Association of antiphospholipid antibodies with retinalvascular disease in systemic lupus erythematosus

Montehermoso, Alfredo; Cervera, Ricard; Font, Josep; Ramos-Casals, Manuel; Garcı́a-Carrasco, Mario; Formiga, Francesç; Callejas, José Luis; Jorfán, Marisa; Griñó, Maria C.; Ingelmo, M

doi:10.1016/s0049-0172(99)80017-1

Cited by 91 publications

(63 citation statements)

References 17 publications

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“…Retinopathy including arterial and venous occlusion, cottonwool spots, optic disk edema and hemorrhages reported to be higher among SLE patients at the presence of aPL compared with SLE patients who has negative antibody against aPL [104]. Similar ocular and neuro-ophthalmic manifestations also reported in both primary and secondary anti-phospholipid syndrome (APS) [8].…”

Section: Role Of Antiphospholipid Syndromementioning

confidence: 80%

Ocular Manifestations in Systemic Lupus Erythematosus

Maghsoudlou¹

2015

Rheumatology (Sunnyvale)

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Systemic lupus erythematosus (SLE) is an autoimmune disease manifest with multiple organ system involvement. Even though the eye is not part of the diagnostic criteria, once it gets affected, it will alter patients' quality of life. The purpose of this review is to point out the significance of ocular manifestations in SLE and to emphasize the importance of possible blinding complications such as peripheral ulcerative keratitis, scleritis, and SLE retinopathy/ choroidopathy. The condition can be even worse when SLE is accompanied with antiphospholipid syndrome. In addition to the disease itself, several treatment agents that are used in SLE are responsible for vision threatening conditions; thus they have to be given with caution because of potential side effects, including cataract, glaucoma, and chloroquine maculopathy.

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Section: Role Of Antiphospholipid Syndromementioning

confidence: 80%

Ocular Manifestations in Systemic Lupus Erythematosus

Maghsoudlou¹

2015

Rheumatology (Sunnyvale)

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“…There have been fewer than 50 patients previously reported in the literature (4)(5)(6)(7)(8) . Approximately 35% of adults with SLE have clinical evidence of nephritis at the time of diagnosis, with an estimated total of 50-60% developing nephritis during the first 10 years of disease (9)(10)(11)(12) .…”

Section: Doi: Http://dxdoiorg/103329/bjmedv29i135406mentioning

confidence: 99%

“…In 50% of SLE patients with this type of vaso-occlusive retinopathy, visual acuity was less than 6/20 [6][7][8] . In our patient visual acuity of both eye improved to finger counting.…”

Section: Case Reportmentioning

confidence: 99%

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Vaso-occlusive retinopathy and stage IV Lupus Nephritis; Primary manifestation of a 30 year old female

Saiful¹,

Elahi²,

Mostafi³

et al. 2018

Bangla J Med

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The diagnosis of systemic lupus erythematosus (SLE) depends on clinical evidence of renal, rheumatologic, cutaneous, and neurologic involvement, supported by serological markers. Ocular involvement is not included in diagnostic criteria of SLE. Vaso-occlusive retinopathy, as the primary manifestation of systemic lupus erythematosus (SLE), is relatively rare. We report a 30-year-old female, who suddenly suffered bilateral visual loss. Fundus examination revealed bilateral occlusive retinal vasculitis. She fulfilled the American College of Rheumatology criteria for diagnosing SLE; she had arthralgia, photosensitivity, positive ANA, high titre of anti-dsDNA, and proteinuria. A renal biopsy showed stage IV lupus nephritis. Treatment was initiated with pulse steroid and immunosuppressant. Best corrected visual acuity of both eye improved to finger counting after treatment. This case demonstrates that in patients with severe vaso-occlusive retinopathy, a generalized immunological disorder, like SLE, should be suspected.Bangladesh J Medicine Jan 2018; 29(1) : 36-40

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“…[8][9][10][11] Retinal vascular changes correlate with the degree of systemic disease activity. Stafford-Brady et al reported that 88% of patients with retinopathy had active systemic disease and 73% had central nervous system involvement.…”

Section: Incidental Retinal Vascular Findings In Slementioning

confidence: 99%

Incidental retinal vascular occlusions on hydroxychloroquine screening in patients with systemic lupus erythematosus

Bajwa¹,

Khurana²,

Kimpel³

et al. 2015

OTT

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Objective:The proportion of patients with systemic lupus erythematosus (SLE) who manifest retinal involvement increases many fold in patients with active systemic disease. The objective of this report is to stress upon the significance of comprehensive ophthalmic assessment of all SLE patients to prevent and manage blinding ocular manifestations of the disease. Methods: Retrospective case review. Results: Incidental retinal vascular complications seen in patients undergoing baseline hydroxychloroquine screening. Conclusion:The purpose of comprehensive ophthalmic screening in SLE patients is twofold. It will aid in the diagnosis and treatment of blinding ocular complications of the disease and monitor hydroxychloroquine macular toxicity.

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Association of antiphospholipid antibodies with retinalvascular disease in systemic lupus erythematosus

Cited by 91 publications

References 17 publications

Ocular Manifestations in Systemic Lupus Erythematosus

Ocular Manifestations in Systemic Lupus Erythematosus

Vaso-occlusive retinopathy and stage IV Lupus Nephritis; Primary manifestation of a 30 year old female

Incidental retinal vascular occlusions on hydroxychloroquine screening in patients with systemic lupus erythematosus

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