 99%