Association of Aging with Minerals in Male Japanese Adults

Yasuda, Hiroshi; Yoshida, Kazuya; Tagai, Hiroshi; Fukuchi, Katsumi; Tokuda, Ryoichi; Tsutsui, Toyoharu; Yasuda, Yoshikazu

doi:10.3793/jaam.4.38

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…The control zinc reference range of 86.3–193 ppm, its geometric mean ± 2 S.D. level, obtained from the data for healthy 436 male subjects aged 21–40 year-old was close to that for healthy female adults, as previously reported171850, furthermore almost consisting with those reported by the other research groups101112. This control zinc reference range was also almost consistent with those for nutritionally controlled children13 and for the Vancouver preschoolers aged 2–5 year-old (N = 719)28, but somewhat different from the age-matched reference data for neurotypical control children in which the 11 % participants had been medicated as reviewed by Adams30.…”

Section: Methodssupporting

confidence: 88%

Infantile zinc deficiency: Association with autism spectrum disorders

Yasuda¹,

Yoshida²,

Yasuda³

et al. 2011

Sci Rep

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Elucidation of the pathogenesis and effective treatment of autism spectrum disorders is one of the challenges today. In this study, we examine hair zinc concentrations for 1,967 children with autistic disorders (1,553 males and 414 females), and show considerable association with zinc deficiency. Histogram of hair zinc concentration was non-symmetric with tailing in lower range, and 584 subjects were found to have lower zinc concentrations than −2 standard deviation level of its reference range (86.3–193ppm). The incidence rate of zinc deficiency in infant group aged 0–3 year-old was estimated 43.5 % in male and 52.5 % in female. The lowest zinc concentration of 10.7 ppm was detected in a 2-year-old boy, corresponding to about 1/12 of the control mean level. These findings suggest that infantile zinc deficiency may epigenetically contribute to the pathogenesis of autism and nutritional approach may yield a novel hope for its treatment and prevention.

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Section: Methodssupporting

confidence: 88%

Infantile zinc deficiency: Association with autism spectrum disorders

Yasuda¹,

Yoshida²,

Yasuda³

et al. 2011

Sci Rep

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149

113

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“…), and then dissolved at 75°C with shaking for 2 h. After cooling of the solution to room temperature, internal standard (Sc, Ga, and In) solution was added and, adjusting its volume gravimetrically, the obtained solution was used for mineral analysis. The mineral concentrations were measured with inductively coupled plasma mass spectrometry (ICP-MS; Agilent-7500ce) by the internal standard method (Yasuda et al, 2005a , b , 2007 ), and are expressed as ng/g hair (ppb). For quality control of the mineral analysis, the human hair certified reference material supplied from the National Institute for Environmental Studies of Japan (NIES CRM no.…”

Section: Methodsmentioning

confidence: 99%

Association of hair iron levels with creativity and psychological variables related to creativity

Takeuchi¹,

Taki²,

Sekiguchi³

et al. 2013

Front. Hum. Neurosci.

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Creativity generally involves the conception of original and valuable ideas. Previous studies have suggested an association between creativity and the dopaminergic system, and that physical activity facilitates creativity. Iron plays a key role in the dopaminergic system and physical activity. Here, we newly investigated the associations between hair iron levels and creativity, dopamine-related traits and states [novelty seeking, extraversion, and vigor (motivational state)], as well as the physical activity level. In the present study, we addressed this issue by performing a hair mineral analysis to determine iron levels and a behavioral creativity test of divergent thinking and related psychological measures among young adults (254 men, 88 women; mean age 20.79 ± 2.03 years). Iron levels did not show any significant association with creativity but displayed significant positive associations with novelty seeking, extraversion, and physical activity level. These results may be partly congruent with the notion that iron plays a key role in the dopaminergic system and imply that iron is important for traits and physical activity, which facilitate creativity. Future interventional or longitudinal studies are warranted to identify any causal effects.

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“…), and then dissolved at 75°C with shaking for 2 h. After cooling of the solution to room temperature, internal standard (Sc, Ga, and In) solution was added and, adjusting its volume gravimetric, the obtained solution was used for mineral analysis. The mineral concentrations were measured with inductively coupled plasma mass spectrometry (ICP-MS; Agilent-7500ce) by the internal standard method [6][7][8]10], and are expressed as ng/g hair (ppb). For quality control of the mineral analysis, the human hair certified reference material supplied from the National Institute for Environmental Studies of Japan (NIES CRM no.…”

Section: Hair Mineral Analysismentioning

confidence: 99%

Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and minerals

Yasuda¹,

Yoshida²,

Segawa³

et al. 2009

Environ Health Prev Med

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Objectives The objective of this metallomics study is to investigate comprehensively some relationships between cancer risk and minerals, including essential and toxic metals. Methods Twenty-four minerals including essential and toxic metals in scalp hair samples from 124 solid-cancer patients and 86 control subjects were measured with inductively coupled plasma mass spectrometry (ICP-MS), and the association of cancer with minerals was statistically analyzed with multiple logistic regression analysis. Results Multiple logistic regression analysis demonstrated that several minerals are significantly correlated to cancer, positively or inversely. The most cancer-correlated mineral was iodine (I) with the highest correlation coefficient of r = 0.301, followed by arsenic (As; r = 0.267), zinc (Zn; r = 0.261), and sodium (Na; r = 0.190), with p \ 0.01 for each case. In contrast, selenium (Se) was inversely correlated to cancer (r = -0.161, p \ 0.05), followed by vanadium (V) (r = -0.128). Multiple linear regression value was highly significantly correlated with probability of cancer (R 2 = 0.437, p \ 0.0001), and the area under the receiver-operating characteristic (ROC) curve was calculated to be 0.918. In addition, using contingency table analysis and the chi-square test, the precision of discrimination for cancer was estimated to be 0.871 (chi-square = 99.1, p \ 0.0001). Conclusions These findings suggest that some minerals such as arsenic, selenium, and probably iodine, zinc, sodium, and vanadium contribute to regulation of cancer and also that metallomics study using multiple logistic regression analysis is a useful tool for estimating cancer risk.

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Association of Aging with Minerals in Male Japanese Adults

Cited by 9 publications

References 29 publications

Infantile zinc deficiency: Association with autism spectrum disorders

Infantile zinc deficiency: Association with autism spectrum disorders

Association of hair iron levels with creativity and psychological variables related to creativity

Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and minerals

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