Association of alopecia areata with atopic dermatitis and chronic spontaneous urticaria

Magen, Eli; Chikovani, Tinatin; Waitman, Dan‐Andrei; Kahan, Natan R.

doi:10.2500/aap.2018.39.4114

Cited by 30 publications

(25 citation statements)

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“…The prevalence of asthma in hair loss patients ranged from 9.9 to 10.3%, compared to 6.5–7.7% for controls ( p ≤ 0.001–0.064) [27, 28]. No statistical association was identified in 4 other case-control studies (4,918 AA patients and 784,330 control patients) [21, 28-30].…”

Section: Resultsmentioning

confidence: 99%

“…A significant association was found between family history of atopy and allergic disorders and AA, with 28% of AA patients reporting a positive family history compared to 4% of controls ( p = 0.046) [21, 27-30]. Three cross-sectional studies regarding asthma and hair loss with a total 1,600 patients reported the prevalence of asthma among AA patients of 1.34–14.5%; however there was no reported association with early onset of AA or development of alopecia totalis or universalis [20, 31, 32].…”

Section: Resultsmentioning

confidence: 99%

“…A statistically significant association between asthma and hair loss was identified in one case-control study (3,806 AA patients and 4,060 control patients) [27]. The prevalence of asthma in hair loss patients ranged from 9.9 to 10.3%, compared to 6.5–7.7% for controls ( p ≤ 0.001–0.064) [27, 28].…”

Section: Resultsmentioning

confidence: 99%

“…Three case-control studies (6,135 AA patients and 787,810 controls) demonstrated a statistically significant associated between AR and hair loss, with a prevalence in AA patients ranging from 14.3 to 24.3% compared to 8–12.9% in controls ( p < 0.01–0.05) [21, 27, 30]. However, 2 further case-control studies (2,639 AA patients and 730 controls) did not report a statistically significant association between AR and AA [29, 28].…”

Section: Resultsmentioning

confidence: 99%

“…A strong genetic links exists between AA and atopy (AR and asthma) through the IL-13 and KIAA0350/CLEC16A susceptibility loci which have been identified in AA, as well as other autoimmune diseases [27, 48]. Additionally, AA and atopy share a Th2 cytokine pattern with increased levels of IgE, antibodies, mast cells, and eosinophils [49, 50].…”

Section: Discussionmentioning

confidence: 99%

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The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

Sung

Choi

Juhász

et al. 2019

Skin Appendage Disord

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Background: While alopecia areata (AA) has been associated with atopy, the immunological relationship is unclear, with the association of specific atopic and systemic respiratory diseases not established. The relationship between T-helper (Th)1-mediated AA and Th2-mediated atopy challenges the conventional Th1/Th2 paradigm of autoimmune disease categorization. Objectives: To determine the association between AA and atopic respiratory diseases in adults and children, and respiratory diseases in general. Method: All primary literature, excluding case reports, were identified within PubMed/MEDLINE, CINAHL, and Web of Science in May 2018 using the following search terms: “(alopecia OR hair loss) AND (respiratory OR pulmonary OR lungs OR asthma OR rhinitis OR bronchitis OR COPD OR atopy OR atopic).” Information from 32 articles meeting the inclusion and exclusion criteria was reviewed. Results: Among the 32 articles identified for inclusion, the prevalence of AA was more strongly associated with allergic rhinitis compared to asthma among pediatric and adult populations. While a significant association was identified between AA, allergic rhinitis, and a late age of onset, the association of AA and asthma remains controversial despite asthma’s prevalence among AA patients. No significant difference was identified with regard to the association of AA and non-atopic respiratory diseases between adult and pediatric patients. Conclusions: Adult and pediatric patients with AA warrant further workup for atopic respiratory diseases such as allergic rhinitis. AA may have an underlying Th2-mediated immunological component, which supports its association with atopic respiratory diseases and provides a new avenue for targeted therapies in select cases.

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