Association of acylation stimulating protein and adiponectin with metabolic risk marker in North Indian obese women

Mishra, Supriya; Gupta, Vishal; Mishra, Sameeksha; Kulshrestha, Himani; Kumar, Sandeep; Gupta, Vandana; Sachan, Rekha; Mahdi, Abbas Ali

doi:10.1016/j.dsx.2018.07.017

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Although baseline C3a was approximately 9% higher in men with abdominal obesity compared with lean men, this difference was not statistically significant. Previous publications have reported higher C3a in people with obesity than in lean individuals, but these reports have often concerned studies in persons with extreme levels of obesity, with obesity-related comorbidities such as metabolic syndrome, and/or with larger numbers of participants (15,(36)(37)(38). This may explain why our current findings that C3a did not change upon a weight-loss intervention in men with abdominal obesity contrasts with a previous report that, in women, plasma C3a was reduced upon extreme weight loss resulting from bariatric surgery (38).…”

Section: Discussionmentioning

confidence: 99%

A randomized diet‐induced weight‐loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction

Jin

Kusters

Houben

et al. 2022

Obesity

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ObjectiveComplement C3 and other components of the alternative pathway are higher in individuals with obesity. Moreover, C3 has been identified as a risk factor for cardiovascular disease. This study investigated whether, and how, a weight‐loss intervention reduced plasma C3, activated C3 (C3a), and factor D and explored potential biological effects of such a reduction.MethodsThe study measured plasma C3, C3a, and factor D by ELISA and measured visceral adipose tissue, subcutaneous adipose tissue, and intrahepatic lipid by magnetic resonance imaging in lean men (n = 25) and men with abdominal obesity (n = 52). The men with obesity were randomized to habitual diet or an 8‐week dietary weight‐loss intervention.ResultsThe intervention significantly reduced C3 (−0.15 g/L [95% CI: −0.23 to −0.07]), but not C3a or factor D. The C3 reduction was mainly explained by reduction in visceral adipose tissue but not subcutaneous adipose tissue or intrahepatic lipid. This reduction in C3 explained a part of the weight‐loss‐induced improvement of markers of endothelial dysfunction, particularly the reduction in soluble endothelial selectin and soluble intercellular adhesion molecule.ConclusionsDiet‐induced weight loss in men with abdominal obesity could be a way to lower plasma C3 and thereby improve endothelial dysfunction. C3 reduction may be part of the mechanism via which diet‐induced weight loss could ameliorate the risk of cardiovascular disease in men with abdominal obesity.

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Section: Discussionmentioning

confidence: 99%

A randomized diet‐induced weight‐loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction

Jin

Kusters

Houben

et al. 2022

Obesity

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“…The impact of ASP and its association with insulin resistance in obese individuals have been extensively researched through various studies. These investigations have assessed parameters such as homeostatic model assessment of insulin resistance (HOMA‐IR), plasma glucose levels and insulin, ultimately establishing a link between ASP and insulin resistance in this population (Castellano‐Castillo et al., 2018; Mishra et al., 2019; Ursini & Abenavoli, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…ASP in circulation increases substantially with overweight and obesity and declines with weight loss. ASP levels are correlated with cardiometabolic risk markers in obese people (Al‐Kuraishy & Al‐Gareeb, 2017; Mishra et al., 2019; Onat et al., 2017). ASP and its component proteins (C3, factor B and adipsin) have been demonstrated to be meaningfully increased in type 2 diabetes as well as in some research on type I diabetes (Cianflone et al., 2003).…”

Section: Introductionmentioning

confidence: 99%

Acylation stimulating protein/C3adesArg in the metabolic states: role of adipocyte dysfunction in obesity complications

Rezvani,

Shadmand Foumani Moghadam,

Cianflone

2024

The Journal of Physiology

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Adipose tissue, as an endocrine organ, secretes several adipocyte‐derived hormones named ‘adipokines’ that are implicated in regulating energy haemostasis. Substantial evidence shows that white adipose tissue‐derived adipokines mediate the link between obesity‐related exogenous factors (like diet and lifestyle) and various biological events (such as pre‐ and postmenopausal status) that have obesity consequences (cardiometabolic disorders). One of the critical aetiological factors for obesity‐related diseases is the dysfunction of adipokine pathways. Acylation‐stimulating protein (ASP) is an adipokine that stimulates triglyceride synthesis and storage in adipose tissue by enhancing glucose and fatty acid uptake. ASP acts via its receptor C5L2. The primary objective of this review is to address the existing gap in the literature regarding ASP by investigating its diverse responses and receptor interactions across multiple determinants of obesity. These determinants include diet composition, metabolic disorders, organ involvement, sex and sex hormone levels. Furthermore, this article explores the broader paradigm shift from solely focusing on adipose tissue mass, which contributes to obesity, to considering the broader implications of adipose tissue function. Additionally, we raise a critical question concerning the clinical relevance of the insights gained from this review, both in terms of potential therapeutic interventions targeting ASP and in the context of preventing obesity‐related conditions, highlighting the potential of the ASP–C5L2 interaction as a pharmacological target. In conclusion, these findings validate that obesity is a low‐grade inflammatory status with multiorgan involvement and sex differences, demonstrating dynamic interactions between immune and metabolic response determinants. image

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“…Different adipocytokines are secreted by adipose tissue, and these hormonal alterations play a key role in metabolic diseases. (9) Leptin and adiponectin are adipocytokines, hormones mainly produced by adipose tissue and responsible for regulating lipid metabolism, insulin resistance and inflammation. (10) While interleukin 6 (IL-6) is a pro-inflammatory cytokine and an anti-inflammatory myokine.…”

Section: Introductionmentioning

confidence: 99%

High Waist to Height ratio (WHtR) Worsens Inflammatory And Adiposity Profiles In Adult Women With Abdominal Obesity

Noer

Rose²,

Fajrani³

et al. 2022

IJND

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ABSTRACTBackground: Women gain weight more easily due to hormonal factors. Abdominal obesity is more at risk for metabolic disease than general obesity. Inflammation in the body is intimately linked to obesity. Adipocytokines are leptin and adiponectin, while IL-6 is a pro-inflammatory cytokine. These three biomarkers are frequently used to describe abdominal obesity individuals.Objective: This study aimed to analyze between Waist-to-Height Ratio (WHtR) with the inflammatory and adiposity profiles in adult women with abdominal obesity.Methods: This study was a cross-sectional research with a total of 88 adult women with abdominal obesity aged 25-45 years who work in the Diponegoro University area of Semarang. Samples were taken by consecutive sampling technique. A serum inflammation profile was measured using the enzyme-linked immunosorbent assay (ELISA) method.Results: The mean waist circumference of the research subjects was 93.82 ± 10.64. The mean WHtR, adiponectin, leptin and IL-6 were 0.61 ± 0.07; 14.15 ± 9.71; 4.64 ± 0.79; 6.49 ± 3.19. The results of the correlation test between WHtR with adiponectin, leptin and IL-6 were (r=-0.279; p=0.005), (r=0.233; p=0.029) and (r=0.271; p=0.011). Compared with anthropometric measurements using BMI, visceral fat, and WC, the WHtR was statistically higher (p<0.05).Conclusion: WHtR was significantly negatively correlated with adiponectin and positively correlated with leptin and IL-6 KEYWORD: Abdominal Obesity; WHtR; Adiponectin; Leptin; Interleukin 6 ABSTRAK Latar Belakang: Wanita lebih mudah mengalami kenaikan berat badan karena faktor hormonal. Obesitas abdominal lebih berisiko terkena penyakit metabolik daripada obesitas umum. Peradangan dalam tubuh berkaitan erat dengan obesitas. Adipositokin merupakan leptin dan adiponektin, sedangkan IL-6 adalah sitokin pro-inflamasi. Ketiga biomarker ini sering digunakan untuk menggambarkan individu dengan obesitas abdominal.Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara Waist-to-Height Ratio (WHtR) dengan profil inflamasi dan adipositas pada wanita dewasa dengan obesitas abdominal.Metode: Penelitian ini merupakan penelitian cross sectional dengan jumlah 88 wanita dewasa dengan obesitas abdominal berusia 25-45 tahun yang bekerja di lingkungan Universitas Diponegoro Semarang. Sampel diambil dengan teknik consecutive sampling. Profil peradangan serum diukur menggunakan metode enzyme-linked immunosorbent assay (ELISA).Hasil: Rerata lingkar pinggang subjek penelitian adalah 93,82 ± 10,64. Rerata WHtR, adiponektin, leptin dan IL-6 adalah 0,61 ± 0,07; 14,15 ± 9,71; 4,64 ± 0,79; 6,49 ± 3,19. Hasil uji korelasi antara WHtR dengan adiponektin, leptin dan IL-6 adalah (r=-0,279; p=0,005), (r=0,233; p=0,029) dan (r=0,271; p=0,011). Dibandingkan dengan pengukuran antropometri menggunakan BMI, lemak visceral, dan WC, WHtR secara statistik lebih tinggi (p<0,05).Kesimpulan: WHtR secara signifikan berkorelasi negatif dengan adiponektin dan berkorelasi positif dengan leptin dan IL-6 KATA KUNCI: Obesitas Abdominal; WHtR; Adiponektin; Leptin; Interleukin 6

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Association of acylation stimulating protein and adiponectin with metabolic risk marker in North Indian obese women

Cited by 6 publications

References 27 publications

A randomized diet‐induced weight‐loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction

A randomized diet‐induced weight‐loss intervention reduces plasma complement C3: Possible implication for endothelial dysfunction

Acylation stimulating protein/C3adesArg in the metabolic states: role of adipocyte dysfunction in obesity complications

High Waist to Height ratio (WHtR) Worsens Inflammatory And Adiposity Profiles In Adult Women With Abdominal Obesity

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