Association of angiotensin‐converting enzyme DD genotype with 24‐h blood pressure abnormalities in normoalbuminuric children and adolescents with Type 1 diabetes

Barkai, László; Soós, Áron; Vámosi, Ildikó

doi:10.1111/j.1464-5491.2005.01601.x

Cited by 10 publications

(6 citation statements)

References 52 publications

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“…This observation has been confirmed in many studies conducted in the general population and among subjects with T2DM [6, 27, 28]. Studies performed in the pediatric population have shown that allele DD in ACE polymorphism is associated with higher BP in normotensive, normoalbuminuric diabetic children in ABPM measurements [9, 29]. Similarly in our previous study, when we have taken into account only clinically normotensive and normoalbuminuric children, we have proven that subjects in the DD genotype group had significantly higher nocturnal BP in comparison with ID/II genotype group, and this was also connected with lower dipping [10].…”

Section: Discussionsupporting

confidence: 52%

“…These polymorphisms were selected for the study based on evidence from the literature. The best known gene variant association in the ACE genes is I/D variant, with allele DD connected with potentially higher BP [4, 6, 9, 10]. Moreover, we chose to study another two single nucleotide polymorphisms (SNP) of ACE , rs1800764 and rs4459609, because they were shown to characterize the haplotypic structure of ACE in European populations [18, 19].…”

Section: Methodsmentioning

confidence: 99%

“…Some studies have shown that different polymorphisms in angiotensin 1-converting enzyme (ACE) gene are associated with development of both persistent microalbuminuria and diabetic nephropathy [5, 6]; however, other recently published reports have not replicated these findings [7, 8]. Furthermore, a few studies suggested an association between ACE genotype and tendency to higher BP in normoalbuminuric, normotensive patients during ABPM measurements in T1DM children [9, 10], but to date, there are no studies exploring this in adolescents and young adults with HT and diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes

et al. 2014

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The aim of our study was to characterize the association of clinical and genetic risk factors such as: ACE genotype (rs17997552, rs1800764, rs4459609) and RGS2 (rs2746071) with the development of hypertension (HT) and non-dipping phenomenon in patients with type 1 diabetes mellitus (T1DM). A total of 238 adolescents and young adults with T1DM—103 females and 135 males, aged 8–30 years (mean 17.35 ± 5.2) with diabetes duration 1–26 years (mean 7.72 ± 6.2), with mean HbA1c (IFCC) 58 ± 15 mmol/mmol—were subjected to 24-h ambulatory blood pressure measurements (ABPM). The results of the ABPM were analyzed in association with the polymorphisms of ACE and RGS2 genes and clinical data of patients. HT was recognized in 65 (27 %) and non-dipping in 111 (46.63 %) patients. In the multivariate analysis of factors predisposing to HT, the variables that remained significant were the following: male sex (OR 1.62; 95 % CI 1.171–2.250), non-dipping (OR 1.40; 95 % CI 1.03–1.90) and total cholesterol level (OR 1.01; 95 % CI 1.005–1.021). The only factor influencing non-dipping was the duration of diabetes—OR 1.09 (95 % CI 1.04–1.14). The patients displaying non-dipping have a twice increased risk of development of HT (OR 2.17; 95 % CI 1.21–3.89). There was no association between disturbances of blood pressure (BP) and genotypes of ACE: rs17997552, rs1800764, rs4459609 and RGS2: rs2746071. Clinical rather than genetic risk factors seem to be connected with BP disturbances in young patients with T1DM. Although we have identified representative groups of HT versus non-HT and dipping versus non-dipping subjects, the effect of genetic predisposition to the development of higher BP is too weak to be statistically significant.Electronic supplementary materialThe online version of this article (doi:10.1007/s00592-014-0568-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 52%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes

et al. 2014

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“…But it is possible to speculate that the DD genotype may provide resistance against the development of sepsis. This may be explained by the characteristics of the individuals who have the DD genotype, because they have higher systolic blood pressure levels than those with other ACE genotypes 16,17 . The lower blood pressure will generate a lower volume of blood in the peripheral parts of the body; therefore, cells will not receive enough oxygen and nutrients, and waste products will not be adequately removed, which may subsequently facilitate the development of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Role of angiotensin‐converting enzyme gene polymorphisms in children with sepsis and septic shock

Çoğulu¹,

Önay²,

Uzunkaya³

et al. 2008

Pediatrics International

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“…In the paediatric population, there is little information on the association of polymorphisms in the RAS and the development of early signs of microvascular complications. Some have demonstrated that ACE gene polymorphism is associated with BP abnormalities in normotensive and normoalbuminuric children with T1DM (40).…”

Section: Genetic Factorsmentioning

confidence: 99%

Identifying children at particular risk of long-term diabetes complications

2007

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Formerly a 'taboo' subject, long-term complications are now being increasingly discussed with the family by the health-care team. Identifying potential predictors and establishing early intervention can change the course of these complications in the young patient with diabetes. Although the most recognized risk factor is glycaemic exposure, the development of diabetes complications is likely to result from an interaction between genetic and environmental factors. Other major environmental risk factors are hypertension, smoking, higher body mass index and lipid disorders. This article will concentrate on specific paediatric aspects, including the impact of puberty; endothelial dysfunction and genetic susceptibility. Endothelial function assessed by flow-mediated dilatation is a non-invasive method that has been suitable for use in children and adolescents. In type 1 diabetes mellitus children, endothelium dysfunction has been documented among patients with short diabetes duration and has been correlated to folate status, triglyceride and low-density lipoprotein cholesterol levels. Studies in the paediatric population have also revealed an association of diabetes complications with genetic variants in the renin-angiotensin system, polyol pathway, lipid oxidation and folate metabolism. Currently, achieving the best glycaemic control remains the gold standard for prevention of long-term diabetes complications in the clinical context. However, recent identification of genetic markers and development of research tools that predict long-term complications might have a potential role as instruments in assessing the effectiveness of intervention in the early course of the disease.

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Association of angiotensin‐converting enzyme DD genotype with 24‐h blood pressure abnormalities in normoalbuminuric children and adolescents with Type 1 diabetes

Abstract: Children and adolescents with Type 1 diabetes do not differ from the non-diabetic population regarding the I/D polymorphism of the ACE gene. ACE gene polymorphism is associated with BP abnormalities in normotensive and normoalbuminuric children and adolescents with Type 1 diabetes.

Cited by 10 publications

References 52 publications

Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes

Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes

Role of angiotensin‐converting enzyme gene polymorphisms in children with sepsis and septic shock

Identifying children at particular risk of long-term diabetes complications

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