Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis

Mohammed, Shimels Hussien; Shab‐Bidar, Sakineh; Abuzerr, Samer; Alizadeh, Shahab; Djafarian, Kurosh

doi:10.1186/s13104-019-4323-z

Cited by 22 publications

(11 citation statements)

References 29 publications

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“…There are also studies linking iron levels and total bilirubin values with SNHL. [16,17] In our study, the RBC, Htc, and Hb values were found to be significant. There was no difference between the patient groups regarding the NLR (generally high in patients with sudden SNHL) and the PDW.…”

Section: Discussionsupporting

confidence: 53%

Evaluation of hematological parameters of patients with profound unilateral and mild to profound bilateral sensorineural hearing loss

Toker¹

2021

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OBJECTIVE: This study aimed to investigate whether changes in blood cells have an effect on sensorineural hearing loss (SNHL) and compare the hematological parameters of profound unilateral and mild to profound bilateral SNHL patients and the normal population. METHODS: This retrospective study included 100 SNHL patients (81 males, 19 females; mean age: 37.8±16.8 years; range, 18 to 83 years) and 32 healthy volunteers (22 males, 10 females; mean age: 32.8±5.7 years; range 22 to 46 years) between January 2018 and February 2019. Patients who underwent pure tone audiometry and auditory brainstem response (ABR) tests for any reason and were found to have SNHL with no accompanying disease, and those that are non-smokers and without medication were included. Hematological parameters were evaluated in all three groups. RESULTS: Of the 100 SNHL patients, 59 had bilateral and 41 had profound unilateral SNHL. Among the evaluated hematological parameters, the difference in red blood cell count, hematocrit, hemoglobin, platelet distribution width, and neutrophil to lymphocyte ratio (NLR) between the groups was statistically significant (p<0.001). CONCLUSION: Erythrocyte values were high in patients with profound unilateral SNHL, whereas platelet-related values [platelet count, PDW, and platelet to lymphocyte ratio) were higher in patients with bilateral SNHL. In addition, the NLR was found to be high in these patient groups. These findings may provide a treatment target, particularly for profound unilateral SNHL, and may shed light on further studies on SNHL.

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Section: Discussionsupporting

confidence: 53%

Evaluation of hematological parameters of patients with profound unilateral and mild to profound bilateral sensorineural hearing loss

Toker¹

2021

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“…However, the main risk factors of childhood anemia are infection, poor dietary, breastfeeding, and hygiene practices. Poor socioeconomic and education statuses are often the main underlying factors leading to anemia development [1–5]. Besides, socioeconomic inequality has been shown to be linked to various poor health and nutritional outcomes, including anemia.…”

Section: Introductionmentioning

confidence: 99%

The contribution of dietary and non-dietary factors to socioeconomic inequality in childhood anemia in Ethiopia: a regression-based decomposition analysis

2019

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Objective There is a scarcity of evidence on socioeconomic inequalities of childhood anemia in Ethiopia. We determined the magnitude of socioeconomic inequality in anemia and the contribution of dietary and non-dietary factors to the observed inequality, using a nationally representative data of 2902 children included in the 2016 Ethiopian demographic and health survey. The data were collected following a multistage, stratified cluster sampling strategy. We followed the Blinder–Oaxaca regression-based approach to decompose the inequality and determine the relative contribution (%) of the dietary and non-dietary factors to the observed inequality. Result We found a significant pro-poor socioeconomic inequality in childhood anemia in Ethiopia. A third (~ 33%) of the inequality was attributable to compositional differences in the dietary determinants of anemia (dietary diversity, meal frequency, and breastfeeding factors). Non-dietary factors like residence place, maternal education, and birth weight) jointly explained ~ 36% of the inequality. Maternal education was the single most important factor, accounting alone for ~ 28% the inequality, followed by rural residence (~ 17%) and dietary diversity (~ 16%). Efforts to narrow socioeconomic gaps and/or designing equity sensitive interventions by prioritizing the poor in health/nutrition interventions stands worth of consideration to reduce the burden of childhood anemia in Ethiopia and beyond.

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“…The presence of 3-OH-GA in GA-1 patients may lead to increased vulnerability of endothelial structures and subsequent vascular dysfunction. The cochlea is the end organ fed solely by vessels of the labyrinthine artery, making it vulnerable to circulation causes [ 15 ]. Like other toxic metabolic diseases affecting the auditory system, the pathophysiology of hearing loss is still unclear [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Audiological and otologic manifestations of glutaric aciduria type I

Chen

Huang

Lee

et al. 2020

Orphanet J Rare Dis

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Background Glutaric aciduria type 1 (GA-1) is a rare disease connected with speech delay and neurological deficits. However, the audiological and otologic profiles of GA-1 have not yet been fully characterized. To our knowledge, this is the largest study of comprehensive audiological and otologic evaluation in patients with GA-1 to date. Methods Thirteen patients diagnosed with GA-1 between January 1994 and December 2019 with audiological, radiological and genetic manifestations were retrospectively analyzed. Hearing tests were performed in all patients. MRI was performed for radiological evaluation. Results Hearing loss was found in 76.9% (10/13) of GA-1 patients, including slight hearing loss in 46.1% (6/13) of patients, mild hearing loss in 15.4% (2/13) of patients, and moderate hearing loss in 7.7% (1/13) of patients. Normal hearing thresholds were seen in 23% (3/13) of patients. Patients with intensive care unit (ICU) admission history showed significantly worse hearing than those without (29.17 ± 12.47 vs 13.56 ± 3.93 dB HL, 95% CI 2.92–24.70, p = 0.0176). One patient had moderate sensorineural hearing loss and a past history of acute encephalopathic crisis. No usual causative gene mutations associated with hearing loss were found in these patients. MRI showed a normal vestibulocochlear apparatus and cochlear nerve. One patient with extensive injury of the basal ganglia on MRI after acute encephalopathic crisis was found to have moderate sensorineural hearing loss. Two patients with disability scores above 5 were found to have mild to moderate hearing impairment. No obvious correlation between macrocephaly and hearing loss was found. Conclusion A high prevalence of hearing impairment is found in GA-1 patients. Adequate audiological evaluation is essential for these patients, especially for those after encephalopathic crises or with ICU admission history.

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Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis

Cited by 22 publications

References 29 publications

Evaluation of hematological parameters of patients with profound unilateral and mild to profound bilateral sensorineural hearing loss

Evaluation of hematological parameters of patients with profound unilateral and mild to profound bilateral sensorineural hearing loss

The contribution of dietary and non-dietary factors to socioeconomic inequality in childhood anemia in Ethiopia: a regression-based decomposition analysis

Audiological and otologic manifestations of glutaric aciduria type I

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