Association of Age and Hospitalization Amongst Those with Underlying High-risk Conditions at COVID-19 Diagnosis in a Large, State-wide Health System

Watanabe, Jonathan H.; Kwon, Jimmy; Mehta, Sanjay R.

doi:10.1007/s11606-021-06942-y

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…In line with previous reports, our data also suggested as mentioned above, that older individuals are at higher risk to develop severe COVID-19. The importance of age in COVID-19 severity might be associated, as suggested elsewhere, with a greater prevalence of comorbidities in older patients ( 67 – 71 ). Our data could, however, not identify a significant correlation between Ascaris antibody expression and age.…”

Section: Discussionmentioning

confidence: 69%

Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin

Adjobimey,

Meyer,

Hennenfent

et al. 2023

Front. Immunol.

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IntroductionThe COVID-19 pandemic has had devastating effects worldwide, but the trajectory of the pandemic has been milder in Low-and-Middle-Income Countries (LMICs), including those in Africa. Co-infection with helminths, such as Ascaris lumbricoides, has been suggested as a possible factor contributing to the reduced severity observed in these regions.MethodsThe present study investigated the association between Ascaris-specific antibody levels and COVID-19 severity in 276 SARS-CoV-2-infected individuals in Benin. Participants were categorized into asymptomatic (n=100), mild (n=150), and severe (n=26) groups based on clinical disease severity. Sera were collected and analyzed using ELISA to measure Ascaris and SARS-CoV-2-specific antibodies, while Luminex was used to assess cytokines and SARS-CoV-2-specific neutralizing antibody expression.Results and discussionThe results demonstrated that asymptomatic SARS-CoV-2 seropositive individuals expressed, on average, 1.7 and 2.2-times higher levels of Ascaris antibodies compared to individuals with mild and severe COVID-19, respectively. This finding suggests an inverse correlation between Ascaris antibody levels and COVID-19 severity. Notably, logistic regression analysis showed that Ascaris seropositivity was significantly associated with a reduced risk of severe COVID-19 (OR = 0.277, p = 0.021). Interestingly, COVID-19 patients with comorbidities such as type 2 diabetes and high blood pressure showed lower expression of Ascaris antibodies. Strikingly, no correlation was observed between Ascaris antibody levels and SARS-CoV-2-specific neutralizing antibodies. On the other hand, individuals seronegative for Ascaris displayed significantly higher levels of systemic pro-inflammatory markers compared to seropositive individuals. These findings suggest that higher expression of Ascaris antibodies is associated with asymptomatic SARS-CoV-2 infections and may contribute to the reduction of the risk to develop severe COVID-19. The beneficial effect of Ascaris seropositivity on COVID-19 outcomes in Benin may be attributed to a decrease in comorbidities and pro-inflammatory markers. These observations provide valuable insights into the milder COVID-19 trajectory observed in Africa and may have implications for future therapeutic strategies.

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Section: Discussionmentioning

confidence: 69%

Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin

Adjobimey,

Meyer,

Hennenfent

et al. 2023

Front. Immunol.

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“…In addition, most of the elderly underwent hospital treatment in the ward and ICU. While studying the probabilities of hospitalization according to age, Watanabe et al [ 27 ] found that older adults suffered more from hospitalizations. The literature also shows that older patients presented spirometry results of less than six months with significantly more alterations [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Radiological and Functional Pulmonary Evolution in Post-COVID-19 Patients: An Observational Study

Cavallari Strozze Catharin,

Zutin,

Guiguer

et al. 2023

Diseases

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COVID-19 has generated a scenario for global health with multiple systemic impairments. This retrospective study evaluated the clinical, radiological, and pulmonary functional evolution in 302 post-COVID-19 patients. Regarding post-COVID-19 pulmonary symptoms, dry cough, dyspnea, and chest pain were the most frequent. Of the associated comorbidities, asthma was more frequent (23.5%). Chest tomography (CT) initially showed a mean pulmonary involvement of 69.7%, and evaluation in the subsequent months showed improvement in the evolutionary image. With less than six months post-pathology, there was a commitment of 37.7% from six to twelve months it was 20%, and after 12 months it was 9.9%. As for most of the sample, 50.3% of the patients presented CT normalization less than six months after infection, 23% were normalized between six and twelve months, and 5.2% presented with normalized images after twelve months, with one remaining. A percentage of 17.3% maintained post-COVID-19 pulmonary residual sequelae. Regarding spirometry, less than six months after pathology, 59.3% of the patients presented regular exam results, 12.3% had their function normalized within six to twelve months, and 6.3% had normal exam results twelve months after their post-pathology evaluation. Only 3.6% of the patients still showed some alteration during this period.

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Association of Age and Hospitalization Amongst Those with Underlying High-risk Conditions at COVID-19 Diagnosis in a Large, State-wide Health System

Cited by 2 publications

References 3 publications

Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin

Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin

Radiological and Functional Pulmonary Evolution in Post-COVID-19 Patients: An Observational Study

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