Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study

Hegener, Hillary H.; Lee, I-Min; Cook, Nancy R.; Ridker, Paul M.; Zee, Robert Y.L.

doi:10.1373/clinchem.2006.074476

Cited by 56 publications

(43 citation statements)

References 31 publications

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“…A prospective study focused on the determination of SNPs participation in the development of IR in French population found that variations in the adiponectin gene affects weight gain, body fat distribution and the development and the onset of hyperglycemia, as well as serum adiponectin [24]. At the start of a three-year study, the normoglycemic individuals with no signs of diabetes or impaired glucose tolerance were influenced mainly by two SNPs: G-11391A and T+45G.…”

Section: Adiponectin and Gene Polymorphismsmentioning

confidence: 99%

“…An interesting work was published in 2006 in Clinical Chemistry by Hegener et al [24]; the prospective study monitoring the risk of atherothrombotic disease in individuals with no signs of diabetes. Five SNPs in the gene for adiponectin were investigated in 600 Caucasian men with subsequent aterotrombotic events (myocardial infarction or stroke) and 600 controls.…”

Section: Adiponectin and Gene Polymorphismsmentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Novotny¹,

Vaverková²,

Karásek³

2012

Lipoproteins - Role in Health and Diseases

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Section: Adiponectin and Gene Polymorphismsmentioning

confidence: 99%

Section: Adiponectin and Gene Polymorphismsmentioning

confidence: 99%

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Novotny¹,

Vaverková²,

Karásek³

2012

Lipoproteins - Role in Health and Diseases

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“…[21][22][23][24][25][26] SNPs in other genes from these pathways modulate CHD risk, presumably through their effects on lipids. [27][28][29][30][31] Thus, inclusion of these genes among enriched gene sets is supported by existing scientific literature.…”

Section: Discussionmentioning

confidence: 91%

Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets

Fuentes¹,

Yang

Dávila‐Román³

et al. 2012

Eur J Hum Genet

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Genome-wide association (GWA) studies of complex diseases including coronary heart disease (CHD) challenge investigators attempting to identify relevant genetic variants among hundreds of thousands of markers being tested. A selection strategy based purely on statistical significance will result in many false negative findings after adjustment for multiple testing. Thus, an integrated analysis using information from the learned genetic pathways, molecular functions, and biological processes is desirable. In this study, we applied a customized method, variable set enrichment analysis (VSEA), to the Framingham Heart Study data (404 467 variants, n ¼ 6421) to evaluate enrichment of genetic association in 1395 gene sets for their contribution to CHD. We identified 25 gene sets with nominal Po0.01; at least four sets are previously known for their roles in CHD: vascular genesis (GO:0001570), fatty-acid biosynthetic process (GO:0006633), fatty-acid metabolic process (GO:0006631), and glycerolipid metabolic process (GO:0046486). Although the four gene sets include 170 genes, only three of the genes contain a variant ranked among the top 100 in single-variant association tests of the 404 467 variants tested. Significant enrichment for novel gene sets less known for their importance to CHD were also identified: Rac 1 cell-motility signaling pathway (h_rac1 Pathway, Po0.001) and sulfur amino-acid metabolic process (GO:0000096, Po0.001). In summary, we showed that the pathway-based VSEA can help prioritize association signals in GWA studies by identifying biologically plausible targets for downstream searches of genetic variants associated with CHD.

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“…An important role in this system plays adiponectin [5]. Adiponectin is an adipose tissuespecific plasma protein produced in growing adipocytes, prevents the formation of IR syndrome, increases the sensitivity of hepatocytes and muscle to insulin, possesses a protective effect on the vascular wall, modulates insulin sensitivity, energy homeostasis, glucose and lipid metabolism, and anti-inflammatory responses in the vascular system [11,12]. However, as soon as fat tissue increases in volume, adiponectin concentration is reduced [13], and the low level of this hormone is combined with the further development of obesity-related disturbances [14].…”

Section: Introductionmentioning

confidence: 99%

Однонуклеотидні Поліморфізми Гена Адипонектину У Хворих На Цукровий Діабет 2-Го Типу Та Неалкогольну Жирову Хворобу Печінки

Karachentsev¹,

Gorshunska²,

Tyzhnenko³

et al. 2021

Mìžnarodnij endokrinologìčnij žurnal

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Abstract. Background. It is generally believed that environmental and genetic factors interact with the formation of nonalcoholic fatty liver disease (NAFLD) phenotype and determine its progression. Both NAFLD and type 2 diabetes (T2D) are heterogeneous diseases with common pathogenic pathways. Adiponectin is an adipokine, which increases the sensitivity of hepatocytes and muscle to insulin NAFLD (190.18 ± 22.15 vs 133.32 ± 13.58 mmol/L·pmol/L, p < 0.02), with negative correlation between Adipo-IR and adiponectin level in T2D patients with NAFLD only (r s = -0.350, p = 0.021). Stratification of non-NAFLD patients by +276G/T genotype suggests the prevalence of GT-and TT-genotypes. Thus, the rs1501299 G-allele increased the risk of NAFLD in comparison with p < 0.05). We also found a significant difference in the frequency of -11391G/A between T2D and control groups, but not between the patients with and without NAFLD. We observed that the haplotype of GT/GG had been more common in T2D with NAFLD, and twice less often detected in patients without hepatic disease (33 and 16.49 %, respectively, p < 0.05). (rs1501299 G-allele, rs17300539 and rs1501299 GG/GG and GT/GG haplotypes, respectively) Conclusions. We can recommend Adipo-IR index as a predictive marker for the NAFLD development and the indicator for therapy success in T2D patients. We established new genetic markers

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Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study

Cited by 56 publications

References 31 publications

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets

Однонуклеотидні Поліморфізми Гена Адипонектину У Хворих На Цукровий Діабет 2-Го Типу Та Неалкогольну Жирову Хворобу Печінки

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