Association of anti-Ro52, anti-Ro60 and anti-La antibodies with diagnostic, clinical and laboratory features in a referral hospital in Jerez, Spain

Almagro, Raúl Menor; Roger, Aurora Jurado; Gutiérrez, Francisco Javier Rodríguez; Díaz, Rocío Solís; Cardiel, Mario H.; Maestrojuan, José Javier Salaberri

doi:10.1016/j.reumae.2015.10.013

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…On comparing the frequency of anti-dsDNA, anti-nucleosome, anti-histone, anti-Ro60, and anti-Ro52 autoantibodies between patients with nephritis and those without nephritis, we found a very high significant difference regarding, anti-dsDNA, anti-nucleosome, and anti-histones and this agrees with Sui et al and Yang et al [24,25], and a high significant difference regarding anti-Ro60 and anti-Ro52, this in agreement with Kerboua et al and Mahmoudi et al [26,27]. It is reported that anti-Ro60 is detected in SLE and Sjogrenʼs syndrome with a much higher percentage in cutaneous lupus erythematosus while anti-Ro52 is associated with more diseases as interstitial lung disease, congenital heart block, neoplastic diseases and infections [28][29][30]. Our findings confirmed that increased number of autoantibody positivity was accompanied with increased mean rank of the SLEDAI and this was clear when we compared the mean rank of patients who are positive for only one autoantibody with that of patients who are negative for the five antibodies and also when we compared all other groups.…”

Section: Discussionsupporting

confidence: 85%

Autoantibodies spectrum in lupus nephritis in a cohort of Egyptian patients: relation to disease activity and prognostic value

Elsayed

Mohafez

2020

Egypt Rheumatol Rehabil

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Background Specific autoantibodies are considered as an important marker in autoimmune rheumatic diseases and are of great value for the diagnosis and prognosis of systemic lupus erythematosus (SLE) patients. A total of eighteen autoantibodies were analyzed for their positivity in SLE patients and we evaluated the clinical relevance of the five most frequent autoantibodies: anti-dsDNA, anti-nucleosome, anti-histone, anti-Ro60, and anti-Ro52 on disease activity and renal affection in SLE Egyptian patients. Results Immunological profile and correlation of the five autoantibodies with disease activity and histopathological pattern of renal involvement were analyzed for 190 SLE patients. Lupus nephritis (LN) patients showed much worse constitutional and mucocutaneous manifestations than patients without nephritis. Autoantibody profile showed a significant increased frequency of anti-dsDNA, anti-nucleosome, anti-histone, anti-Ro-60, and anti-Ro52 antibodies in LN patients. The impact of the co-positivity of the autoantibodies on the renal function was obvious. Moreover, the disease activity increased by the increased frequency of autoantibodies positivity in LN patients. ROC curve analysis showed that anti-nucleosome had the highest sensitivity; 93% followed by anti-dsDNA 83.3% then anti-histone 73.8%, but anti-Ro60 and anti-Ro52 showed a humble sensitivity. Furthermore, the highest frequency of positivity for the five autoantibodies was found in class-III and class-IV LN patients. Conclusion Detection of anti-dsDNA, anti-nucleosome, anti-histone, and anti-Ro60 in SLE patients may be important for predicting disease progression and kidney affection. Moreover, anti-nucleosome and anti-dsDNA show high sensitivity and specificity for lupus nephritis, thus patients with four to five positive autoantibody panels should be kept under close monitoring as they may warrant considering aggressive therapy to control their disease and prevent renal damage.

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Section: Discussionsupporting

confidence: 85%

Autoantibodies spectrum in lupus nephritis in a cohort of Egyptian patients: relation to disease activity and prognostic value

Elsayed

Mohafez

2020

Egypt Rheumatol Rehabil

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“…For example, a frequently asked question is whether there is an ICAP AC pattern for monospecific anti-Ro52. The consensus is that anti-Ro52 antibodies do not produce a distinctive staining pattern on commercially prepared HEp-2 cells, which is consistent with published studies (13,14). Anti-Ro52 autoantibodies also do not show reactivity in double immunodiffusion or classical positive sample shows any reactivity in HEp-2 IFA, it probably contains additional autoantibodies against antigens other than anti-Ro52.…”

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confidence: 86%

The International Consensus on ANA Patterns (ICAP) in 2021—The 6th Workshop and Current Perspectives

Chan

Mühlen

Fritzler

et al. 2022

The Journal of Applied Laboratory Medicine

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The establishment of the International Consensus on ANA Patterns (ICAP) in 2014–2015 was welcomed by members of the medical community as a significant improvement in guiding harmonization of ANA test interpretation and reporting. In the subsequent years, several itinerant meetings and continuous interaction with the community contributed to disseminate the ICAP harmonization on the immunofluorescence patterns observed in the indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) and to promote progressive improvement in the classification of HEp-2 IFA patterns. The 6th ICAP Workshop was held in person on September 6, 2021 as a satellite meeting of the 15th Dresden Symposium on Autoantibodies. This article summarizes the major discussions at the meeting as well as outlining the current plans for the ICAP committee.

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“…The high positive rates of Ro-52 and SSA in a variety of disease were consistent with other studies. 18,19 In our study, native SSA antigen was purified by affinity chromatography from bovine spleen and thymus. For Ro-52, the corresponding human cDNA has been expressed with the baculovirus system in insect cells.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of trait antinuclear antibodies and multiple immunoglobulin production in autoimmune diseases

Wan

Zhu

et al. 2017

Clinical Laboratory Analysis

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Association of anti-Ro52, anti-Ro60 and anti-La antibodies with diagnostic, clinical and laboratory features in a referral hospital in Jerez, Spain

Cited by 5 publications

References 27 publications

Autoantibodies spectrum in lupus nephritis in a cohort of Egyptian patients: relation to disease activity and prognostic value

Autoantibodies spectrum in lupus nephritis in a cohort of Egyptian patients: relation to disease activity and prognostic value

The International Consensus on ANA Patterns (ICAP) in 2021—The 6th Workshop and Current Perspectives

Diagnostic value of trait antinuclear antibodies and multiple immunoglobulin production in autoimmune diseases

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