Association of Adenovirus Type 8 with Epidemic Keratoconjunctivitis

Mitsui, Yuta

doi:10.1001/archopht.1959.00940090893004

Cited by 39 publications

(9 citation statements)

References 10 publications

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“…The isolation rate obtained in specimens collected during the first week of infection was 3-5 times higher than the rate obtained in specimens collected after the first week. This finding confirms previous reports (Mitsui et al, 1957(Mitsui et al, , 1959Ellison et al, 1969;Dawson et al, 1970) that early collection of specimens from patients with adenovirus infection is an important factor in obtaining satisfactory results from cultural tests.…”

Section: Discussionsupporting

confidence: 92%

Comparative sensitivity of a cultural test and the complement fixation test in the diagnosis of adenovirus ocular infection.

Gibson¹,

Darougar²,

McSwiggan³

et al. 1979

British Journal of Ophthalmology

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SUMMARY The sensitivity of human embryonic kidney (HEK) cell culture and the complement fixation test (CFT) The ocular morbidity associated with adenovirus infections varies considerably. These eye infections constitute a major economic problem owing to the loss of a considerable number of working days each year. Sporadic cases of acute follicular conjunctivitis and keratoconjunctivitis caused by various serotypes of adenovirus are common entities. Adenovirus serotypes 3, 4, 7, 8, and 19 particularly are responsible for outbreaks of the disease in hospitals, factories, and schools (Editorial, 1977).Several laboratory tests are available for the diagnosis of adenovirus ocular infection. Cell cultures for virus isolation and the complement fixation test (CFT) for detection of antibody to adenovirus group antigen are routine laboratory procedures which are extensively used for the diagnosis of ocular infection.In this paper we compare the sensitivity of a primary human embryonic kidney (HEK) cell culture system with the complement fixation test for the diagnosis of adenovirus infection of the eye. The optimum time for collection of specimens Correspondence to Dr S. Darougar, Institute of Ophthalmology, Judd Street, London WCIH 9QS, to obtain the highest positivity rate by each test is discussed. Materials and methods SELECTION OF PATIENTSPatients attending the clinic with moderate to severe follicular conjunctivitis or keratoconjunctivitis clinically suggestive of an adenovirus infection were included in this study. CULTURAL TESTSwabbings collected from different areas of the conjunctiva (Darougar and Jones, 1971) were placed in plastic capsules containing 2SP transport medium (Gordon et al., 1969) with additional fetal bovine serum, and stored at -70°C until required.Each specimen was inoculated into 2 tubes of HEK cells and examined at regular intervals for the presence of cytopathic effect (CPE) for up to 21 days (McSwiggan et al., 1975). The isolates were identified and serotyped by standard methods. SEROLOGICAL TESTSerum collected by venepuncture was tested by a complement fixation test (Bradstreet and Taylor,

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Section: Discussionsupporting

confidence: 92%

Comparative sensitivity of a cultural test and the complement fixation test in the diagnosis of adenovirus ocular infection.

Gibson¹,

Darougar²,

McSwiggan³

et al. 1979

British Journal of Ophthalmology

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“…The severity of EKC ranges from subclinical conjunctivitis to severe diseases with bacterial superinfection. Lid swelling and associated inflammatory ptosis are usually seen only in the primarily affected eye [14, 15]. …”

Section: Discussionmentioning

confidence: 99%

Orbital Inflammation Developing from Epidemic Keratoconjunctivitis in an Adult

Kim

Lee

2013

Case Rep Ophthalmol

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Introduction: We report a rare case of epidemic keratoconjunctivitis (EKC) that developed into an orbital inflammation in an adult. Case Presentation: A 67-year-old Korean man, who had been diagnosed with EKC and treated for conjunctival injection and chemosis in the right eye for 4 days, was referred to Oculoplastics as orbital cellulitis was suspected. At the point of referral, clinical features such as decreased visual acuity, severe eyelid swelling, chemosis, follicles, corneal edema, limitations in lateral eye movement, and diplopia were observed in the right eye. Orbital cellulitis was suspected according to orbital computed tomography scan images, but there was no response to systemic antibiotics. Systemic steroid was administered instead, and then his symptoms and signs started to improve. The final diagnosis of this patient was orbital inflammation related to EKC based on the facts that there was no response to antibiotics, that he presented with contralateral symptoms and signs, that pseudomembrane formation occurred in both eyes, and that the symptoms resolved completely after 2 weeks. Conclusion: Clinicians need to consider the possibility of orbital inflammation developing from EKC, even in an adult patient, and treat the patient properly if the EKC symptoms and signs, such as conjunctival injection and follicles, are accompanied with symptoms and signs similar to orbital cellulitis.

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“…The incubation period of these viruses is typically from 5 to 12 days, with a range of from 1 to 30 days. Epidemic potential is, in part, the result of the following virus characteristics: (1) shedding from the eye beginning up to 3 days before and continuing up to 14 days after symptom onset; (2) failure of standard disinfectants such as ammonia to inactivate these viruses; and (3) viruses deposited on environmental surfaces remaining infectious for up to a week 4,5 …”

Section: Introductionmentioning

confidence: 99%

Epidemic Keratoconjunctivitis in a Chronic Care Facility: Risk Factors and Measures for Control

Buffington

Chapman

Stobierski

et al. 1993

J American Geriatrics Society

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Transmission of infection with adenovirus type 37 was successfully interrupted following strict infection control, suspension of new admissions, cohorting of residents by unit, and change to a disinfectant that inactivates adenovirus. Recognition of conjunctivitis as an appropriate reason for restricting movement of an infected resident may have prevented extensive viral transmission in this outbreak.

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Association of Adenovirus Type 8 with Epidemic Keratoconjunctivitis

Cited by 39 publications

References 10 publications

Comparative sensitivity of a cultural test and the complement fixation test in the diagnosis of adenovirus ocular infection.

Comparative sensitivity of a cultural test and the complement fixation test in the diagnosis of adenovirus ocular infection.

Orbital Inflammation Developing from Epidemic Keratoconjunctivitis in an Adult

Epidemic Keratoconjunctivitis in a Chronic Care Facility: Risk Factors and Measures for Control

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