Association of Adiponectin Polymorphism with Metabolic Syndrome Risk and Adiponectin Level with Stroke Risk: A Meta-Analysis

Abstract

Many previous studies have provided evidence that the ADIPOQ +45T>G polymorphism (rs2241766) might cause metabolic syndrome (MS). As a cardiovascular manifestation of MS, the incidence of stroke is associated with adiponectin; however, the results remain controversial and inconsistent. Systematic searches of relevant studies published up to Dec 2014 and Jan 2016 on the ADIPOQ +45T>G polymorphism and the risk of MS and adiponectin levels and the risk of stroke, respectively, were conducted in MEDLINE and EMBASE. The odds ratio (OR) or risk ratio (RR) and their 95% confidence interval (95% CI) were extracted. Sixteen studies containing 4,113 MS cases and 3,637 healthy controls indicated a weak positive association between ADIPOQ +45 T>G and MS in the dominant genetic model (OR = 1.30, 95% CI = 1.03–1.65), which was also validated by stratified subgroup analyses. Twelve studies including 26,213 participants and 4,246 stroke cases indicated that 5 μg/ml increments in adiponectin level were not relevant to stroke risk (RR = 1.05, 95% CI = 1.00–1.10, P = 0.069). This study suggested a weak positive association of ADIPOQ +45T>G with MS and a strong association with metabolic-related disease. Additionally, adiponectin level was not a causal factor of increasing stroke risk.

The association between serum adiponectin and 3-month outcome after ischemic stroke

“…Lastly, the cross-sectional study could not confirm any causal relationship. One study suggested that adiponectin level was not a causal factor of increasing stroke risk [65].…”

Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome

“…Prior studies found that modulation of ADPQ level and the susceptibility of insulin resistance might share a common genetic basis located in the human 3q27 locus (Vasseur et al, 2003 ; Yang and Chuang, 2006 ). Accordingly, key variations of the APM1 gene that encodes ADPQ protein were associated with MetS prevalence (Gao et al, 2013 ; Yuan et al, 2016 ). However, the causative role of ADPQ levels as an overall phenotype based on a gene-environmental interaction upon MetS occurrence has not been systematically reviewed to date.…”

β2-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

“…The quality of the identified studies was assessed according to a “methodological quality assessment scale,” which was modified from the study by Yuan et al (2016). Five items, including the representativeness of the cases, the source of controls, sample size, quality control of the genotyping methods, and HWE, were evaluated on this scale.…”