2001
DOI: 10.1016/s0140-6736(01)06581-3
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Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care

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Cited by 344 publications
(225 citation statements)
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“…The relevance of these issues is debatable, as a recent study suggests that, within a North American population, there is no difference in the prevalence of celiac disease in non-constipated IBS patients compared with controls, 35 and previous studies that have applied a routine panel of blood tests or small bowel investigations in patients with suspected IBS demonstrate a yield for organic disease of ≤1%. 13,36,37 In a previous meta-analysis of four validation studies of the Manning criteria for IBS, 19, 27-29 containing a total of 574 patients, the positive and negative LRs of the Manning criteria were 2.9 and 0.29 respectively. 26 The Manning criteria performed best in the original validation study, 19 and when this study was excluded from the analysis the positive and negative LRs fell to 2.7 and 0.33.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The relevance of these issues is debatable, as a recent study suggests that, within a North American population, there is no difference in the prevalence of celiac disease in non-constipated IBS patients compared with controls, 35 and previous studies that have applied a routine panel of blood tests or small bowel investigations in patients with suspected IBS demonstrate a yield for organic disease of ≤1%. 13,36,37 In a previous meta-analysis of four validation studies of the Manning criteria for IBS, 19, 27-29 containing a total of 574 patients, the positive and negative LRs of the Manning criteria were 2.9 and 0.29 respectively. 26 The Manning criteria performed best in the original validation study, 19 and when this study was excluded from the analysis the positive and negative LRs fell to 2.7 and 0.33.…”
Section: Discussionmentioning
confidence: 99%
“…7 Individuals with IBS are more likely to consume health care resources than healthy individuals, 8 with up to 80% of sufferers consulting their primary care physician as a result of symptoms. 9,10 Diagnosing IBS can be challenging due to overlap between the symptoms that sufferers report and those of organic GI conditions such as celiac disease, [11][12][13] small intestinal bacterial overgrowth, 14 bile acid diarrhea, 15,16 exocrine pancreatic insufficiency, 17 or inflammatory bowel disease. 18 Partly as a result of this uncertainty, symptom-based diagnostic criteria were developed for use by physicians consulting with patients with suspected IBS as early as the 1970s, with Manning et al reporting six symptoms that were commoner among individuals found ultimately to have IBS after investigation.…”
Section: Introductionmentioning
confidence: 99%
“…39 Irritable bowel syndrome, common in the general population, can hide a condition of gluten-sensitive enteropathy. 40 Atypical CD can also present with only psychiatric and neurological symptoms. In the former group, depression and anxiety have been reported, 41 whereas in the latter there are a number of idiopathic neurological disorders, such as epilepsy with and without parieto-occipital calcifications, cerebellar ataxia, intellectual deterioration with attention/memory impairment, brain atrophy, peripheral neuropathy, multiplex myoclonus (Friedreich's disease) and multiple sclerosis.…”
Section: Introductionmentioning
confidence: 99%
“…What is intriguing is that within this study Cash et al ( 23 )found that in their cohort of IBS patients, despite only 0.41 % being found to have CD, just over 7 % had CD-associated antibodies, predominantly IgG antigliadin antibodies (AGA) (4.88 % ) and IgA AGA (1.63 % ). Our group has previously reported that AGA were present in ~ 12 % of the general population and ~ 17 % in IBS (both in the presence of a normal small bowel biopsy) ( 10,14 ). Furthermore, Kaukinen et al ( 24 ) noted that the majority of patients with cereal induced (to gluten) on small bowel aspirate to defi ne an IBS subgroup ( n = 26).…”
Section: What Is the Relationship Between Ibs And Celiac Disease?mentioning
confidence: 90%