Association of allergic rhinitis, coronary heart disease, cerebrovascular disease, and all-cause mortality

Yoon, Angelina M. Crans; Chiu, Vicki; Rana, Jamal S.; Sheikh, Javed

doi:10.1016/j.anai.2016.08.021

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…14 Although allergic rhinitis represents a global healthcare problem, 15 to our knowledge, only two studies have examined the association between allergic rhinitis and mortality. 16 , 17 One study, the first National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study, did not observe that hay fever, also known as an allergic rhinitis, was associated with mortality. 16 Another study among the American population found that patients with physician-diagnosed allergic rhinitis had a significantly lower risk of all-cause mortality, 17 which is similar to our results.…”

Section: Discussionmentioning

confidence: 99%

Cedar Pollinosis and Mortality: A Population-Based Prospective Cohort Study in Japan

Mori

Wada

Konishi

et al. 2019

Journal of Epidemiology

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Section: Discussionmentioning

confidence: 99%

Cedar Pollinosis and Mortality: A Population-Based Prospective Cohort Study in Japan

Mori

Wada

Konishi

et al. 2019

Journal of Epidemiology

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“…On the contrary, a large study investigating the association of self-reported, doctor diagnosed asthma and CVD in adults followed over 14 years, showed that asthma and duration of asthma did not associate with CHD (Schanen, 2005). Similarly, patients with allergic rhinitis had lower incidence of acute MI and cerebrovascular disease in a large retrospective, population-based, matched cohort study (Yoon et al, 2016); while another study investigating 61,899 Taiwanese patients affected by rhinitis and 123,798 age-and sex-matched controls, found they had decreased risk of developing acute ischemic stroke (Tseng et al, 2015). In summary, clinical and epidemiological data so far are unresolved.…”

Section: Asthma Pathology and Cardiovascular Comorbiditymentioning

confidence: 93%

Cytokines at the Interplay Between Asthma and Atherosclerosis?

et al. 2020

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Cardiovascular disease (CVD) is an important comorbidity in a number of chronic inflammatory diseases. However, evidence in highly prevalent respiratory disease such as asthma are still limited. Epidemiological and clinical data are not univocal in supporting the hypothesis that asthma and CVD are linked and the mechanisms of this relationship remain poorly defined. In this review, we explore the relationship between asthma and cardiovascular disease, with a specific focus on cytokine contribution to vascular dysfunction and atherosclerosis. This is important in the context of recent evidence linking broad inflammatory signaling to cardiovascular events. However inflammatory regulation in asthma is different to the one typically observed in atherosclerosis. We focus on the contribution of cytokine networks encompassing IL-4, IL-6, IL-9, IL-17A, IL-33 but also IFN-g and TNF-a to vascular dysfunction in atherosclerosis. In doing so we highlight areas of unmet need and possible therapeutic implications.

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“…The impact of AR on CVD risk is controversial. For instance, one study analyzed data of 110,207 AR patients in a matched cohort from 1999 to 2012 in South Carolina (USA) 51 . It showed a lower risk for MI (HR 0.63), coronary heart disease (HR 0.81) and CVD (HR 0.67) in AR patients 51 .…”

Section: The Clinical Association Between Allergy and Atherosclerosismentioning

confidence: 99%

“…For instance, one study analyzed data of 110,207 AR patients in a matched cohort from 1999 to 2012 in South Carolina (USA) 51 . It showed a lower risk for MI (HR 0.63), coronary heart disease (HR 0.81) and CVD (HR 0.67) in AR patients 51 . In contrast, a large‐scale cohort study of ~9.5 million individuals followed from 2010 to 2018 through the Korean National Health Insurance Service 52 found an increased MI risk in AR patients (HR 1.11).…”

Section: The Clinical Association Between Allergy and Atherosclerosismentioning

confidence: 99%

The impact of type 2 immunity and allergic diseases in atherosclerosis

Fernández‐Gallego

Castillo-González

López‐Sanz

et al. 2022

Allergy

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Allergic diseases are allergen‐induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is often atherosclerosis, a disease distinguished by endothelial dysfunction, fibrofatty material accumulation in the intima of the artery wall, smooth muscle cell proliferation, and Th1 inflammation. The opposed T‐cell identity of allergy and atherosclerosis implies an atheroprotective role for Th2 cells by counteracting Th1 responses. Yet, the clinical association between allergic disease and CVD argues against it. Within, we review different phases of allergic pathology, basic immunological mechanisms of atherosclerosis and the clinical association between allergic diseases (particularly asthma, atopic dermatitis, allergic rhinitis and food allergy) and CVD. Then, we discuss putative atherogenic mechanisms of type 2 immunity and allergic inflammation including acute allergic reactions (IgE, IgG1, mast cells, macrophages and allergic mediators such as vasoactive components, growth factors and those derived from the complement, contact and coagulation systems) and late phase inflammation (Th2 cells, eosinophils, type 2 innate‐like lymphoid cells, alarmins, IL‐4, IL‐5, IL‐9, IL‐13 and IL‐17).

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Association of allergic rhinitis, coronary heart disease, cerebrovascular disease, and all-cause mortality

Cited by 20 publications

References 33 publications

Cedar Pollinosis and Mortality: A Population-Based Prospective Cohort Study in Japan

Cedar Pollinosis and Mortality: A Population-Based Prospective Cohort Study in Japan

Cytokines at the Interplay Between Asthma and Atherosclerosis?

The impact of type 2 immunity and allergic diseases in atherosclerosis

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