Association of age at first birth and risk of non-alcoholic fatty liver disease in women: evidence from the NHANES

Yang, Huanhuan; Chen, Guo-Chong; Zhou, Ming-Sheng; Xie, Lei; Jin, Yuanyuan; Chen, Haotian; Chen, Ze-Kun; Kong, Yu-Hao; Yuan, C. Z.; Li, Zhihui

doi:10.1007/s12072-022-10429-1

Cited by 9 publications

(11 citation statements)

References 30 publications

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“…18 FLI is a validated index used to evaluate NAFLD non-invasively. [19][20][21][22][23]25 It is simple, cost-effective and reproducible, and can easily be adapted to identify individuals with a risk of NAFLD in clinical practice. [19][20][21][22][23][24] Although the FLI indirectly reflects the status of NAFLD, our findings might propose that a higher frequency of repeated detection of NAFLD using FLI, indicating a higher degree of NAFLD, can be used as one of the risk factors to predict the incidence risk of type 2 diabetes in young adults.…”

Section: Discussionmentioning

confidence: 99%

“…The FLI is an accurate surrogate marker and has been well-validated. [19][20][21]24,25 The selection of study subjects based on the number of health examinations might be a source of bias because men and employee subscribers would probably participate in regular health check-ups. 41 Lastly, variables on family history of type 2 diabetes and metabolic syndrome and health behaviours, including dietary factors, were not obtained.…”

Section: Discussionmentioning

confidence: 99%

“…Liver biopsy is considered the gold standard for NAFLD diagnosis, yet it is invasive with a risk of complications, hindering its application in the screening and early diagnosis of NAFLD in clinical practice 18 . FLI is a validated index used to evaluate NAFLD non‐invasively 19–23,25 . It is simple, cost‐effective and reproducible, and can easily be adapted to identify individuals with a risk of NAFLD in clinical practice 19–24 .…”

Section: Discussionmentioning

confidence: 99%

“…It is used to non‐invasively evaluate NAFLD and has been validated in the general population among Asians and Caucasians, including validation studies associated with the incidence of type 2 diabetes. This method is simple and useful for detecting NAFLD in clinical practice 19–25 …”

Section: Introductionmentioning

confidence: 99%

“…This method is simple and useful for detecting NAFLD in clinical practice. [19][20][21][22][23][24][25] This study aimed to investigate the impact of repeated detection of NAFLD using the FLI on the incidence risk of type 2 diabetes in young adults using data from the Korean National Health Insurance Service (NHIS) database.…”

mentioning

confidence: 99%

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Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults

Kim,

Lyu,

Kim

et al. 2023

Diabetes Obesity Metabolism

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AimThis study aimed to investigate the effects of repeated detection of non‐alcoholic fatty liver disease (NAFLD) on the incidence risk of type 2 diabetes in young adults.Materials and MethodsIn this nationwide population‐based observational study using data from the Korean National Health Insurance Service, approximately 1 125 015 young adults aged 20‐39 years who underwent health screening four times between 2009 and 2013 were included. NAFLD was defined as a fatty liver index (FLI) of ≥60. Repeated detection of NAFLD scores was defined as the number of times the participants met the criteria for NAFLD (0‐4). To account for the degree of repeated detection of NAFLD, weighted repeated NAFLD scores were scaled as a sum by assigning points (0 points for FLI <30, 1 point for 30 ≤ FLI < 60, and 2 points for FLI ≥60) ranging from 0 to 8 points.ResultsThe multivariable‐adjusted hazard ratios of type 2 diabetes associated with repeated detection of NAFLD scores of 1, 2, 3 and 4 were 2.74 (95% confidence interval 2.57‐2.921), 3.45 (3.221‐3.694), 4.588 (4.303‐4.892) and 6.126 (5.77‐6.504), respectively. The incidence risk of type 2 diabetes increased significantly with repeated detection of the NAFLD score. In the analysis of the weighted repeated NAFLD score, the hazard ratios for the incidence of type 2 diabetes showed a significant continuous positive linear association with increasing scores.ConclusionsRepeated detection of NAFLD influenced the incidence risk of type 2 diabetes in young adults, and a higher degree of repeated detection of NAFLD was independently associated with the risk of type 2 diabetes in young adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults

Kim,

Lyu,

Kim

et al. 2023

Diabetes Obesity Metabolism

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Association Between Age at First Birth and Long-Term Dental Caries Experience Among Women in the United States

Liang,

Aris

2024

Journal of Women's Health

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The association of female reproductive factors with risk of metabolic syndrome in women from NHANES 1999–2018

Zuo,

Ge,

et al. 2023

BMC Public Health

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Background Female reproductive factors such as age at first birth (AFB), age at last birth (ALB), number of pregnancies and live births play an essential role in women’s health. However, few epidemiological studies have evaluated the association between female reproductive factors and metabolic syndrome (MetS). We therefore conducted a cross-sectional study to investigate the association between MetS risk and female reproductive factors. Methods We investigated the relationship between AFB, ALB, number of pregnancies and live births and the incidence of MetS using publicly available data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Weighted multivariable logistic regression analysis, restricted cubic spline (RCS) model, and subgroup analysis were used to evaluate the association between AFB and ALB and the risk of MetS in women. In addition, the relationship between the number of pregnancies, live births and MetS risk was also explored. Results A total of 15,404 women were included in the study, and 5,983 (38.8%) had MetS. RCS models showed an N-shaped relationship between AFB and MetS risk, whereas ALB, number of pregnancies, and live births were linearly associated with MetS. Weighted multivariable logistic regression analysis showed that the number of live births was associated with MetS risk, with ORs of 1.18 (95% CI: 1.04, 1.35) for women with ≥ 5 deliveries compared to women with ≤ 2 births. Conclusions AFB was associated with the risk of MetS in an N-shaped curve in women. In addition, women with high live births have a higher incidence of MetS.

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Association of age at first birth and risk of non-alcoholic fatty liver disease in women: evidence from the NHANES

Cited by 9 publications

References 30 publications

Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults

Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults

Association Between Age at First Birth and Long-Term Dental Caries Experience Among Women in the United States

The association of female reproductive factors with risk of metabolic syndrome in women from NHANES 1999–2018

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