Association of anaemia on heart failure and left ventricular function: A bidirectional Mendelian randomization study

Ying, Yuchen; Ye, Jiachun; Yuan, Zhechen; Cai, Dihui

doi:10.1002/ehf2.14579

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…The MR-Egger regression intercept was used to assess pleiotropy (P > 0.05) [31]. To explore relationships between gut microbiota and anemia based on MR results, the MR-PRESSO method from the TwoSampleMR package (in R software) was conducted to evaluate pleiotropy through the elimination of potential outliers [32]. To determine the reliability of MR outcomes, we utilized the Leave-One-Out approach as a methodological safeguard [33], which ruled out the possibility that individual SNPs in uenced causal signals.…”

Section: Sensitivity Analysesmentioning

confidence: 99%

Altered Gut Microbiota as a Potential Risk Factor for two types of anemia: insights from Mendelian randomization analysis

Zheng,

Chen,

zhao

et al. 2024

Preprint

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Background Numerous observational studies have indicated correlations between gut microbiota and anemia, specific causal relationships remain unclear. We investigated these relationships using Mendelian randomization (MR) analysis. Methods We acquired gut microbiota data at the multiple phylogenetic levels (five phyla, 10 classes, 13 orders, 26 families, 48 genera, and 105 species) from the Dutch Microbiome Project. We also gathered data on regarding iron deficiency anemia (IDA) and aplastic anemia (AA) from the Integrative Epidemiology Unit project. We performed MR analysis by methods including inverse variance weighting and median weighting. Next, we performed sensitivity analyses to assess pleiotropy and heterogeneity, ensuring result reliability. Finally, we used data from the MiBioGen consortium as a corroborating control. Results For IDA, we identified one class, one order, and three genera associated with decreased risk; three genera associated with increased risk. These included the genus Desulfovibrio (odds ratio [OR]: 0.86, P = 1.45×10^-2), genus Ruminococcus (OR: 0.87, P = 1.81×10^-3), species Streptococcus thermophilus (OR: 0.92, P = 2.08×10^-2), and species Sutterella wadsworthensis (OR: 1.18, P = 3.48×10^-3). For AA, one genus was associated with decreased risk; one phylum, one class, three orders, four families, and five genera were associated with increased risk. These included the genus Parasutterella (OR: 0.83, P = 2.65×10^-2), species Eubacterium hallii (OR: 1.22, P = 4.17×10^-2), genus Dorea (OR: 0.90, P = 3.46×10^-2), genus Anaerotruncus (OR: 1.32, P = 2.00×10^-2), genus Intestinibacter (OR: 1.24, P = 2.05×10^-2), and species Bilophila wadsworthia (OR: 1.30, P = 3.31×10^-2). Both types of anemia had a strong association with the order Clostridiales. The Dutch Microbiome Project results demonstrated superior efficacy, corroborated by data from the MiBioGen consortium. Conslusions Our MR analysis offers genetic insights into the associations between gut microbiota and both IDA and AA, providing new avenues for disease prevention and intervention.

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Section: Sensitivity Analysesmentioning

confidence: 99%

Altered Gut Microbiota as a Potential Risk Factor for two types of anemia: insights from Mendelian randomization analysis

Zheng,

Chen,

zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

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Nonlinear relationship between Hemoglobin-to-Age Ratio and all-cause mortality in patients with septic shock: A retrospective cohort study in the MIMIC-IV database

Yang,

Xue,

You

et al. 2024

PLoS ONE

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Background Previous studies have shown that both age and hemoglobin are closely associated with the prognosis of septic shock. A recent study found that hemoglobin may change with age. Hemoglobin-to-Age Ratio (HAR) takes both age and hemoglobin into consideration as essential factors. So far, the effect of HAR on the prognosis of septic shock is still unclear. This research aimed to investigate the association between the HAR and the prognosis of patients with septic shock. Methods Cox proportional hazards regression analysis, restricted cubic spline, Kaplan-Meier survivor analysis and stratified interaction analysis were used to elucidate the relationship between the HAR and prognosis of patients with septic shock. Results There is a nonlinear association between the HAR and mortality within 28 days after intensive care unit admission. When the HAR was lower than 0.13, mortality within 28 days after ICU admission decreased significantly as the HAR increased. When the HAR was higher than 0.13, the HAR was not a protective factor for mortality within 28 days after ICU admission. In patients with septic shock, the HAR was more effective in reducing the risk of death in patients with atrial fibrillation than in patients without atrial fibrillation. Conclusion There is a nonlinear association between the HAR and mortality within 28 days after intensive care unit admission. When the HAR was at a low level, mortality within 28 days after ICU admission decreased significantly as the HAR increased. When the HAR was at high levels, the HAR might not be a protective factor for mortality within 28 days after ICU admission. In patients with septic shock, the HAR was more effective in reducing the risk of death in patients with atrial fibrillation than in patients without atrial fibrillation.

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Association of anaemia on heart failure and left ventricular function: A bidirectional Mendelian randomization study

Cited by 2 publications

References 49 publications

Altered Gut Microbiota as a Potential Risk Factor for two types of anemia: insights from Mendelian randomization analysis

Altered Gut Microbiota as a Potential Risk Factor for two types of anemia: insights from Mendelian randomization analysis

Nonlinear relationship between Hemoglobin-to-Age Ratio and all-cause mortality in patients with septic shock: A retrospective cohort study in the MIMIC-IV database

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