Association of angiotensin converting enzyme gene polymorphism with tachycardia cardiomyopathy

Deshmukh, Pramod; Krishnamani, Rajan; Romanyshyn, Mary; Johnson, Andrew K.; Noti, John D.

doi:10.3892/ijmm.13.3.455

Cited by 18 publications

(13 citation statements)

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“…The dramatic difference in prognosis of TICM treated by eliminating the tachyarrhythmic substrate versus idiopathic DCM warrants diligence to rule out this important underlying cause. Data from several studies and individual case reports have shown that rhythm control results in significant improvement of ventricular systolic function and resolution of clinical signs of CHF . Follow‐up data in our study confirm the excellent long‐term prognosis for recovery from CHF and ventricular dysfunction in dogs when the tachyarrhythmia is eliminated by RFCA.…”

Section: Discussionsupporting

confidence: 80%

Atrioventricular accessory pathways in 89 dogs: Clinical features and outcome after radiofrequency catheter ablation

Wright¹,

Connor

Irvin³

et al. 2018

Veterinary Internal Medicne

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BackgroundAtrioventricular accessory pathways (APs) in dogs have been reported rarely. Data regarding clinical presentation and long‐term outcome after radiofrequency catheter ablation (RFCA) are limited.Hypothesis/ObjectivesTo study clinical features, electrophysiologic characteristics, and outcome of RFCA in dogs with APs.AnimalsEighty‐nine dogs presented consecutively for RFCA of APs.MethodsCase series.ResultsLabrador retrievers (47.2% of dogs) and male dogs (67.4% of dogs) were most commonly affected. Labrador retrievers were more likely to be male than non‐Labrador breeds (P = .043). Clinical signs were nonspecific and most commonly included lethargy and gastrointestinal signs. Concealed APs were more prevalent in Labrador retrievers than other breeds (P = .001). Right‐sided APs (91.7%) predominated over left‐sided (8.3%). Tachycardia‐induced cardiomyopathy (TICM) occurred in 46.1% of dogs, with complete resolution or substantial improvement noted on one‐month postablation echocardiograms. Radiofrequency catheter ablation successfully eliminated AP conduction long term in 98.8% of dogs in which it was performed. Complications occurred in 5/89 dogs. Recurrence in 3 dogs was eliminated long term with a second procedure.Clinical Importance/ConclusionsAccessory pathways are challenging to recognize in dogs because of nonspecific clinical signs, frequency of concealed APs that show no evidence of their presence during sinus rhythm, and intermittent occurrence of tachyarrhythmias resulting from APs. Tachycardia‐induced cardiomyopathy commonly occurs with AP‐mediated tachycardias and should be considered in any dog presenting with a dilated cardiomyopathic phenotype because of its good long‐term prognosis with rhythm control. Radiofrequency catheter ablation is a highly effective method for eliminating AP conduction and providing long‐term resolution.

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Section: Discussionsupporting

confidence: 80%

Atrioventricular accessory pathways in 89 dogs: Clinical features and outcome after radiofrequency catheter ablation

Wright¹,

Connor

Irvin³

et al. 2018

Veterinary Internal Medicne

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“… 10 There is growing interest in the genetic basis of tachycardia-induced CM, as individuals with a specific angiotensin-converting enzyme gene polymorphism may be more susceptible but further study is still required. 11 …”

Section: Arrhythmogenic (Tachycardia-induced) Cardiomyopathymentioning

confidence: 99%

Reversible Cardiomyopathies

Patel

Madanieh

Kosmas

et al. 2015

Clin Med Insights Cardiol

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Cardiomyopathies (CMs) have many etiological factors that can result in severe structural and functional dysregulation. Fortunately, there are several potentially reversible CMs that are known to improve when the root etiological factor is addressed. In this article, we discuss several of these reversible CMs, including tachycardia-induced, peripartum, inflammatory, hyperthyroidism, Takotsubo, and chronic illness–induced CMs. Our discussion also includes a review on their respective pathophysiology, as well as possible management solutions.

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“…Looking at the prevalence of this polymorphism among 20 patients with tachycardia-induced cardiomyopathy as compared to another sample of 20 patients without this pattern, the authors reported a higher detection of this ACE polymorphism in the cardiomyopathic group [59].…”

Section: Pathophysiology Of Tachycardia-induced Cardiomyopathymentioning

confidence: 96%

“…An observation that tachycardia-induced cardiomyopathy does not evolve in every patient with the same type, duration and rate of a tachycardia implies possible genetic predisposition of some patients to develop a dilated cardiomyopathy pattern during tachycardia. In fact, one study [59] suggests that polymorphism in angiotensin-converting enzyme (ACE) gene may be involved, since one type of such polymorphism (which is associated with higher serum levels of ACE) is more frequently linked to idiopathic and ischemic cardiomyopathy manifestation.…”

Section: Pathophysiology Of Tachycardia-induced Cardiomyopathymentioning

confidence: 99%

Tachycardia-induced cardiomyopathy: a review of literature on clinical status and meta-analysis of diagnosis and clinical management method

Albakri¹

2018

Integr Mol Med

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Virtually, any kind of tachycardia may lead to the development of tachycardiainduced cardiomyopathy. This term refers to left ventricular dysfunction and dilated cardiomyopathy pattern that occur as a consequence of persistent tachycardia. Impaired left ventricular function in the presence of tachycardia can be found accidentally, but it is often associated with progressive symptoms and signs of heart failure that force the individual to seek medical help. A hallmark of tachycardiainduced cardiomyopathy is the reversibility of both hemodynamic and structural changes after cessation of the index tachycardia. However, contractile dysfunction and structural changes may persist even weeks after the rhythm/rate correction. Therefore, tachycardia-induced cardiomyopathy should be considered as a probable reason of ventricular dysfunction and dilatation in any patient presenting with dilated cardiomyopathy pattern, despite that the initial rhythm is not pathological or the heart rate is well controlled. This review summarizes our current knowledge about this specific form of cardiomyopathy.

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Association of angiotensin converting enzyme gene polymorphism with tachycardia cardiomyopathy

Cited by 18 publications

References 0 publications

Atrioventricular accessory pathways in 89 dogs: Clinical features and outcome after radiofrequency catheter ablation

Atrioventricular accessory pathways in 89 dogs: Clinical features and outcome after radiofrequency catheter ablation

Reversible Cardiomyopathies

Tachycardia-induced cardiomyopathy: a review of literature on clinical status and meta-analysis of diagnosis and clinical management method

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