Association of angiotensinogen gene M235T polymorphism with the risk of IgA nephropathy: a meta-analysis

Mao, Song; Huang, Songming

doi:10.3109/0886022x.2013.868318

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…age, sex, or diagnostic criteria), or dissimilarities in study design (Bai et al, 2012). Third, diagnosis of IgAN depends on renal biopsy, meaning that those patients who did not agree to this procedure were excluded from the analysis (Mao and Huang, 2014). Finally, any potential influence of the A1166C polymorphism may be effected via gene-gene and gene-environment interactions (Qin et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Jm¹,

Song²,

Gao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a metaanalysis. Articles were identified in the PubMed, Google Scholar, and China National Knowledge Infrastructure databases, and after selection, five eligible studies were included. Statistical analyses were carried out using Stata 12.0, combining data from all the relevant studies. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 19371-19381 (2015) AC vs AA+CC: OR = 0.96, 95%CI = 0.70-1.31]. In conclusion, the AGTR1 gene A1166C polymorphism may not be correlated with IgAN susceptibility. However, further studies should be performed to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Jm¹,

Song²,

Gao³

et al. 2015

Genet. Mol. Res.

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“…Zhou et al 22 reported that no marked association between AGT M235T gene polymorphism and ESRD was observed in overall populations. Mao et al 23 reported that AGT M235T gene polymorphism was not associated with the risk of IgA nephropathy. Arfa et al 24 reported that AGT M235T gene polymorphism was not associated with the development of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Association of AGT M235T gene polymorphism with HSP/HSPN risk

Mao

Huang

2014

Renal Failure

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To evaluate the association between angiotensinogen (AGT) gene polymorphism and the risk of Henoch-Schö nlein purpura (HSP)/Henoch-Schö nlein purpura nephritis (HSPN) we searched the eligible studies through Pub Med, Embase, Cochrane, and China National Knowledge Infrastructure (CNKI) databases according to predefined criteria. A random-effects model was used to calculate the combined odds ratios (ORs) and its corresponding 95% confidence interval (CI). Five studies were recruited for the analysis of the association between AGT M235T gene polymorphism and HSP/HSPN risk. M allele was associated with lower risk of HSP in adult (p ¼ 0.050), TT genotype was associated with the susceptibility to HSP in adult (p ¼ 0.039). AGT M235T gene polymorphism was not associated with HSP risk in children. No marked association was observed between AGT M235T gene polymorphism and HSPN risk. No evidence of publication bias was observed. In conclusion, M allele might be a protective factor against the HSP risk in adult, TT genotype might be a risk factor for the susceptibility to HSP in adult. However, further larger studies should be performed in the future.

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“…Renin-angiotensin system-related genes have been postulated as candidate genes for association studies in IgAN but have yielded contradictory results [31,32,33,34,35,36,37]. Among variants in the renin-angiotensin system, insertion/deletion (I/D) polymorphisms in angiotensin-converting enzyme (ACE) genes have been observed.…”

Section: Genetic Studies Of Iganmentioning

confidence: 99%

“…Human leukocyte antigen (HLA) gene family [18,29,30], renin-angiotensin system-related [31,32,33,34,35,36,37], TRAC [38,39] and cytokine-related genes (interleukin-1, transforming growth factor-β1) [40,41] have undergone association studies to test the development and/or progression of IgAN.…”

Section: Genetic Studies Of Iganmentioning

confidence: 99%

The Genetics of IgA Nephropathy: An Overview from China

Zhu

Zhang²

2015

Kidney Dis

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Background: IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide. Highly variable data for disease prevalence and reports of familial clustering suggest the involvement of genetic factors in IgAN. As China is an area with a high prevalence of IgAN, Chinese scholars have made a considerable effort to reveal the underlying genetic architecture of IgAN. Summary: In this review, we summarize recent achievements in the genetic studies of IgAN, focusing mainly on studies undertaken in China. Early association studies followed a population-based design and focused on a single variant or single gene. Subsequently, family-based designs and genetic interactions applied by Chinese scholars revealed an association of variants in MEGSIN and glycosyltransferase genes with IgAN. Recently, genome-wide association studies (GWAS) have been used to identify multiple susceptibility loci for IgAN, and they have, for the most part, been validated in Chinese populations. Key Messages: More efforts should be made to explore the underlying genetic mechanisms of GWAS-identified variants. In future studies in IgAN, the application of a systems genetics approach would be helpful and productive. Facts from East and West: The reported prevalence of IgAN is higher in Asia than in Europe and North America. However, differences in use of biopsy for the diagnosis of IgAN should be taken into account in analyzing data from both East and West. In Europe, IgAN affects men more frequently than women; this is not the case in Asia. Familial IgAN has been more frequently reported in Europe than in Asia. Within Europe, familial IgAN is more evident in southern than in northern populations. Changes in the pattern of serum IgA1 O-glycosylation is a common finding in IgAN patients in the East and West. SNPs within the gene coding for the enzyme C1GALT1 have been reported in Chinese and European patients. However, there is no evidence for a role of gene polymorphism of the C1GALT1 chaperone cosmc in Europeans. Genetic variants in the HLA gene family have been observed in populations from the East and West. Associations between IgAN and variants of the TAP1/PSMB and DEFA genes were observed in Asian but not in Western patients. Association with the angiotensin-converting enzyme gene was seen only in Asian patients.

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Association of angiotensinogen gene M235T polymorphism with the risk of IgA nephropathy: a meta-analysis

Cited by 9 publications

References 36 publications

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis

Association of AGT M235T gene polymorphism with HSP/HSPN risk

The Genetics of IgA Nephropathy: An Overview from China

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