Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

Abstract

Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Conclusions: D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races.

Association of Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism with Idiopathic Nephrotic Syndrome Susceptibility in Children: An Updated Meta-Analysis

“…We previously performed a meta-analysis to explore the relationship between angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism and INS susceptibility in children, and the search for this meta-analysis was conducted on 1 September 2010. 1 We found that there was a positive association between D allele/DD genotype and INS susceptibility in Asian children, but not for Caucasian children and African children. However, Prasun et al 2 reported an investigation on the association of ACE I/D gene polymorphism with INS risk in 2011, and we had not included this study into our previous meta-analysis.…”

Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects

“…There is ample evidence indicating that the ACE I/D polymorphism may modulate the expression of the ACE gene and the DD and D allele of the ACE gene which brings about higher plasma ACE levels and increased angiotensin II levels which are associated with many atopic disorders such as rheumatoid arthritis, asthma and nephrotic syndrome. 17,19,37 With regard to the correlation between genetic variants and AR susceptibility, different studies on the association between the ACE I/D polymorphism and AR risk have showed discrepancy in results. [23][24][25][26][27][28] Thus, our meta-analysis from six studies comprising 741 AR patients and 669 controls was performed to precisely assess the possible association of ACE I/D polymorphism with the susceptibility of developing AR.…”

Association of Matrix Metalloproteinase-9 Level with the Risk of Renal Involvement for Henoch–Schönlein Purpura in Children

“…The pooled statistic was counted using the fixed effects model, but a random effects model was conducted when the p-value of heterogeneity test was less than 0.1. 8,9 Results were expressed with weighted mean differences (WMDs) for continuous data, and 95% confidence intervals (CIs) were also counted. A p value <0.05 was required for the overall odds ratio (OR) to be deemed statistically significant.…”