Association of aortic wall thickness on contrast-enhanced chest CT with major cerebro-cardiac events

Tresoldi, Silvia; Leo, Giovanni Di; Zoffoli, Elena; Munari, Alice; Primolevo, Alessandra; Cornalba, Gianpaolo; Sardanelli, Francesco

doi:10.1177/0284185113513978

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…In particular, thoracic aortic atherosclerosis is closely related to the degree of coronary artery disease (CAD). 2 With advancing polyvascular atherosclerosis, the accumulation of atherosclerosis risk factors, previous atherothrombotic events and more severe CAD are observed. 3 There are several terms that characterize vascular wall properties: distensibility, elasticity, compliance and stiffness.…”

Section: Introductionmentioning

confidence: 99%

Can we predict the presence of coronary lesions from blood pressure measurement? A new clinical method

et al. 2015

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The roles of arterial function and structure in cardiovascular physiology have expanded with the development of a variety of parameters that evaluate arterial stiffness. Markers of arterial stiffness have been correlated with cardiovascular outcomes. We aimed to find a simple, clinical, noninvasive method to predict atherosclerosis that leads to the development of coronary artery disease (CAD). We aimed to find a simple, clinical, noninvasive method to predict atherosclerosis that leads to the development of CAD. We included 100 cases that underwent coronary angiography in our center owing to different indications. The blood pressure in all cases was measured by two different observers. The oscillatory systolic blood pressure (OSBP) was defined as the point at which the mercury began to oscillate to a minimum level of 1 mm Hg. The auscultatory systolic blood pressure (AUSBP) was defined as the first Korotkoff sound. The difference between OSBP and AUSBP was calculated and called the oscillatory gap (OG). The correlation between the OG and the presence of coronary lesion in coronary angiography was statistically calculated. The study populations had a mean age of 57.3±9 years. The mean±s.d. OG was 14.44±10.44. There was a highly significantly positive correlation between the OG and the presence of coronary artery lesions (r=0.399 and P-value <0.000). There was also a significantly positive correlation between the presence of hypertension and the OG (r=0.376 and P-value <0.000). The difference between OSBP and AUSBP could be used as a simple method to detect atherosclerotic arterial changes. This method could indicate the degree of arterial stiffness. There was a significantly positive correlation between this new indicator of arterial stiffness and the presence of CAD. Any patient with a wide gap between OSBP and AUSBP should be treated early with antihypertensive drugs and statins before the development of CAD.

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Section: Introductionmentioning

confidence: 99%

Can we predict the presence of coronary lesions from blood pressure measurement? A new clinical method

et al. 2015

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“…Particularly, thoracic aortic atherosclerosis is responsible for most myocardial infarctions, strokes and aneurisms (4,15,18,19,20).…”

Section: Discussionmentioning

confidence: 99%

“…Atherosclerosis in the thoracic aorta is closely related to the degree of coronary and carotid disease (4). The most common risk factors that may inhibit or accelerate atherosclerosis are hyperlipidemia, smoking, hypertension and diabetes (5).…”

Section: Ivyspringmentioning

confidence: 99%

A macroscopic analysis of the epidemiology of thoracic aorta atherosclerosis: An autopsy study

Gogakos¹,

Chatzinikolaou²,

Κoletsa³

et al. 2017

J. Biomed

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Background: Atherosclerosis is the most important cardiovascular disease across the globe with a large proportion of associated morbidity and mortality. The aim of this study is to detect the presence of atherosclerosis-like lesions in the three segments of the thoracic aorta (ascending aorta, aortic arch and descending aorta) of 50 unselected adult cadavers of all ages. Methods: An autopsy analysis was performed using 50 unselected adult cadavers (37 male, 13 female -mean age 64.2 years; age range 19-90 years). Macroscopic dissection of the three segments of the thoracic aorta was performed and the presence of atherosclerosis-like lesions was evaluated according to the subjects' demographic and clinical characteristics. Results: Atherosclerotic lesions in at least one of the three aortic segments were identified in 82% of cadavers, 83.78% of male and 76.92% of female. Of 50 subjects, 30% had an atherosclerotic lesion in the ascending aorta, 48% in the aortic arch and 44% in the descending aorta. No aneurysmal changes were detected. Smoking, hypertension, diabetes, hypercholesterolemia, obesity and coronary disease were the risk factors correlated most with the presence of atherosclerosis. Conclusions: Atherosclerosis-like lesions in the thoracic aorta are prevalent in adults of all ages. Obesity is a major risk factor regarding the development of atheromas. This cadaveric study comes to underline the necessity of further similar studies in order to evaluate the presence of atherosclerosis in the thoracic aorta, and also helps to assess the risk of major cardiovascular events in the general population.

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“…Vessel wall diameter, transverse area, and length of the diseased vessel are structural characteristics that have been associated with further vascular events. 71,72 Change in the vascular transverse area is associated with vascular wall remodeling in the setting of atherosclerosis and is commonly seen as vascular enlargement. 66,73,74 This change is associated with unstable plaques and higher incidence of cardiovascular events.…”

Section: Methods Using Vessel Wall Structure In Addition To Fdg Uptakmentioning

confidence: 99%

Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification

Gholami

Salavati

Houshmand

et al. 2015

Journal of Nuclear Cardiology

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There is growing evidence showing the importance of fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of vessel wall inflammation and atherosclerosis. Although this imaging modality has been increasingly used, there are various methods for image acquisition and evaluating FDG uptake activity in the vessel walls and atherosclerotic lesions, including qualitative visual scaling, semi-quantitative, and quantitative evaluations. Using each of these image acquisition protocols and measurement methods may result in different findings. In this review, we are going to describe the various image acquisition methods and common measurement strategies reflected in the literature and discuss their advantages and flaws.

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Association of aortic wall thickness on contrast-enhanced chest CT with major cerebro-cardiac events

Abstract: Patients with increased thoracic AWTmax on chest MDCT could be considered at risk for CCV disease.

Cited by 9 publications

References 15 publications

Can we predict the presence of coronary lesions from blood pressure measurement? A new clinical method

Can we predict the presence of coronary lesions from blood pressure measurement? A new clinical method

A macroscopic analysis of the epidemiology of thoracic aorta atherosclerosis: An autopsy study

Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification

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