Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder

Kitamura, Soichiro; Makinodan, Manabu; Matsuoka, Kiwamu; Takahashi, Masato; Yoshikawa, Hiroaki; Ishida, Rio; Kishimoto, Naoki; Yasuno, Fumihiko; Yasuda, Yuka; Hashimoto, Ryota; Miyasaka, Toshiteru; Kichikawa, Kimihiko; Kishimoto, Toshifumi

doi:10.1002/aur.2558

Cited by 13 publications

(13 citation statements)

References 42 publications

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“…The atypical connectivity between precuneus and Broca might provide a possible proof for the dysfunction of language in ASD. Recent studies have also found the abnormality of bilateral precuneus in ASD (Kitamura et al, 2021;Lukito et al, 2020). Similar to the prior research (Lukito et al, 2020), our results also showed the increased FC in left precuneus in ASD.…”

Section: Altered Fc Between Broca Area and The Whole Brain In The Con...supporting

confidence: 92%

The Atypical Functional Connectivity of Broca Area at Multiple Frequency Bands in Autism Spectrum Disorder

Zhan

Gao

Huang

et al. 2022

Preprint

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As a developmental disorder, autism spectrum disorder has drawn much attention due to its severe impacts on language capacity. Broca area, an important brain region of language network, has largely involved in language-related functions. Using Autism Brain Image Data Exchange (ABIDE) dataset, a total of 1454 participants (618 ASD and 836 HCs) were included in our research. In order to detect the pathophysiological mechanism of autism spectrum disorder from the perspective of language, we conducted a functional connectivity analysis with Broca as the seed in multiple frequency bands (conventional: 0.01–0.08 Hz; slow-4: 0.027–0.073 Hz; slow-5: 0.01–0.027 Hz). We found that compared with healthy controls, patients with autism spectrum disorder have demonstrated increased functional connectivity in left thalamus, left precuneus, left anterior cingulate and paracingulate gyri, and left medial orbital of the superior frontal gyrus in conventional frequency band (0.01-0.08Hz). The results of slow-5 frequency band (0.01-0.027Hz) presented increased functional connectivity values of left precuneus, left medial orbital of the superior frontal gyrus, right medial orbital of the superior frontal gyrus and right thalamus. No significant cluster was detected in the slow-4 frequency band (0.027-0.073Hz). In conclusion, the abnormal functional connectivity in patients with autism spectrum disorder has frequency-specific properties. Furthermore, the findings of conventional frequency bands (0.01-0.08Hz) were mainly contributed by slow-5 (0.01-0.027Hz). The current study might shed new light on the pathophysiological mechanism of language impairments in autism spectrum disorder.

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Section: Altered Fc Between Broca Area and The Whole Brain In The Con...supporting

confidence: 92%

The Atypical Functional Connectivity of Broca Area at Multiple Frequency Bands in Autism Spectrum Disorder

Zhan

Gao

Huang

et al. 2022

Preprint

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“…Decreased FC between right precuneus with other brain regions was found in ASD [29,46]. In addition to rs-fMRI evidence, there were structure [47][48][49] and task-fMRI studies [50,51] emphasize the role of right precuneus in ASD. Despite the heterogeneity of DMN in different studies, ndings generally indicated hypoactivation of DMN nodes in ASD [52].…”

Section: Discussionmentioning

confidence: 99%

The specific brain imaging alteration underlying the autistic traits in children with attention-deficit/hyperactivity disorder

Liu

et al. 2023

Preprint

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Object: Autistic traits (ATs) were frequently reported in children with attention-deficit/hyperactive disorder (ADHD). This study aimed to examine ATs in children with ADHD from both behavioral and neuroimaging aspects. Method: The Autism Spectrum Screening Questionnaire was used to assess and define subjects with and without ATs. For the behavioral analyses, 67 ADHD children with ATs (ADHD+ATs), 105 ADHD children without ATs (ADHD-ATs), and 44 typically developing controls (CONs) were recruited. The resting-state functional MRI data were collected and the mean ALFF (mALFF) values were analyzed in a subsample. The ‘brain-behavior’ relationship was explored to illustrate the potential shared and distinct imaging features for ATs and ADHD symptoms. Result:Compared to ADHD-ATs, the ADHD+ATs group showed higher ATs and hyperactivity/impulsivity. Partial correlation analysis indicated hyperactive/impulsive significantly positively correlated with all aspects of ATs in ADHD. Imaging analyses indicated that mALFF values in left middle occipital gyrus (MOG), left parietal lobe (PL)/precuneus and left middle temporal gyrus (MTG) might be specifically related to ADHD, while that of right MTG might be more closely related to ATs. Meanwhile, the altered mALFF in right PL/precuneus was correlated with both ADHD and ATs, whereas with diverse direction. Conclusion:The co-occurrence of ATs in children with ADHD indicated different behavioral characteristics and potentially specific brain functional alterations. The assessment of ATs in children with ADHD could help us to understand the heterogeneity of ADHD, and further improve the exploration of its pathogenesis and promote clinical intervention.

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“…In conjunction with behavioral findings, this suggests that it is the changes to inter-region communication with the hippocampus that leads to spatial integration deficits, not necessarily hippocampal volume per se . In addition, spatial processing deficits were associated with abnormal cortical volume in regions implicated in spatial manipulation (larger superior parietal lobule; Gogos et al, 2010 ) and intrusive re-experiencing (smaller precuneus; Kitamura et al, 2021 ). Smaller precuneus volumes have also previously been shown to be associated with reduced spatial aspects of personal memories ( Hebscher et al, 2018 ) and disruption of precuneal activity causes network-wide disruption of the autobiographical recollection network and reduced vividness of retrieved memories ( Hebscher et al, 2019 , 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Scene Construction and Spatial Processing in Post-traumatic Stress Disorder

Marlatte

Beaton

Adler-Luzon

et al. 2022

Front. Behav. Neurosci.

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IntroductionPost-traumatic stress disorder (PTSD) is associated with hippocampal system structural and functional impairments. Neurobiological models of PTSD posit that contextual memory for traumatic events is impaired due to hippocampal system dysfunction whilst memory of sensory details is enhanced due to amygdalar impact on sensory cortices. If hippocampal system dysfunction is a core feature of PTSD, then non-traumatic hippocampal-dependent cognitive functions such as scene construction, spatial processing, and memory should also be impaired in individuals with PTSD.MethodsForty-six trauma survivors, half diagnosed with PTSD, performed two tasks that involved spatial processing. The first was a scene construction task which requires conjuring-up spatially coherent multimodal scenarios, completed by all participants. Twenty-six participants (PTSD: n = 13) also completed a navigation task in a virtual environment, and underwent structural T1, T2 and diffusion-tensor MRI to quantify gray and white matter integrity. We examined the relationship between spatial processing, neural integrity, and symptom severity in a multiple factor analysis.ResultsOverall, patients with PTSD showed impaired performance in both tasks compared to controls. Scenes imagined by patients were less vivid, less detailed, and generated less sense of presence; importantly they had disproportionally reduced spatial coherence between details. Patients also made more errors during virtual navigation. Two components of the multiple factor analysis captured group differences. The first component explained 25% of the shared variance: participants that constructed less spatially coherent scenes also made more navigation errors and had reduced white matter integrity to long association tracts and tracts connecting the hippocampus, thalamus, and cingulate. The second component explained 20% of the variance: participants who generated fewer scene details, with less spatial coherence between them, had smaller hippocampal, parahippocampal and isthmus cingulate volumes. These participants also had increased white matter integrity to the right hippocampal cingulum bundle.ConclusionOur results suggest that patients with PTSD are impaired at imagining even neutral spatially coherent scenes and navigating through a complex spatial environment. Patients that showed reduced spatial processing more broadly had reduced hippocampal systems volumes and abnormal white matter integrity to tracts implicated in multisensory integration.

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Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder

Cited by 13 publications

References 42 publications

The Atypical Functional Connectivity of Broca Area at Multiple Frequency Bands in Autism Spectrum Disorder

The Atypical Functional Connectivity of Broca Area at Multiple Frequency Bands in Autism Spectrum Disorder

The specific brain imaging alteration underlying the autistic traits in children with attention-deficit/hyperactivity disorder

Scene Construction and Spatial Processing in Post-traumatic Stress Disorder

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