Association of Adiponectin Gene Functional Polymorphisms (+45T/G and 276G/T) with Obese Breast Cancer

N, Mohan Reddy

doi:10.4172/2155-9929.1000138

Cited by 4 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with our results, Reddy et al . demonstrated that the presence of the TG genotype at the position +45 of the ADIPOQ gene may be associated with the risk of BC in obese Indian women.…”

Section: Discussionsupporting

confidence: 93%

Genetic and epigenetic modifications of adiponectin gene: Potential association with breast cancer risk

Pasha

Mohamed

Toam

et al. 2019

The Journal of Gene Medicine

View full text Add to dashboard Cite

Background: Adipokines produced by adipose tissue are directly linked to obesity and may contribute to the pathogenesis of cancer. We hypothesized that genetic and epigenetic modifications in the adiponectin (ADIPOQ) gene and their impact on serum ADIPOQ levels may participate in increasing breast cancer (BC) risk. The present study aimed to investigate ADIPOQ +45 T/G gene polymorphism, methylation status at CpG sites −74 nucleotides (nt) and −283 nt of the ADIPOQ gene, and ADIPOQ serum levels in BC obese women.Methods: Serum ADIPOQ was measured by an enzyme-linked immunosorbent assay. ADIPOQ +45 T/G gene polymorphism and ADIPOQ promoter methylation status were determined using a polymerase chain reaction (PCR) and a methylationspecific PCR, respectively, in 120 obese women with BC and 120 age-matched controls.Results: ADIPOQ +45 GG genotype carriers had a significant increased risk of developing BC (odds ratio = 6.2, 95% confidence interval = 1.3-29.6, p = 0.02).ADIPOQ gene methylation at site −74 nt resulted in a 1.7-fold increased BC risk.Methylation at site -283 nt resulted in a 1.9-fold increased BC risk. Moreover serum levels of ADIPOQ were significantly decreased in BC patients and down-regulated in the presence of methylation in both examined sites. By contrast, no association between ADIPOQ gene polymorphism and serum ADIPOQ level was detected. Using both methylated sites in one panel detected cancer breast with 76.67% sensitivity and 62.18% accuracy.Conclusions: ADIPOQ +45 T/G polymorphism and ADIPOQ promoter methylation were found to be associated with BC risk in obese Egyptian women.

show abstract

Section: Discussionsupporting

confidence: 93%

Genetic and epigenetic modifications of adiponectin gene: Potential association with breast cancer risk

Pasha

Mohamed

Toam

et al. 2019

The Journal of Gene Medicine

View full text Add to dashboard Cite

show abstract

“…In our study, there was a significant relationship between breast cancer and risk alleles of AdipoT45G and Adi-poG276T polymorphisms. Similar results were reported by Reddy in an Indian population (32), whereas Nyante et al found no significant relationship with breast cancer (33).…”

Section: Discussionsupporting

confidence: 82%

The Effects of BMI and Genetic Variation of Adipokines on Serum Concentrations of Hormones in Untreated Individuals with Breast Cancer; a Pilot Study

Fard

2022

Int J Cancer Manag

View full text Add to dashboard Cite

Background: Numerous studies have shown an association between hormones secreted by adipose tissues and cancer development. Objectives: This study aimed at investigating the effect of body mass index (BMI) and genetic variation of leptin and adiponectin on serum concentrations of leptin, adiponectin, and estradiol among untreated breast cancer. Methods: This case-control study was performed on 350 women (175 women with breast cancer and 175 healthy controls), who had not taken any medications. Serum levels of estradiol (17-beta estradiol), leptin, and adiponectin were measured, using the ELISA technique. Single-nucleotide polymorphisms of leptin gene (LepG2548A), leptin receptor (Q223, K109R, and K656N), and adiponectin gene (T45G, G276T, C11377G, and 11391A) in blood-isolated DNA were evaluated, using RFLP-PCR technique. Results: Body mass index can affect serum concentrations of hormones and is associated with breast cancer. Also, except for adiponectin C11377G polymorphism, other all genetic variations showed significant relationships with breast cancer. In both groups, BMI was significantly correlated with the mean serum concentrations of hormones, and the risk of breast cancer increased in G2548A, Q223R, K656N, and G276T polymorphisms. The effect of risk allele genotypes on serum concentration of hormones showed that changes in serum concentration of estrogen and leptin in all studied polymorphisms were associated with breast cancer in postmenopausal women. But adiponectin level was only affected by polymorphisms K109R, K656N, and G276 and G11391A. Conclusions: High BMI and genetic variation can affect cancer development by changing the serum concentrations of hormones in different genotypes. Studying various populations’ genetics and lifestyle can help definitive conclusions about genetics and obesity.

show abstract

“…Adiponectin 45T/G and 276T/G gene polymorphisms are of gene polymorphisms associated with breast cancer (8,27,28). In a study by Al Khaldi et al (27), the adiponectin gene 45T>G was found more frequently in patients with breast cancer in Kuwait, and the adiponectin gene was considered to predispose for breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Adiponectin and Breast Cancer

et al. 2016

View full text Add to dashboard Cite

Association of Adiponectin Gene Functional Polymorphisms (+45T/G and 276G/T) with Obese Breast Cancer

Cited by 4 publications

References 19 publications

Genetic and epigenetic modifications of adiponectin gene: Potential association with breast cancer risk

Genetic and epigenetic modifications of adiponectin gene: Potential association with breast cancer risk

The Effects of BMI and Genetic Variation of Adipokines on Serum Concentrations of Hormones in Untreated Individuals with Breast Cancer; a Pilot Study

The Relationship between Adiponectin and Breast Cancer

Contact Info

Product

Resources

About