Association of ankyrin repeats &amp; kinase domain containing 1 (ANKK1) gene polymorphism with co-morbid alcohol &amp; nicotine dependence

Quraishi, Rizwana; Jain, Raka; Mishra, Ashwani Kumar; Ambekar, Atul

doi:10.4103/ijmr.ijmr_458_14

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Higher FTND and HSI scores were observed earlier among nicotine users alone[ 26 ] or with co-dominance of alcohol use. [ 17 23 ] These results build the growing evidence base about genetic vulnerability underlying concurrent alcohol and tobacco dependence.…”

Section: Discussionmentioning

confidence: 56%

“…To test the hypothesis of whether Met allele predicts substance use, binary logistic regression analysis was performed taking each dependent variable (Alcohol and nicotine consumed and FTND and HSI score) one at a time, as per our earlier reports. [ 17 ] The independent variable considered was the presence and absence of Met allele as risk and reference allele, respectively (Met 1 and Val 0). This provided estimates of the odds of risk by adjusting with respect to the duration of use.…”

Section: Methodsmentioning

confidence: 99%

“…Early reports from a similar setting found an association of ankyrin repeats and kinase domain containing 1 gene polymorphism with higher consumption of alcohol and nicotine. [ 17 ] The available literature pointed toward a dearth of information over the influence of COMT gene Val158Met on alcohol and tobacco consumption in the Indian population. This study was planned to investigate the influence of COMT gene polymorphism Val158Met among North Indian Treatment seeking alcohol and nicotine-dependent participants.…”

Section: Introductionmentioning

confidence: 99%

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Influence of catechol-O-methyltransferase enzyme gene polymorphism on alcohol and tobacco consumption in North Indian treatment seeking population

Quraishi

Sharma

Jain

et al. 2021

Indian Journal of Psychiatry

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Background: The co-occurrence of alcohol and tobacco dependence is frequently witnessed in treatment settings. It is a challenge for clinicians to treat such patients due to their powerful biological association. Aim: The study is aimed to assess the relationship of Catechol-O-methyltransferase (COMT) Val158Met polymorphism with substance intake among individuals who are dependent on both alcohol and tobacco. Materials and Methods: A cross-sectional study involving patients coming to the outpatient department was planned. Brief information on their sociodemographic and substance use profile was recorded. Genotyping of COMT Val158Met was carried out using established polymerase chain reaction-restriction fragment length polymorphism method. The COMT genotyping was classified based on the presence or absence of Met allele using the dominant model. Descriptive statistics, Chi-square test, Mann–Whitney test, and Binary logistic regression analysis were performed to analyze the data. Results: The study included 104 alcohol and nicotine co-dependent subjects. More than eighty percent of the participants were educated above secondary level, married, and employed. The allele frequencies of met and Val were found to be 0.23 and 0.77, respectively. Forty percent of the participants reported tobacco-related health problems. The odds of consuming alcohol and nicotine were four times high among Met allele carriers. While the Fagerström test for nicotine dependence and heaviness of smoking index scores were up to four and eight times higher among met allele (odds ratio 4.3 and 8.9, respectively). Conclusion: Patients carrying Met allele are reported to consume higher amounts of alcohol and tobacco and were likely to score high among measures of nicotine dependence. Thus met allele carriers needs additional attention for a successful treatment outcome.

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Section: Discussionmentioning

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of catechol-O-methyltransferase enzyme gene polymorphism on alcohol and tobacco consumption in North Indian treatment seeking population

Quraishi

Sharma

Jain

et al. 2021

Indian Journal of Psychiatry

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“…Taq1A polymorphism was very well studied in world's different populations [3,5,9,15,16] as well as in different Indian regions [17][18][19][20][21][22][23][24][25][26][27]. Various studies reported presence of A1 allele is significantly higher in certain drug of abuse such as alcoholism and other behavioural characteristics as well [28].…”

Section: Resultsmentioning

confidence: 99%

DRD2 TaqI A polymorphism in Eastern Uttar Pradesh population

Chaudhary

Yadav

Kumar

et al. 2019

Preprint

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Dopamine receptor D2 (DRD2) encoded by DRD2 gene, is located on chromosome 11q22-23. Dopamine plays the central role in motivation, cognition, and reward seeking behaviour. Its dysfunction is implicated in numerous neurological and psychiatric disorders including drug abuse, schizophrenia, ADHD etc. The TaqI A polymorphism is localized 9.8 kb downstream from DRD2 gene in exon 8 of protein kinase gene (ANKK1). It is a SNP demonstrated to cause Glutamate to Lysine substitution at 713 amino acid residue in putative binding domain of ANKK1. Due to the central role of dopamine in reward seeking behavior, DRD2 TaqI A loci is a suitable candidate for investigation of molecular basis of addiction.The aim of the present study is to evaluate the frequency of DRD2 TaqI A polymorphism in Eastern Uttar Pradesh population.3ml blood samples were collected from 50 individuals randomly selected from Eastern UP.Written informed consent along with profile detail was taken from each subject prior to blood sample collection. DRD2 TaqI A polymorphism analysis was done by PCR-RFLP method.Genomic DNA was extracted from each collected blood samples and amplified using DRD2 Taq1 region specific primers. PCR amplification produced 310bp long amplicon which was digested with Taq I enzyme for polymorphism analysis. In case of A2 allele, Taq1 enzyme cleaved 310bp long fragment into two fragments of 180bp and 130bp. In case of A1 allele, a C to T substitution demolished the restriction site of Taq1, so amplicon of A1 allele remained uncut. In total 50 sample analyzed in present study, A2/A2, A2/A1 and A1/A1 genotype were found in 12, 32 and 06 samples respectively. The genotypic frequencies of mutant homozygous (A1/A1) is 0.12, heterozygous (A2/A1) is 0.64 and normal homozygous (A2/A2) is 0.24. The allelic frequency of A1 is 0.44 and of A2 is 0.56. In conclusion, the results of present study suggests that in TaqI A polymorphism of DRD2 gene, the frequency of allele A2 is higher than that of A1 allele in population of Eastern Uttar Pradesh.

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“…[ 42 ] Quraishi et al . [ 43 ] examined the association between Ankyrin repeats and kinase domain containing 1 (ANKK1) gene polymorphism and alcohol use-related variables. AUD patients with an A1 genotype were 2.5 times more likely to report higher alcohol consumption.…”

Section: Factors Associated With Alcohol Usementioning

confidence: 99%

Alcohol use disorder research in India: An update

Narasimha,

Mukherjee,

Arya

et al. 2024

Indian Journal of Psychiatry

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Background: Despite alcohol use being a risk factor for numerous health-related conditions and alcohol use disorder (AUD) recognized as a disease, there was limited research in India until 2010. This narrative review aims to evaluate AUD-related research in India from 2010 to July 2023. Methods: A PubMed search used key terms for AUD in India after 2010. Indian and international journals with regional significance that publish alcohol-related research were searched by each author individually. These were then collated, and duplicates were removed. In addition, we also conducted a gray literature search on focused areas related to AUD. Results: The alcohol-related research in India after 2010 focused on diverse areas associated with alcohol use. Some areas of research have received more attention than others. Two major epidemiological surveys conducted in the past decade reveal that around 5% have a problematic alcohol use pattern. Factors associated with alcohol use, like genetic, neurobiological, psychological, and sociocultural, were studied. The studies focused on the clinical profile of AUD, including their correlates, such as craving, withdrawal, alcohol-related harm, and comorbid psychiatric and medical illnesses. During this period, minimal research was conducted to understand AUD’s laboratory biomarkers, course, and prognosis. While there was a focus on generating evidence for different psychological interventions for alcohol dependence in management-related research, pharmacological studies centered on anticraving agents like baclofen. Research on noninvasive brain stimulation, such as rTMS, has shown preliminary usefulness in treating alcohol dependence. Very little research has been conducted regarding alcohol policy. Conclusion: In the past decade, Indian research on alcohol has focused on diverse areas. Epidemiological and psychological management-related research received maximum attention. Considering the magnitude of the alcohol-related burden, it is essential to prioritize research to other less studied areas like pharmacological management of alcohol dependence and alcohol policy.

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Association of ankyrin repeats & kinase domain containing 1 (ANKK1) gene polymorphism with co-morbid alcohol & nicotine dependence

Cited by 6 publications

References 26 publications

Influence of catechol-O-methyltransferase enzyme gene polymorphism on alcohol and tobacco consumption in North Indian treatment seeking population

Influence of catechol-O-methyltransferase enzyme gene polymorphism on alcohol and tobacco consumption in North Indian treatment seeking population

DRD2 TaqI A polymorphism in Eastern Uttar Pradesh population

Alcohol use disorder research in India: An update

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