Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population

Firouzabadi, Negar; Shafiei, Massoumeh; Bahramali, Ehsan; Ebrahimi, Soltan Ahmad; Bakhshandeh, Hooman; Tajik, Nader

doi:10.1016/j.psychres.2012.05.002

Cited by 48 publications

(33 citation statements)

References 46 publications

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“…Depression were also significantly associated with an increase in cortisol secretion and, it is stated that ACE gene rs4295, rs4311, rs4343, rs4291, rs4333 and rs4351 variations influence cortisol secretion 41 . ACE gene A2350G polymorphism was closely associated with MDD among Iranian population 12 .…”

Section: Discussionmentioning

confidence: 92%

“…ACE is responsible for degeneration of neurokinins that play an important role in regulation of emotions. Angiotensin II is both a potent neuropeptide and have essential roles in cognitive processes 12 . In some studies, it has been shown that ACE may contribute to the pathophysiology of psychiatric diseases by interacting with central dopamine 7 .…”

Section: Introductionmentioning

confidence: 99%

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Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Inanir¹,

Yığıt²,

Celikel³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective: The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods: In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results: Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion: Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Inanir¹,

Yığıt²,

Celikel³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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“…13 Another two found no significant associations 14, 15 and another reported inverse associations with closely linked SNPs. 16 …”

Section: Introductionmentioning

confidence: 99%

“…The inconsistencies are likely related to methodological differences including heterogeneity in terms of sample size and study design (family-based 15 vs case-control studies 12, 13, 14, 16 ), the age of the population (childhood, 15 adulthood 12, 13, 14, 16 or lifetime 17 ), depression phenotypes (unipolar and bipolar depression, 15 investigating recurrent episodes, 12, 14 or not 13, 15, 16, 17 ), as well as ethnicity (European, 12, 14, 15, 17 Thai 13 or Iranian 16 ). Three studies excluded controls with past depression and lifetime anxiety disorder, 12, 14, 17 but the genome-wide association study was the only one to also exclude controls with current depressive symptomatology.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression

et al. 2013

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Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic–pituitary–adrenocortical (HPA) axis, which shows hyperactivity in depressed patients. ACE could thus be a promising candidate gene for late-life depression but this has not been examined previously. Depression was assessed in 1005 persons aged at least 65 years, at baseline and over the 10-year follow-up. A clinical level of depression (DEP) was defined as having a score of ⩾16 on the Centre for Epidemiology Studies-Depression scale or a diagnosis of current major depression based on the Mini International Neuropsychiatric Interview and according to DSM-IV criteria. Seven single-nucleotide polymorphisms (SNPs) in the ACE gene were genotyped and diurnal cortisol secretion, as an index of HPA axis activity, was measured. Multivariable analyses were adjusted for socio-demographic and vascular factors, cognitive impairment, and apolipoprotein E. Strong significant associations were found between all seven SNPs and DEP and, in particular, first-onset DEP in persons without a past history of depression (P-values ranging from 0.005 to 0.0004). These associations remained significant after correction for multiple testing. The genotypes that were associated with an increased risk of DEP were also significantly associated with an increase in cortisol secretion under stress conditions. Variants of the ACE gene influence cortisol secretion and appear as susceptibility factors for late-life depression in the elderly population. Whether this could represent a common pathophysiological mechanism linking HPA axis and late-life depression remains to be explored.

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“…Carriers of the GG genotype of the ACE A2350G showed an association with depression, where higher serum ACE activity was seen. Furthermore, individuals with depression carrying the GC genotype of the A2350G polymorphism had significantly higher serum ACE activity [6]. …”

Section: Tablementioning

confidence: 99%

Angiotensin Converting Enzyme Inhibitors and Risk of Mood Disorders

Williams

Pasco

Kessing

et al. 2016

Psychother Psychosom

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Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population

Cited by 48 publications

References 46 publications

Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression

Angiotensin Converting Enzyme Inhibitors and Risk of Mood Disorders

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