Association of Acute Myocardial Infarction with Sudden Sensorineural Hearing Loss: A Population-Based Case-Control Study

Abstract

Objective: Although the etiology of sudden sensorineural hearing loss (SSNHL) remains unknown, there is increasing evidence suggesting an underlying cardiovascular pathomechanism. This study set out to explore a possible association between acute myocardial infarction (AMI) and having previously been diagnosed with SSNHL by using a population-based dataset with a case-control design. Methods: In this study, we utilized administrative claims data from the Taiwan National Health Insurance program to identify 48,674 cases with AMI and to randomly select 243,370 controls. Conditional logistic regression was used to explore the association between AMI and having previously been diagnosed with SSNHL. Results: Of the sampled patients, 1,313 (0.4%) had been diagnosed with SSNHL within 5 years before the index date; 340 (0.75% of the cases) were from the cases and 974 (0.4% of controls) were from the controls. After adjusting for patient geographic region, monthly income, hypertension, diabetes, hyperlipidemia, and coronary heart disease, conditional logistic regression analysis (conditioned on sex, age group, urbanization level, and index date) revealed that the odds ratio for prior SSNHL in patients with AMI was 1.50 (95% CI 1.30–1.70; p < 0.001) that of controls. We found that the adjusted odds ratio of prior hospitalization for the treatment of SSNHL for cases was 2.11 (95% CI 1.65–2.69; p < 0.001) times that of controls. Conclusions: This study identified a novel association between AMI and prior SSNHL. The results of this study highlight a need for clinicians dealing with SSNHL patients to be alert to their risk of subsequent AMI.

Sudden Sensorineural Hearing Loss Associated With Iron-Deficiency Anemia

“…As noted, SSNHL is comorbid with many disorders like cardiovascular and cerebrovascular events. 12,47 Even though all dates of IDA diagnosis in the present study were prior to the SSNHL diagnosis, which rendered an IDA diagnosis irrelevant to various examinations following the SSNHL event, it was still possible that the SSNHL population received laboratory tests more frequently than the control group because of other comorbid diseases. Nonetheless, this potential bias would have little effect on the conclusions.…”

Association of Sudden Sensorineural Hearing Loss With Vertebrobasilar Insufficiency

“…We found that the prevalence of hyperlipidemia, diabetes mellitus, and hypertension was higher among patients with SSNHL, a result consistent with the findings reported in previous studies. [26][27][28]…”

Sudden sensory neural hearing loss is not predictive of myocardial infarction: A longitudinal follow-up study using a national sample cohort

“…In addition to problems in arterial circulation that directly supplies the organ, systemic ischemia, such as that caused by atherosclerosis and hypertension, has been evaluated for an association with SSNHL 4 , 5 . Several previous studies have demonstrated the risk of MI in SSNHL subjects 6 , 7 . A population-based case-control study reported an odds ratio of 1.55 for a history of SSNHL in acute myocardial infarction (AMI) subjects (95% confidence interval [95% CI] = 1.30–1.70, P < 0.001) 7 .…”

“…Several previous studies have demonstrated the risk of MI in SSNHL subjects 6 , 7 . A population-based case-control study reported an odds ratio of 1.55 for a history of SSNHL in acute myocardial infarction (AMI) subjects (95% confidence interval [95% CI] = 1.30–1.70, P < 0.001) 7 . Based on age groups, 50–64- and ≥65-year-old groups with SSNHL demonstrated adjusted hazard ratios (HRs) of 1.62 and 1.28 for MI, respectively (P = 0.0064 and P < 0.001, respectively) 6 .…”