Association of ADH1C and ALDH2 genes with alcohol dependence in south Indian Tamilian population

Arunachalam, Umamageswari; Manoharan, Aarthi; Kannan, I; Adithan, C

doi:10.53730/ijhs.v6ns3.8247

Cited by 1 publication

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our result was similar to previously studies (Yokoyama et al, 2013;Edenberg and McClintick, 2018;Wang et al, 2020). However, this result isn't inconsistent, the ALDH2*2 allele frequency was significantly lower in alcoholics of Korean, Japanese, Taiwan, Han -China and Vietnamese this study comparing healthy non-alcoholics group (Chen et al, 1999;Feng et al, 2008;Yokoyama et al, 2013;Jiang et al, 2017) except Indians and Hakka -China (Rao et al, 2017;Arunachalam et al, 2022;Chen et al, 2022). This allele could play a protective role against alcoholism in Korean, Japanese, Taiwanese, Han -China and Vietnamese but be a risk factor for alcoholism in Indians and Hakka -China.…”

Section: Discussionsupporting

confidence: 90%

Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam

Hoang

Nguyen

et al. 2023

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Objective: Alcohol abuse can cause developing cirrhosis, even liver cancer. Several single nucleotide polymorphisms (SNPs) of ADH1B , ADH1C , and ALDH2 genes have been reported to be associated with alcohol abuse and alcoholic cirrhosis (ALC). This study investigated the association between three SNPs of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with alcohol abuse and ALC in people living in the Northeast region of Vietnam. Methods: 306 male participants were recruited including 206 alcoholics (106 ALC, 100 without ALC) and 100 healthy non-alcoholics. Clinical characteristics were collected by clinicians. Genotypes were identified by Sanger sequencing. Chi-Square (χ2) and Fisher-exact tests were used to assess the differences in age and clinical characteristics, Child-Pugh score, frequencies of alleles and genotypes. Result: Our data showed that the frequency of ALDH2 *1 was significantly higher in alcoholics (88.59%) and ALC groups (93.40%) than that of healthy non-alcoholics (78.50%) with p=0.0009 and non-ALC group (83.50%) with p=0.002, respectively. We detected opposite results when examined ALDH2 *2. Frequency of combined genotypes with high acetaldehyde accumulation were significantly lower in alcoholics and ALC group than those of control groups with p=0.005 and p=0.008, respectively. Meanwhile, the proportion of combined genotypes with non-acetaldehyde accumulation were significantly two times higher in the ALC group (19.98%) than those of the non-ALC group (8%) with p=0.035. These combined genotypes showed a decreasing trend in the Child-Pugh score from likely phenotype causing risk for non-acetaldehyde accumulation to high acetaldehyde accumulation. Conclusion: The ALDH2 *1 allele was found as a risk factor for alcohol abuse and ALC, and combined genotypes of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with non-acetaldehyde accumulation increase ALC risk. In contrast, ALDH2 *2 and the genotype combinations related to high acetaldehyde accumulation were protective factors against alcohol abuse and ALC.

show abstract