Association of angiomyolipoma and oncocytoma of the kidney: a case report and review of the literature

Abstract

This paper presents an additional case of oncocytoma associated with angiomyolipoma. Of the 15 cases described in the literature, three were associated with the tuberous sclerosis complex, all from a single study. In tuberous sclerosis, angiomyolipomas are more commonly associated with renal cell carcinoma. If angiomyolipomas are found incidentally in nephrectomy specimens together with other tumours, it is important to exclude tuberous sclerosis retrospectively.

Extrarenal retroperitoneal angiomyolipoma with oncocytoma

“…[ 2 ] On gross examination, there is little or no evidence of necrosis or hemorrhage, occasionally a central scar is observed. [ 3 ] As it is difficult to differentiate it from renal clear cell carcinoma on imaging, nephrectomy remains the treatment of choice. [ 2 ]…”

Renal cell carcinoma in the context of tuberous sclerosis: report of a paediatric case with intra‐operative cytology, histology, immunohistochemistry and molecular cytogenetics1

“…A preliminary diagnosis of probable RCC, not otherwise specified (NOS) was advanced. The hypotheses of oncocytoma and even of oncocytoma‐like angiomyolipoma were not definitely ruled out, as angiomyolipomas concurrent with oncocytoma, CRCC or RCC, NOS have been reported in TSC 4,6–9 . Material was collected for FISH in order to look for translocations involving the TFE3/TFEB genes 10 …”

Homozygous structural rearrangement 16p13: A mechanism of tumorigenesis in sporadic renal angiomyolipoma?

“…Although controversial, it is believed to be a neoplastic process in a family of tumors called PEComas (tumors of perivascular epithelioid cells) [Hornick and Fletcher, 2006], and immunophenotypic characterization among various components suggests a common cell line [Stone et al, 2001]. AML occurs in association with hereditary disorders including tuberous sclerosis complex (TSC), von Hippel–Lindau syndrome, and autosomal dominant polycystic kidney disease; however, 80% of cases are isolated and sporadic [Nelson and Sanda, 2002; Pillay et al, 2003]. TSC‐associated angiomyolipomas are often small, multicentric and bilateral, while sporadic AML tends to be solitary.…”

“…TSC‐associated angiomyolipomas are often small, multicentric and bilateral, while sporadic AML tends to be solitary. Histologically, they cannot be distinguished one from another [Nelson and Sanda, 2002; Pillay et al, 2003]. As reviewed by Mitelman et al 2008, cytogenetic analysis of sporadic angiomyolipoma has been limited with clonal chromosomal alterations found in 7 of 19 sporadic cases.…”