Association of altered serum levels of Chemerin, Paraoxonase-1 (PON1), Asymmetric Dimethyl arginine (ADMA) and obesitin the development of Polycystic Ovarian Syndrome (PCOS) in Egyptian women

Abstract

Chemerinwas recently added to the adipokine family and was identified in human ovarian follicles and follicular fluid that suggests a direct correlation between chemerin and PCOS. Asymmetric dimethyl arginine (ADMA) is involved in endothelial dysfunctionthe atherogenic potential of ADMA has been investigated in young patients with PCOS. Oxidative stress is considered to be implicated in the pathophysiology of PCOS.Paraoxonase 1 (PON1) is an antioxidant enzyme and its concentration has been shown to be inversely associated with oxidative stress. Objectives: Evaluation of serum chemerin, ADMA, PON1in obese and non-obese polycystic ovarian patients to postulate their role in pathogenesis of PCOS. Methods: Ninetynuligravida women aged 20-35 (60 with PCOS and 30 controls) were recruited. Fasting blood was obtained on day 2 or 3 of the menstrual cycle. Clinical evaluation, hormonal profile, Chemerin, ADMA and PON1 were assessed. Results: There was a significant increase in serum chemerinlevels in PCOS obese group when compared with PCOS non obese patients and healthy controls non obese and obese respectively. Serum ADMA level was increased significantly in PCOS obese group as compared to the PCOS non obese group , control non obese and control obese. Paraoxonase was decreased stepwise significantly from the control non obese group and control obese group to PCOS non obese patients then PCOS obese patients to. Conclusions: it could be suggested that increased chemerin has a role in PCOS development andaltered ADMA and PON1 associated withobesity and oxidative stress may exacerbate the condition.

Changes of serum Interleukin and Chemerin levels in patients with Polycystic Ovary syndrome

“…In our study, Polycystic ovary syndrome cases had significantly higher plasma levels of chemerin, which could be explained by lower secretion of estradiol, as well as suppressed FSH-induced secretion of estradiol and progesterone in granulosa cells and prenatal follicles due to inhibition of p450scc and aromatase expression in granulosa cells and prenatal follicles. In line with previous findings, it is possible that chemerin plays a role in the development of Polycystic ovary syndrome, and that manipulating the expression or signaling of the chemerin gene could lead to new therapeutic approaches for Polycystic ovary syndrome [30].…”

Serum and follicular fluid chemerin and chemerin mRNA expression in women with polycystic ovary syndrome: Systematic review and meta‐analysis

“…In total, serum and FF chemerin levels were measured in nineteen 16‐18,32,33,35‐48 and four studies, 10,18,34,49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10,16‐18,32‐48 or Wb 49 .…”

“…In total, serum and FF chemerin levels were measured in nineteen 16‐18,32,33,35‐48 and four studies, 10,18,34,49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10,16‐18,32‐48 or Wb 49 . However, in total, five studies assessed chemerin mRNA expression in the subcutaneous and omental adipose tissues 17,32 and ovarian (granulosa cells in follicular fluid) 10,18,34 using reverse transcription‐polymerase chain reaction (RT‐PCR), due to the lack of data, only ovarian chemerin mRNA expression was analysed.…”

“…In total, serum and FF chemerin levels were measured in nineteen 16 , 17 , 18 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 and four studies, 10 , 18 , 34 , 49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10 , 16 , 17 , 18 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 or Wb.…”

“…In total, serum and FF chemerin levels were measured in nineteen 16 , 17 , 18 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 and four studies, 10 , 18 , 34 , 49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10 , 16 , 17 , 18 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 or Wb. 49 However, in total, five studies assessed chemerin mRNA expression in the subcutaneous and omental adipose tissues 17 , 32 and ovarian (granulosa cells in follicular fluid) 10 , 18 , 34 using reverse transcription‐polymerase chain reaction (RT‐PCR), due to...…”