Association of alcohol drinking with incident type 2 diabetes and pre‐diabetes: The Guangzhou Biobank Cohort Study

Abstract

Background To examine associations of baseline alcohol drinking with incident type 2 diabetes or impaired fasting glucose, and explore whether the associations were modi ed by genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B).Methods Information of alcohol consumption was collected at baseline from 2003 to 2008. Incident type 2 diabetes was de ned as fasting glucose ≥7.0 mmol/l or post-load glucose ≥11.1 mmol/l at follow-up examination (2008)(2009)(2010)(2011)(2012), self-reported type 2 diabetes and/or initiation of hypoglycemia medication or insulin during follow-up. Impaired fasting glucose was de ned as fasting glucose ≥5.6 mmol/l and <7 mmol/l. ResultsOf 15,716 participants without diabetes and 11,232 participants without diabetes and impaired fasting glucose at baseline, 1,624 (10.33%) developed incident type 2 diabetes, and 1,004 (8.94%) developed incident impaired fasting glucose during average 4 years of follow-up. After adjusting for sex, age, education, occupation, personal annual income, smoking, physical activity, body mass index, waist/hip ratio, health status, family history of diabetes, compared with never drinking, occasional or moderate alcohol drinking was not associated with risk of incident type 2 diabetes+impaired fasting glucose (odds ratio (OR) 1.08, 95% con dence interval (CI) 0.94-1.25, and 0.89 (0.68-1.16), respectively), but heavy alcohol drinking was associated with a higher risk of incident type 2 diabetes+impaired fasting glucose (1.83, 1.25-2.69). No interactions of sex, overweight/obesity and genetic polymorphisms of ADH1B or ALDH2 genes with alcohol drinking on incident type 2 diabetes and/or impaired fasting glucose were found (p for interaction from 0.12 to 0.81).Conclusions Our results support a detrimental effect of heavy alcohol use on impaired fasting glucose and type 2 diabetes. No protective effect was found for those carrying lower risk alleles for ADH1B and ALDH2 genes.

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

“…Covariates were selected based on known confounders for the study association and risk factors for the study outcomes 30 , 42 – 50 , including demographic factors such as maternal age 47 , 51 – 53 , infant sex (as directly recorded by clinicians) 54 , socioeconomic status 55 , 56 , birth year, multifetal pregnancies 57 and other maternal factors including smoking 44 , 47 , 58 , 59 , alcohol consumption 47 , 60 , 61 , psychiatric and neurological conditions 47 , 48 , 62 – 64 , other chronic medical conditions (hypertension 51 , 65 , renal disease, inflammatory bowel disease 66 , 67 , autoimmune disease 46 , 68 , 69 , thyroid disorders 43 , 47 , 70 , 71 and polycystic ovary syndrome 45 , 72 , 73 ), BMI 44 , 47 , 51 , 74 and use of psychotropic medication 42 , 47 , 49 , antihypertensives, ADHD medication and known or suspected teratogenic medication. Various measures were applied as the proxy of socioeconomic status for each data source according to their respective practice (namely, median household income in Hong Kong, education level in Nordic countries, insurance fees in Taiwan and deprivation quintile in New Zealand).…”

The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis

“…Although it resulted in a significant conclusion, the sensitivity analysis and Egger’s test were positive, and the results between subgroups demonstrated an opposite trend of odds ratio (OR) value. In addition, the conclusions of several recently published articles were inconsistent with the meta-analysis ( 18 , 19 ). Besides, the most recent meta-analysis discussing ALDH2 and hypertension (Zheng et.…”

Association of combined healthy lifestyle with risk of adverse outcomes in patients with prediabetes

“…[8][9][10] Of note, previous observational studies have found favourable lifestyle behaviours including normal weight, no smoking and moderate alcohol consumption were associated with decreased risk of impaired fasting glucose (IFG). 11,12 These behaviours tend to cluster and work together within a population. However, the combined associations of these lifestyle behaviours on long-term risk of prediabetes-related adverse outcomes are not well understood.…”

“…Of note, previous observational studies have found favourable lifestyle behaviours including normal weight, no smoking and moderate alcohol consumption were associated with decreased risk of impaired fasting glucose (IFG) 11,12 . These behaviours tend to cluster and work together within a population.…”