Association of Adenoid Surface Biofilm Formation and Chronic Otitis Media With Effusion

Saylam, Güleser; Tatar, Emel Çadallı; Tatar, İlkan; Özdek, Ali; Korkmaz, Hakan

doi:10.1001/archoto.2010.70

Cited by 56 publications

(52 citation statements)

References 23 publications

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“…There is no univerTurkiye Klinikleri J Med Sci 2013;33 (6) sally accepted grading system, but we used a grading system which was used in the previous studies of one of our authors. [7][8][9] Analysis of the data was done using SPSS (SPSS for Windows, version 11.5, SPSS, Chicago, IL). Continuous variables were expressed as mean ± standard deviation (SD) and categorical variables were expressed as percentages.…”

Section: Methodsmentioning

confidence: 99%

Presence of Biofilms in the Lacrimal Sac Mucosa

Koşarsoy¹,

Özer²,

Öǧretmenoǧlu³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The inflammation and the following fibrosis due to the bacterial colonization are thought to be the principle underlying mechanism in the development of nasolacrimal duct stenosis. The aim of this study was to investigate the presence of biofilms in the lacrimal sac mucosa of the patients with dacryostenosis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included 15 patients with a symptom of epiphora for at least 3 months and documented dacryostenosis with a dacryocystography. Lacrimal sac mucosal specimens obtained during endoscopic dacryocystorhinostomy (DCR) were examined for the presence of biofilm formation under the scanning electron microscope. R Re es su ul lt ts s: : The specimens were obtained from 15 patients. The mean age of 12 female and 3 male patients was 54 years. Epiphora was the main symptom and its average duration was 18 (6-36) months. We could not analyze specimen in 1 patient. We detected biofilm formation in 12 of 14 (% 85.7) specimens. Biofilm formation was dense in 5 specimens and light in 7 specimens. C Co on nc cl lu us si io on n: : This is the first article that documents the presence of bacterial biofilms on the lacrimal sac mucosa in the patients with dacryostenosis. This study shows the presence of biofilms in cases with dacryostenosis and interrogates its role in the etiology of chronic dacryocystitis similar to other chronic infections. Further investigations on this subject should be carried on in larger and controlled series to assure the role of biofilms in the etiology of chronic infections. New studies should also investigate whether the biofilm formation is the reason or the result of chronic infections. We believe that, control of biofilm formation in chronic infections would prevent secondary problems like the development of dacryostenosis.K Ke ey y W Wo or rd ds s: : Biofilms; dacryocystitis; microscopy, electron, scanning; dacryocystorhinostomy Ö ÖZ ZE ET T A Am ma aç ç: : Bakteriyel kolonizasyon sonucu gelişen inflamasyon ve fibrozis, nazolakrimal kanal stenozuna yol açan temel mekanizma olarak kabul edilmektedir. Bu çalışmanın amacı, dakriostenozlu olguların lakrimal kese mukozalarında biofilm varlığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmaya en az 3 aydır epifora şikayeti olan ve dakriosistografide dakriostenoz tespit edilen 15 olgu dahil edilmiştir. Endoskopik dakriosistorinostomi sırasında elde edilen lakrimal kese mukoza örnekleri, tarayıcı elektron mikroskopide incelenerek biyofilm varlığı araştırılmıştır. B Bu ul lg gu ul la ar r: : Ortalama yaşı 54 olan 12 kadın ve 3 erkek, toplam 15 hasta çalışmaya dahil edilmiştir. Hastalarda görülen en sık semptom epifora idi ve ortalama 18 aydır mevcuttu. İncelenen 14 spesmenin 12 (%85,7)'sinde biyofilm tespit edildi. Spesmenlerin 1 tanesinin analizi yapılamadı. Biyofilm formasyonu örneklerin 5'inde hafif, 7'sinde ise yoğun idi. S So on nu uç ç: : Bu makale dakriostenozlu hastaların lakrimal kese muko...

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Section: Methodsmentioning

confidence: 99%

Presence of Biofilms in the Lacrimal Sac Mucosa

Koşarsoy¹,

Özer²,

Öǧretmenoǧlu³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…It has been shown that 75.4% of children affected by obstructive adenoid hypertrophy (grade 3-4) also presented with chronic rhinitis [31]. Saylam et al [32] pointed out the role of chronic infection of the nose and nasopharynx. Otitis media with effusion has been recently proposed, and adenoid bacterial biofilms seem to play a particularly fundamental role.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

An objective assessment of halitosis in children with adenoid vegetation during pre- and post-operative period

Dinç

Altundağ

Dizdar

et al. 2016

International Journal of Pediatric Otorhinolaryngology

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“…Otitis media with effusion (OME) is a multifactorial disease with infection, possibly biofilm in nature (3,4) and Eustachian tube dysfunction (5) are the most widely accepted etiologies. Many risk factors have been associated with this disease: young age (6,7) lack of breast feeding (6,8,9) low mother education, (9)(10)(11) low socioeconomic status (6,10) day care attendance (8,11) parental smoking, (6,11,12) upper respiratory tract infections (6,9,11) allergy (6,9,11,13,14) and snoring.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Otitis Media with Effusion in School Children in Qassim Region of Saudi Arabia

Alhumaid¹,

Abou-Halawa²

2014

IJHS

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Abstract:Objective: To determine the prevalence of otitis media with effusion (OME) among school children in Qassim region of Kingdom of Saudi Arabia and to determine relevant risk factors in affected children. Methods:Through a cross-sectional study, 1488 children in the age range 6-12 years were randomly selected from 25 primary schools in Qassim region. A questionnaire was used to determine risk factors for OME. Otoscopy and tympanometry were used to diagnose and confirm OME. Pure tone average for children with confirmed OME was measured. Teachers of children were asked to complete a questionnaire evaluating child's level of school performance. Results:Prevalence of OME in the study population was 7.5% (112/1488). In univariate analysis, it was strongly associated with age less than 8 years (p< 0.0001; OR= 4.23, 95% CI: 2.85-6.29 ), family size more than 4 members in the household((p<0.0001; OR= 4.45, 95% CI: 2.23-8.88), mother education less than secondary school education (p<0.0001; OR=2.2, 95% CI: 1.47-3.29), recurrent acute otitis media (AOM) (p<0.0001; OR=5.73, 95% CI: 3.47-9.45), and hearing loss symptom (p< 0.0001; OR= 3.39, 95% CI: 1.92-5.99). It is less strongly associated with history of preschool AOM (p= 0.002; OR= 3.15, 95% CI: 1.67-5.97), nasal discharge (p= 0.003; OR= 1.91, 95% CI: 1.24-2.93) and snoring (p=0.03; OR= 1.76, 95% CI: 1.06-2.94). OME was significantly higher in schools located in rural districts (p<0.001, OR= 2.82, 95% CI: 1.86 -4.28). In multivariate regression model, five of these factors were found to be predictors of OME: age less than 8 years (OR= 5.052, 95% CI:3.289-7.762), family size more than4 members in the household) (OR= 4.192, 95% CI: 2.033-8.643), rural school district (OR=3.037, 95% CI: 1.933-4.772), mother education lower than secondary school education) (OR=2.041, 95% CI:1.602-3.877) and recurrent AOM (OR=4.914, 95% CI: 2.677-9.02). Children with OME tend to have poorer school performance compared to normal children (p=0.067). No significant correlation was found between OME and type of feeding during the first two years of life (p=0.62; OR= 0.87, 95% CI: 0.51-1.49), preschool daycare attendance (p=0.17; OR= 0.71, 95% CI: 0.44-1.16), home exposure to cigarette smoke (p=0.4; OR= 1.34, 95% CI:0.68 -2.65), visits to ENT clinic (p=0.13; OR= 0.58, 95% CI:0.29-1.18), and ENT operations (p=0.12; OR= 0.46, 95% CI: 0.17-1.27). Conclusion:Prevalence of OME in Qassim region reaches 7.5% in school children. Age less than 8 years, family size more than 4 members in the household, mother education less than secondary school education, living in rural area and recurrent AOM are found to be predictors of OME in Qassim region. In this population of children, otoscopy and tympanometry should be used as screening tools for OME.

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Association of Adenoid Surface Biofilm Formation and Chronic Otitis Media With Effusion

Abstract: In pediatric patients, adenoid surface biofilm formation may be associated with COME etiopathogenesis.

Cited by 56 publications

References 23 publications

Presence of Biofilms in the Lacrimal Sac Mucosa

Presence of Biofilms in the Lacrimal Sac Mucosa

An objective assessment of halitosis in children with adenoid vegetation during pre- and post-operative period

Prevalence and Risk Factors of Otitis Media with Effusion in School Children in Qassim Region of Saudi Arabia

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