Association of angiotensin-converting enzyme gene promoter single nucleotide polymorphisms and haplotype with major depression in a northeastern Thai population

Angunsri, Rudee; Sritharathikhun, Thapanut; Suttirat, Sarawut; Tencomnao, Tewin

doi:10.1177/1470320309344151

Cited by 22 publications

(21 citation statements)

References 32 publications

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“…Regarding a point of concern, the observed difference in age between the two groups in the present study may have influenced the outcome in the association test as previously discussed (Angunsri et al, 2009). Nevertheless, it is unlikely that such an age difference could significantly alter the result of this study.…”

Section: Discussionmentioning

confidence: 69%

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Tencomnao¹,

Thongrakard²,

Phuchana³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP. We found no significant differences between the two groups with

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Section: Discussionmentioning

confidence: 69%

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Tencomnao¹,

Thongrakard²,

Phuchana³

et al. 2010

Genet. Mol. Res.

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“…ACE, membrane-bound endopeptidase, is expressed in many tissues including brain 13 . It is reported that ACE in neuroepithelial cells degrades neurotransmitters such as substance P, which has a role in depression 14 and that angiotensin II interacts with dopamine in some specific parts of brain 15 . Angiotensin II, acting as a stimulator of proinflammatory cytokines, makes changes on the hypothalamic-pituitary-adrenal (HPA) axis activation that develops in response to stress.…”

Section: Discussionmentioning

confidence: 99%

Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Inanir¹,

Yığıt²,

Celikel³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective: The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods: In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results: Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion: Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.

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“…12 Only one study involving Thai adults replicated the association between rs4291 and major depression. 13 Another two found no significant associations 14, 15 and another reported inverse associations with closely linked SNPs. 16 …”

Section: Introductionmentioning

confidence: 96%

Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression

et al. 2013

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Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic–pituitary–adrenocortical (HPA) axis, which shows hyperactivity in depressed patients. ACE could thus be a promising candidate gene for late-life depression but this has not been examined previously. Depression was assessed in 1005 persons aged at least 65 years, at baseline and over the 10-year follow-up. A clinical level of depression (DEP) was defined as having a score of ⩾16 on the Centre for Epidemiology Studies-Depression scale or a diagnosis of current major depression based on the Mini International Neuropsychiatric Interview and according to DSM-IV criteria. Seven single-nucleotide polymorphisms (SNPs) in the ACE gene were genotyped and diurnal cortisol secretion, as an index of HPA axis activity, was measured. Multivariable analyses were adjusted for socio-demographic and vascular factors, cognitive impairment, and apolipoprotein E. Strong significant associations were found between all seven SNPs and DEP and, in particular, first-onset DEP in persons without a past history of depression (P-values ranging from 0.005 to 0.0004). These associations remained significant after correction for multiple testing. The genotypes that were associated with an increased risk of DEP were also significantly associated with an increase in cortisol secretion under stress conditions. Variants of the ACE gene influence cortisol secretion and appear as susceptibility factors for late-life depression in the elderly population. Whether this could represent a common pathophysiological mechanism linking HPA axis and late-life depression remains to be explored.

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Association of angiotensin-converting enzyme gene promoter single nucleotide polymorphisms and haplotype with major depression in a northeastern Thai population

Cited by 22 publications

References 32 publications

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression

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