Association of adipose most abundant transcript 1 gene (<i>apM1</i>) with type 2 diabetes mellitus in a Chinese population: a meta‐analysis of case‐control studies

Li, Shengbing; Li, Ling; Li, Ké; Qi, Xiaojuan; Hoekema, Dale; Liu, Hua; Yang, Gangyi

doi:10.1111/j.1365-2265.2007.03114.x

Cited by 14 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six meta-analysis of the association between the genetic variants in the ADIPOQ gene and T2DM have been published [74], [80]–[84]. Menzaghi et al [74] found no association between any of the SNPs (rs2241766/rs1501299/rs266729) and T2DM among populations from all over the world.…”

Section: Discussionmentioning

confidence: 99%

Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population

et al. 2013

View full text Add to dashboard Cite

BackgroundThe prevalence of metabolic syndrome has been rising worldwide, including in China, but knowledge on specific genetic determinants of metabolic syndrome is very limited. A number of studies have reported that polymorphisms in the ADIPOQ gene are associated with metabolic syndrome in Chinese Han populations. However, data is still conflicting. The objective of this study was to examine the associations of the adiponectin genetic variants with metabolic syndrome by a case-control study and meta-analyses in Chinese.MethodsWe first investigated the association of ADIPOQ rs2241766 (+45T>G in exon 2), rs266729 (−11377C>G in promoter) and rs1501299 (+276G>T in intron 2) polymorphisms with metabolic syndrome in a Hubei Han Chinese population with 322 metabolic syndrome patients and 161 normal controls recruited from the Yichang, Hubei. Then we comprehensively reviewed the association between ADIPOQ rs2241766/rs266729/rs1501299 and metabolic syndrome in the Chinese populations via a meta-analysis. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CI).ResultsThe G allele frequency of rs2241766 in metabolic syndrome patients was significantly higher than those of controls group (29.8% vs 23.3%, OR = 1.40, P = 0.033). The logistic regression analysis adjusted by gender and age showed a nominally significant association for rs2241766 GG+GT genotype (P = 0.065, OR = 1.55) and rs1501299 GG genotype in recessive model (OR = 1.54, P = 0.066). However, no association was observed for rs266729 in our sample. We identified thirteen studies for rs2241766 (2,684 metabolic syndrome patients and 2,864 controls), three studies for rs266729, and eleven studies for rs1501299 (2,889 metabolic syndrome patients and 3,304 controls) in Chinese. Meta-analysis indicated significant associations for the rs2241766 G allele (OR = 1.14, 95%CI = 1.05–1.24, P = 0.003), rs266729 GG+GT genotypes (OR = 0.80, 95%CI = 0.68–0.92, P = 0.003) and rs1501299 GG+TG genotypes (OR = 1.42, 95%CI 1.16–1.75, P = 0.001).ConclusionsOur results demonstrated ADIPOQ as a pleiotropic locus for metabolic syndrome and its components in the Han Chinese population.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population

et al. 2013

View full text Add to dashboard Cite

show abstract

“…It is noteworthy that +45T>G (rs2241766) and +276G>T (rs1501299) were closely associated with susceptibility to type 2 diabetes in a Japanese population [25], but not in French or Swedish whites [37,38], while 45TG+GG and 276GG were associated with increased risk of type 2 diabetes in Chinese populations [69]. However, our meta-analysis did not find significant associations between the SNPs +45T>G (rs2241766) and +276G>T (rs1501299) and type 2 diabetes in Asians and whites.…”

Section: Discussionmentioning

confidence: 99%

Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, −11377C>G, −11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis

Han

Jiao

et al. 2011

Diabetologia

View full text Add to dashboard Cite

Aims/hypothesis The associations between adiponectin polymorphisms and type 2 diabetes have been studied widely; however, results are inconsistent. Methods We searched electronic literature databases and reference lists of relevant articles. A fixed or random effects model was used on the basis of heterogeneity. Sub-group and meta-regression analyses were conducted to explore the sources of heterogeneity.

show abstract

“…The previous meta-analysis included eight papers for SNP+45 and four papers for SNP+276[48], whereas we combined our results with those of recently published studies, namely 23 papers for SNP+45 and 11 papers for SNP+276. As a result, we were able to conduct a comprehensive meta-analysis in which the number of studies was almost three times higher than in the previous analysis[48].…”

Section: Discussionmentioning

confidence: 99%

Association of Adiponectin SNP+45 and SNP+276 with Type 2 Diabetes in Han Chinese Populations: A Meta-Analysis of 26 Case-Control Studies

Shi

et al. 2011

PLoS ONE

View full text Add to dashboard Cite

Recently, many studies have reported that the SNP+45(T>G) and SNP+276(G>T) polymorphisms in the adiponectin gene are associated with type 2 diabetes (T2DM) in the Chinese Han population. However, the previous studies yielded many conflicting results. Thus, a meta-analysis of the association of the adiponectin gene with T2DM in the Chinese Han population is required. In the current study, we first determined the distribution of the adiponectin SNP+276 polymorphism in T2DM and nondiabetes (NDM) control groups. Our results suggested that the genotype and allele frequencies for SNP+276 did not differ significantly between the T2DM and NDM groups. Then, a meta-analysis of 23 case-control studies of SNP+45, with a total of 4161 T2DM patients and 3709 controls, and 11 case-control studies of SNP+276, with 2533 T2DM patients and 2212 controls, was performed. All subjects were Han Chinese. The fixed-effects model and random-effects model were applied for dichotomous outcomes to combine the results of the included studies. The results revealed a trend towards an increased risk of T2DM for the SNP+45G allele as compared with the SNP+45T allele (OR = 1.34; 95% CI, 1.11–1.62; P<0.01) in the Chinese Han population. However, there was no association between SNP+276 and T2DM (OR = 0.90; 95% CI, 0.73–1.10; P = 0.31). The results of our association study showed there was no association between the adiponectin SNP+276 polymorphism and T2DM in the Yunnan Han population. The meta-analysis results suggested that the SNP+45G allele might be a susceptibility allele for T2DM in the Chinese Han population. However, we did not observe an association between SNP+276 and T2DM.

show abstract

Association of adipose most abundant transcript 1 gene (apM1) with type 2 diabetes mellitus in a Chinese population: a meta‐analysis of case‐control studies

Abstract: This apM1 polymorphism was found to be strongly associated with T2DM, and the SNP45TG + GG and SNP276GG forms of the apM1 increased risk for T2DM in Chinese populations.

Cited by 14 publications

References 8 publications

Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population

Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population

Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, −11377C>G, −11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis

Association of Adiponectin SNP+45 and SNP+276 with Type 2 Diabetes in Han Chinese Populations: A Meta-Analysis of 26 Case-Control Studies

Contact Info

Product

Resources

About