Association of Angiogenesis Related Markers With Bladder Cancer Outcomes and Other Molecular Markers

Shariat, Shahrokh F.; Youssef, Ramy; Gupta, Amit; Chade, Daher C.; Karakiewicz, Pierre I.; Isbarn, Hendrik; Jeldres, Claudio; Sagalowsky, Arthur I.; Ashfaq, Raheela; Lotan, Yair

doi:10.1016/j.juro.2010.01.018

Cited by 95 publications

(94 citation statements)

References 23 publications

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“…The selection process and reasons for exclusion have been summarized in Figure 1. From the 11 studies that were included (Bernardini et al, 2001;Theodoropoulos et al, 2004;Yang et al, 2004;Suzuki et al, 2005;Zu et al, 2006;Herrmann et al, 2007;Nadaoka et al, 2008;Szarvas et al, 2008;Pignot et al, 2009;Shariat et al, 2010;Zaravinos et al, 2012), a total of 1285 patients were analyzed. The characteristics of the selected studies are presented in Table 2.…”

Section: Study Identification and Eligibilitymentioning

confidence: 99%

“…Yu-Jing Huang, Wei-Xiang Qi, Ai-Na He, Yuan-Jue Sun, Zan Shen, Yang Yao* have recently been linked to high levels of VEGF, leading several authors to conclude that an important relationship between VEGF and prognosis exists for bladder cancer (Crew et al, 1997;Inoue et al, 2000;Bernardini et al, 2001;Theodoropoulos et al, 2004;Yang et al, 2004;Zu et al, 2006;Pignot et al, 2009;Shariat et al, 2010;Li et al, 2011). However, conflicting results were showed in other studies regarding the ability of VEGF to predict prognosis in bladder cancer (Suzuki et al, 2005;Nadaoka et al, 2008;Szarvas et al, 2008;Szarvas et al, 2009;Ma et al, 2010;Zaravinos et al, 2012).…”

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confidence: 99%

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Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Huang¹,

Qi²,

He³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Study Identification and Eligibilitymentioning

confidence: 99%

mentioning

confidence: 99%

Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Huang¹,

Qi²,

He³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…For example, bladder UC cells produce high levels of vascular endothelial growth factor (VEGF) (12), basic fibroblast growth factor (bFGF) (13), and interleukin-8 (IL-8) (14). These angiogenic factors play important roles in the promotion of angiogenesis and subsequent metastasis (15). Moreover, the expression levels of these factors correlate with tumor stage and disease outcome (6,15).…”

Section: Introductionmentioning

confidence: 99%

“…These angiogenic factors play important roles in the promotion of angiogenesis and subsequent metastasis (15). Moreover, the expression levels of these factors correlate with tumor stage and disease outcome (6,15). As a result, it is hypothesized that inhibiting angiogenesis, either alone or in combination with conventional chemotherapeutics, will improve the outcome in bladder UC patients.…”

Section: Introductionmentioning

confidence: 99%

Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder

Miyake

Fujimoto²,

Anai³

et al. 2011

Oncol Rep

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Abstract. Angiogenesis is necessary for the growth, invasion, and metastasis of solid tumors. Previous studies have shown that heme oxygenase-1 (HO-1) plays an important role in angiogenesis in both normal and cancerous cells, such as vascular endothelial cells and pancreatic cancer cells, respectively. In this study, we analyzed the role of HO-1 and other angiogenic factors in urothelial carcinoma of the bladder. Specifically, we used real-time reverse transcription polymerase chain reaction (PCR) and Western blotting to investigate the upregulation of 7 angiogenic factors, namely, HO-1, vascular endothelial growth factor (VEGF), hypoxiainducible factor (HIF)-1·, HIF-2·, cyclooxygenase-2 (COX-2), interleukin-8 (IL-8), and basic fibroblast growth factor (bFGF) under hypoxic conditions in the T24 urothelial carcinoma cell line. We also used enzyme-linked immunosorbent assay (ELISA) to measure the amount of VEGF secreted into the growth media. In addition, we administered an HO-1 inhibitor, zinc protoporphyrin IX, to mice with subcutaneous T24 tumors to assess the modulation of angiogenesis in solid tumors in vivo. We also performed immunohistochemical analyses of 23 primary bladder cancer specimens with high-grade tumors infiltrating into the stroma (pT1) for expression of HO-1, VEGF, HIF-1·, HIF-2·, COX-2, and CD31. Image analysis of CD31 staining was performed to estimate microvessel density (MVD), a measure of angiogenesis. Hypoxic conditions induced upregulation of HO-1, VEGF, HIF-1·, HIF-2·, and COX-2 in T24 cells and increased VEGF secretion, which could be suppressed by zinc protoporphyrin IX. In vivo, inhibition of HO-1 decreased tumor growth and MVD by suppressing angiogenic factors, particularly VEGF and HIF-1·. In clinical specimens of bladder cancer, high expression of HO-1 was correlated with high expression of HIF-1· (P=0.027) and high MVD (P=0.005), but not with VEGF expression (P=0.19). In conclusion, since overexpression of HO-1 promotes angiogenesis in urothelial carcinoma cells, HO-1 inhibitors could be used as novel therapeutics for urothelial carcinoma of the urinary bladder.

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“…High level of VEGF expression in tumors and in serum samples from patients with UCB also predicted poorer prognosis and increased frequency of disease recurrence (98). Altered VEGF expression has been found to be associated with advanced pathological stage and lymph node metastasis (99). It is suggested that VEGF, in combination with other angiogenic factors such as angiogenin and MMPs, may serve as a biomarker for the diagnosis and prognosis of patients with UCB.…”

Section: Angiogenesismentioning

confidence: 99%

Invasion Mechanisms of Bladder Cancer: A Molecular Review

Narter¹,

Sabuncu²

2016

jus

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ÖZBladder cancer (BC) is a very common cancer and it has high mortality rates, especially in late stages. BC is considered as a different disease in various stages and grades. Non-muscle-invasive BC and muscle-invasive BC have different properties. There are some prognostic factors for progression and recurrence rates of BC and we have some risk assessment methods. These factors are based on clinical findings and histopathological properties. We do not know which factors and molecular processes are effective in the invasion mechanism. In this review, we summarized possible invasion mechanisms of BC. KeywordsBladder cancer, invasion, metastasis, molecularMesane kanseri farklı evrelerde farklı birer hastalık gibi kabul ve tedavi edilir. Her evre tekrarlama ve ilerleme açısından farklı riskler taşır. Günümüzde bu tekrarlama ve ilerleme risklerini gösteren değişik hesaplama sistemleri tanımlansa da altta yatan moleküler, genetik ve çevresel faktörler net olarak gösterilememiştir. Mevcut risk hesaplama sistemleri klinik, makroskopik ve patolojik değerlendirme temellerine oturmaktadır. Derlemede özetlemeye çalıştığımız olası invazyon mekanizmaları aydınlatıldıkça prognostik yeni moleküler faktörlerin tanımlanması, hatta bu temelde yeni tedavi metodlarının geliştirilmesi mümkün olacaktır. Anahtar KelimelerMesane kanseri, invazyon, metastaz, moleküler IntroductionUrothelial tumors are classified as papillary and nonpapillary (solid) tumors. Histopathologically, more than 90% of bladder cancers (BCs) are urothelial (transitional) cell carcinomas (UCC or TCC). At the time of diagnosis, about 75% of BCs are non-muscle-invasive bladder cancer (NMIBC) and remaining 25% are muscle-invasive bladder cancer (MIBC). Phenotypes and genotypes of these cancers in various stages are different. In this context, 30% to 50% of NMIBCs recur after transurethral resection of the primary tumor, and 10% to 20% progress to MIBC. Many of high-grade carcinomas (including carcinoma in situ) invade the bladder wall and may metastasize to other sites. Additionally, nearly 50% of patients with MIBCs have occult distant metastases at the time of diagnosis (1,2). Recently, in the literature, there are many studies in which molecular, genetic and physical factors have been investigated in the progression and recurrence of the BC but it has not been fully outlined. All these factors affect the process of metastasis, invasion and resistance to therapy. Generally, major characteristics of malignant cancer cells are defined as self-sufficiency in growth signals, insensitivity to anti-growth signals, tissue invasion and metastasis, limitless replicative potential, sustained angiogenesis, and evading apoptosis. Additionally, tumor metastasis includes detachment, migration, invasion, intravasation, anoikis, evasion, and extravasation steps. In this review, we aimed to summarize the possible genetic, molecular and physical factors that are responsible for the progression and recurrence. Epithelial-Mesenchymal Transition and PlasticityMechanism of the...

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Association of Angiogenesis Related Markers With Bladder Cancer Outcomes and Other Molecular Markers

Cited by 95 publications

References 23 publications

Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder

Invasion Mechanisms of Bladder Cancer: A Molecular Review

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