Association of altered gut microbiota composition with chronic urticaria

Nabizadeh, Edris; Jazani, Nima Hosseini; Bagheri, Mohammad; Shahabi, Shahram

doi:10.1016/j.anai.2017.05.006

Cited by 52 publications

(50 citation statements)

References 61 publications

(57 reference statements)

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“…At the genus level, members of the Bacteroides, Faecalibacterium, Bifidobacterium, Lactobacillus, and unidentified Ruminococcaceae were relatively lower and members of unidentified Enterobacteriaceae were relatively increased compared to healthy controls, which is partly consistent with previous studies about CU or allergic diseases (Sjogren et al, 2009;Johansson et al, 2011;Candela et al, 2012;Nabizadeh et al, 2017;Rezazadeh et al, 2018;Chiu et al, 2019). For example, Nabizadeh et al (2017) and Rezazadeh et al (2018) reported a depletion in the relative amounts of Faecalibacterium prausnitzii, Clostridia, Akkermansia muciniphila, Bifidobacterium, and Lactobacillus in CU patients. The mean of the relative amounts of Enterobacteriaceae was increased.…”

Section: Discussionsupporting

confidence: 89%

“…We previously conducted an epidemiologic investigation and found relevant evidence linking gut microbiota and CSU. Several studies have suggested that the changes in gut microbiota composition are linked to CU, including Akkermansia muciniphila, Faecalibacterium prausnitzii, the Clostridium leptum group, the Enterobacteriaceae family (Nabizadeh et al, 2017), and the Lactobacillus, Bifidobacterium, and Bacteroides genera (Rezazadeh et al, 2018); however, there is no specific mechanism by which to explore the dysbiosis of gut microbiota in the pathogenesis of CSU.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Wang

Guo

et al. 2020

Front. Cell. Infect. Microbiol.

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Chronic urticaria (CU) is defined as the continuous or intermittent presence of urticaria for a period exceeding 6 weeks and sometimes occurring with angioedema. Between 66 and 93% of patients with CU have chronic spontaneous urticaria (CSU), the precise pathogenesis of which is largely unknown. The aim of this study was to determine the relationship between gut microbiota and serum metabolites and the possible pathogenesis underlying CSU. We collected feces and blood samples from CSU patients and healthy controls and the relationship between gut microbiota and serum metabolites was assessed using 16S rRNA gene sequencing and untargeted metabolomic analyses. The CSU group exhibited decreased alpha diversity of the microbial population compared to the control group. The abundance of unidentified Enterobacteriaceae was increased, while the abundance of Bacteroides, Faecalibacterium, Bifidobacterium, and unidentified Ruminococcaceae was significantly reduced in CSU patients. The serum metabolome analysis revealed altered levels of docosahexaenoic acid, arachidonic acid, glutamate, and succinic acid, suggesting changes in unsaturated fatty acids and the butanoate metabolism pathway. The combined serum metabolomics and gut microbiome datasets were correlated; specifically, docosahexaenoic acid, and arachidonic acid were positively correlated with Bacteroides. We speculate that alterations in gut microbes and metabolites may contribute to exacerbated inflammatory responses and dysregulated immune function with or without regulatory T cell dependence in the pathogenesis of CSU.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Wang

Guo

et al. 2020

Front. Cell. Infect. Microbiol.

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“…More recent work has shown an increased frequency of dysbiosis of the gastrointestinal tract in CSU. As such there was a significantly reduced frequency of Akkermansia muciniphila , Clostridium leptum and Faecalibacterium prausnitzii in the stools of CSU patients while that of Enterobacteriaceae was unchanged [50]. Intriguingly, the number of tryptase and CD117 positive mast cells per high power field were significantly higher in patients with CSU compared to controls and adjunctive treatment with mast cell stabilisers has been suggested [51].…”

Section: Aetiological and Associated Factors In Csumentioning

confidence: 99%

Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria

Bansal

2019

Allergy Asthma Clin Immunol

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Chronic spontaneous urticaria (CSU) is often associated with organ specific autoimmunity but is rarely caused by food allergy. Colourings and preservatives in pre-packaged foods, so called pseudoallergens, have also been implicated. Factors that promote inflammation or reduce anti-inflammatory mechanisms may however, predispose susceptible individuals to CSU. Chronic underlying infection and mental and emotional stress can sometimes precede the onset of CSU and once established can exacerbate the symptoms. There is early evidence of dysbiosis within the gastrointestinal tract in people with CSU and reduced levels of vitamin D are also evident. The latter may be related to the importance of vitamin D3 in increasing T regulatory function which can control a tendency to autoimmunity. It is quite possible that a state of on-going chronic inflammation with reduced anti-oxidant mechanisms may underlie the not infrequent association between CSU and metabolic syndrome. Effective treatment of CSU should involve the use of anti-histamines, intermittent steroids and anti-IgE therapy. For recalcitrant disease immune modulatory therapy has a place. However, talking therapies that reduce stress and anxiety, vitamin D3 supplementation, correction of intestinal dysbiosis and treatment of any chronic infection should also be considered.

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“…Some patients with AU may turn into CU though the treatment protocol is the same. Compared to AU, CU is a more complex disease that may relate to imbalances in immunity, inflammation, and coagulation [2]. Although extensive studies have been done, the pathogenesis of CU is still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Whether intestinal flora imbalance results in the susceptibility to CU, few reports demonstrated it. Recently, the changes in bacterium Akkermansia muciniphila , Faecalibacterium prausnitzii , Clostridium leptum , and Enterobacteriaceae were reported in CU patients [2]. Unfortunately, the whole intestinal microbiome in CU patients is rarely being clarified.…”

Section: Introductionmentioning

confidence: 99%

Altered Gut Microbiota Diversity and Composition in Chronic Urticaria

Chen

Guo

et al. 2019

Disease Markers

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Background The pathogenesis of chronic urticaria (CU) is closely related to imbalances in immunity. The gastrointestinal microflora provides a vast and continuous stimulation for the immune system. However, the composition and diversity of gut microflora in CU patients are rarely reported. Methods 10 CU patients and 10 healthy individuals were selected in this study, and their intestinal microbiome was detected by 16S rRNA sequencing. The data were analyzed using R language software. Results 392 bacterial OTUs were common in the CU and healthy groups, but there were 159 OTUs particularly existing in the CU group, while 87 OTUs only were observed in healthy individuals. The bacterial diversity was reduced in CU patients compared with healthy individuals. The principal component analysis (PCA) and principal coordinate analysis (PCoA) revealed that the bacterial cluster in CU patients and the healthy controls were divided into different branches. Pathogenic strains including Escherichia coli were significantly higher in CU, while Faecalibacterium prausnitzii, Prevotella copri, and Bacteroides sp. were significantly lower in CU when compared with the healthy controls. CU patients with a high abundance of Escherichia coli had no ideal effect for probiotic therapy. Conclusion Our results demonstrated that the microbial composition was significantly different between CU patients and the healthy individual, which may be the reason leading to the various outcomes of probiotic treatment.

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Association of altered gut microbiota composition with chronic urticaria

Abstract: The results reveal a change of frequency and relative amounts of A muciniphila, C leptum, and F prausnitzii in patients with CU compared with healthy controls. This is the first study, to our knowledge, to show the change of microbiota composition in patients with CU.

Cited by 52 publications

References 61 publications

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria

Altered Gut Microbiota Diversity and Composition in Chronic Urticaria

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