Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission

Humbel, Fabienne; Rieder, Jessica; Franc, Yannick; Juillerat, Pascal; Scharl, Michael; Misselwitz, Benjamin; Schreiner, Philipp; Begré, Stefan; Rogler, Gerhard; Känel, Roland von; Yılmaz, Bahtiyar; Biedermann, Luc

doi:10.1016/j.cgh.2019.09.022

Cited by 91 publications

(75 citation statements)

References 51 publications

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“…For example, the decreased level of phylum Deferribacteres found in EAP mice did decrease upon transplantation with EAP feces. Of particular interest, family Ruminococcaceae and Bacteroidaceae, and genus Lactobacillus, Turicibacter, and Bacteroides were reported to be associated with depression, 43‐45 which was consistent with the results of the present study. Although more evidence is needed to identify the specific microbiota that contributes to the development of CP/CPPS‐induced depression, the microbiota would be novel therapeutic targets for these patients.…”

Section: Discussionsupporting

confidence: 92%

Abnormal gut microbiota composition is associated with experimental autoimmune prostatitis‐induced depressive‐like behaviors in mice

Liu

Zhang

et al. 2020

The Prostate

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Background: Depressive symptoms are found in approximately 78% of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) patients, but the pathological mechanisms remain unknown. Increasing evidence suggests that abnormal gut microbiota may play an important role in depression. Thus, we aimed to investigate whether gut microbiota contributes to CP/CPPS-associated depression by using a mouse model of experimental autoimmune prostatitis (EAP).Methods: Male nonobese diabetic mice were immunized twice by subcutaneous injection of prostate antigen and adjuvant. Behavioral tests consisted of an open field test, sucrose preference test, forced swimming tests, and tail suspension test was used to confirm the depression-like symptoms that were induced by EAP. Then, fecal samples were collected, and 16S ribosomal RNA gene sequencing was performed to detect differences in gut microbiota composition between control and EAP group. Additionally, fecal bacteria from the control and EAP mice were transplanted into antibiotics-induced pseudo-germ-free mice to investigate the effects on host behaviors and the composition of gut bacteria.Results: EAP was successfully established and exhibited depressive-like behaviors in mice. The 16S rRNA analysis of fecal samples indicated the abnormal composition of gut microbiota in the EAP mice compared to the control mice. In the fecal microbiota transplant study, antibiotics-treated pseudo-germ-free mice presented depressive states as compared to naïve mice. Fecal bacteria transplant from EAP mice, but not from control mice, into the pseudo-germ-free mice, significantly exaggerated host depression-like behaviors. Moreover, fecal bacteria transplants from control and EAP mice induced distinct alterations in α-diversity and β-diversity indices. In all, 24 bacteria at six phylogenetic levels were remarkably changed by the fecal bacteria transplantation.Conclusions: Abnormal gut microbiota composition after EAP induction may contribute to the development of depression in mice. A therapeutic strategy that targets gut microbiota may provide an alternative treatment for alleviating this condition. K E Y W O R D Sdepression, fecal bacteria transplantation, gut microbiota, prostatitis

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Section: Discussionsupporting

confidence: 92%

Abnormal gut microbiota composition is associated with experimental autoimmune prostatitis‐induced depressive‐like behaviors in mice

Liu

Zhang

et al. 2020

The Prostate

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“…In contrast, the Desulfovibrionaceae family is reported in reduced proportions, 37 with a negative correlation between physiological distress and its abundance. 70 The genus Desulfovibrio degrades acidic mucin normally found in the colon. However, in CD patients, the mucus is mostly neutral, which can explain the reductions observed in these subjects.…”

Section: Dysbiosis Implicationsmentioning

confidence: 99%

Microbiota Insights in Clostridium Difficile Infection and Inflammatory Bowel Disease

et al. 2020

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Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation that includes Crohn´s disease (CD) and ulcerative colitis (UC). Although the etiology is still unknown, some specific factors have been directly related to IBD, including genetic factors, abnormal intestinal immunity, and/or gut microbiota modifications. Recent findings highlight the primary role of the gut microbiota closely associated with a persistent inappropriate inflammatory response. This gut environment of dysbiosis in a susceptible IBD host can increasingly worsen and lead to colonization and infection with some opportunistic pathogens, especially Clostridium difficile. C. difficile is an intestinal pathogen considered the main cause of antibiotic-associated diarrhea and colitis and an important complication of IBD, which can trigger or worsen an IBD flare. Recent findings have highlighted the loss of bacterial cooperation in the gut ecosystem, as well as the pronounced intestinal dysbiosis, in patients suffering from IBD and concomitant C. difficile infection (CDI). The results of intestinal microbiota studies are still limited and often difficult to compare because of the variety of disease conditions. However, these data provide important clues regarding the main modifications and interrelations in the complicated gut ecosystem to better understand both diseases and to take advantage of the development of new therapeutic strategies. In this review, we analyze in depth the gut microbiota changes associated with both forms of IBD and CDI and their similarity with the dysbiosis that occurs in CDI. We also discuss the metabolic pathways that favor the proliferation or decrease in several important taxa directly related to the disease.

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“…In the current study, UC patients who accompanied by depression and anxiety are found to harbor less Prevotella_9 and Erysipelotrichaceae UCG_003, but more Sellimonas in the feces. In consistency, Prevotella, which has been found to participate in various emotion-related metabolic pathways such as tryptophan and glutamate synthesis [23], is reported to be associated with lower depression and anxiety level, psychological stress and higher quality of life in IBD patients [22]. The abundance of Prevotella is reported to be associated with hippocampus's function and structure [24].…”

Section: Discussionmentioning

confidence: 99%

“…An animal study showed that biogenic lactic acid bacterium prevented IBD-like pathology and depression-like behavior in mice via decreasing the levels of rectal and hippocampal in ammatory cytokines [21]. Currently, there is only one clinical study that has investigated the relationship between gut microbiota and mental states in IBD patients at remission stage by 16S rRNA sequencing of the feces [22], while little is known about the situations in IBD patients at active stage (which is more severe and needs more attention) and its underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Crosstalk of multi-omics reveals specific characteristics in active ulcerative colitis patients with depression and anxiety

Yuan¹,

Chen²,

Duan³

et al. 2020

Preprint

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Background:Ulcerative colitis (UC) patients have a high incidence of mental disorders. The microbiota-gut-brain axis dysfunction is considered as one important pathogenesis of mental diseases. At present, little is known about how gut microbiota interact with the host in UC patients with depression and anxiety.Results: This prospective observational study enrolled 240 Chinese patients in two cohorts: the discovery cohort, including 69 active UC patients, 49 non-inflammatory bowel disease (IBD) depression and anxiety patients, and 62 healthy people, and the replication cohort of 60 active UC patients. About half of active UC patients showed symptoms of depression or anxiety. Through 16s rRNA sequencing, it was found that these UC patients accompanied with depression and anxiety had lower fecal microbial abundance with more Sellimonas , Eubacterium ventriosum group , Enterococcus , and Peptoclostridium , but less Prevotella_9 , Erysipelotrichaceae UCG_003 , Collinsella , and Dorea , compared with non-depressed/ anxious UC patients. Serum metabolome and proteome analysed using liquid chromatography/ mass spectrometry showed significantly increased glycochenodeoxycholate, stearoyllysophosphatidylcholine, and glyceryl stearates, while decreased 2'-deoxy-D-ribose and a set of immunoglobulin protein in the serum of UC patients with depression and anxiety. Through integration of multiple statistical analyses and multi-omics correlation analyses, we revealed a highly connected and comprehensive network, centring on Prevotella_9 and 1-stearoyl-sn-glycerol, composed of these bacteria, metabolites and proteins associated with UC-specific depression and anxiety.Conclusion: This study has identified a highly connected multi-omics network, composed of a set of gut microbiota, serum metabolites and proteins, specifically related to depression and anxiety in active UC. This network might influence host's mental state through mediating the effect of gut inflammation on synapse pruning in the central nervous system.

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Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission

Cited by 91 publications

References 51 publications

Abnormal gut microbiota composition is associated with experimental autoimmune prostatitis‐induced depressive‐like behaviors in mice

Abnormal gut microbiota composition is associated with experimental autoimmune prostatitis‐induced depressive‐like behaviors in mice

Microbiota Insights in Clostridium Difficile Infection and Inflammatory Bowel Disease

Crosstalk of multi-omics reveals specific characteristics in active ulcerative colitis patients with depression and anxiety

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