Association of ALDH1 Promoter Polymorphisms With Alcohol-Related Phenotypes in Trinidad and Tobago*

Abstract

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Prevalence of Cancer-Associated Viral Infections in Healthy Afro-Caribbean Populations: A Review of the Literature

“…The median age for each study was calculated as follows: ([upper age -lower age]/2) + lower age. Four publications reported only the mean age (8,35,82,86). For these studies, we used the mean age as an estimate of the median age.…”

“…There were 27 studies conducted in nine countries that reported data for HBV or HCV infection (n = 100,031) (26-29, 34-40, [73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. Three different markers were utilized to evaluate exposure to HBV infection (Hepatitis B surface antigen (HBsAg); Anti-Hepatitis B surface antigen (Anti-HBsAg) and Anti-Hepatitis B core antigen (Anti-HBcAg)).…”

Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms

“…Aldh1a1 has been previously implicated in brain development [Denisenko-Nehrbass et al, 2000], schizophrenia [Galter et al, 2003], and alcoholism [Moore et al, 2007]. An intriguing finding is that of Oprm1 (opioid receptor mu 1) as a top candidate gene for bipolar.…”

Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDHIAI*4

“…The ALDH1A1*2 allele has been identified in diverse ethnic populations, including, Asians, Caucasians and African-Americans, while ALDH1A1*3 has only been discovered thus far in African-Americans, Mission Indians and Afro-Trinidadians. [3,21,24]…”

“…[23] The frequency of genotypes of alcohol metabolism in this population was unknown until recently. A study was undertaken that evaluated associations of ALDH1A1 promoter polymorphisms with alcohol-related phenotypes in this population [24]. In that study, the allele frequencies for ALDH1A1*1 , ALDH1A1*2 and ALDH1A1*3 in Afro-Trinidadians were found to be 0.941, 0.035 and 0.024, respectively, and 0.926, 0.074 and 0.000 in Indo-Trinidadians.…”