Association of Apathy With Risk of Incident Dementia

Dalen, Jan Willem van; Wanrooij, Lennard L. van; Charante, Eric P. Moll van; Brayne, Carol; Gool, Willem A. van; Richard, Edo

doi:10.1001/jamapsychiatry.2018.1877

Cited by 104 publications

(82 citation statements)

References 70 publications

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“…This question is designed to capture anhedonia, and the cross loading observed could reflect different interpretation of this question among respondents because anhedonia is a symptom of depression as well as reflecting apathy, specifically emotional apathy. There is a growing recognition of the importance of the distinction between apathy and depression as markers of dementia (Ismail et al, 2018a;Palmer et al, 2010;Sherman et al, 2018;van Dalen et al, 2018), so it is interesting that there is some loading across both affective and motivation/drive items of the MBI-C. The suggestion here is that, at least in the cognitively normal population, some refinement to the wording of this particular question may be necessary to capture this distinction in the MBI-C. Alternatively, these data raise questions as to whether or not psychiatric constructs developed for a general population, often reflecting neurodevelopmental disorders, accurately represent the emergence of neuropsychiatric symptoms in older adults.…”

Section: Discussionmentioning

confidence: 99%

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

Creese

Griffiths

Brooker

et al. 2019

Int. Psychogeriatr.

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ABSTRACTObjectives:In this large population study, we set out to examine the profile of mild behavioral impairment (MBI) by using the Mild Behavioral Impairment Checklist (MBI-C) and to explore its factor structure when employed as a self-reported and informant-rated tool.Design:This was a population-based cohort study.Setting:Participants were recruited from the Platform for Research Online to Investigate Genetics and Cognition in Aging study (https://www.protect-exeter.org.uk).Participants:A total of 5,742 participant-informant dyads participated in the study.Measurements:Both participants and informants completed the MBI-C. The factor structure of the MBI-C was evaluated by exploratory factor analysis.Results:The most common MBI-C items, as rated by self-reported and informants, related to affective dysregulation (mood/anxiety symptoms), being present in 34% and 38% of the sample, respectively. The least common items were those relating to abnormal thoughts and perception (psychotic symptoms) (present in 3% and 6% of the sample, respectively). Only weak correlations were observed between self-reported and informant-reported MBI-C responses. Exploratory factor analysis for both sets of respondent answers indicated that a five-factor solution for the MBI-C was appropriate, reflecting the hypothesized structure of the MBI-C.Conclusion:This is the largest and most detailed report on the frequency of MBI symptoms in a nondementia sample. The full spectrum of MBI symptoms was present in our sample, whether rated by self-reported or informant report. However, we show that the MBI-C performs differently in self-reported versus informant-reported situations, which may have important implications for the use of the questionnaire in clinic and research.

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Section: Discussionmentioning

confidence: 99%

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

Creese

Griffiths

Brooker

et al. 2019

Int. Psychogeriatr.

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“…Patients with MCI with apathy have an increased risk of dementia, independent of depression. A systematic review found that apathy was associated with an approximately two-fold increased risk of dementia in memory clinic patients (van Dalen et al, 2018). Robert et al (2006) found that MCI patients with apathy develop AD more than MCI patients without apathy.…”

Section: Apathy: a More Important Indicatormentioning

confidence: 99%

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

2020

Front. Aging Neurosci.

203

157

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Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study's objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy.Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy.Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and Implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.

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“…8 The presence of apathy significantly affects the patient's and caregivers' quality of life. 11,12 Apathy can be found also in healthy elderly people with subjective cognitive decline (SCD), a condition characterized by self-reported cognitive problems in absence of objective cognitive dysfunction, 13 and in a minor percentage of healthy young adults. 11,12 Apathy can be found also in healthy elderly people with subjective cognitive decline (SCD), a condition characterized by self-reported cognitive problems in absence of objective cognitive dysfunction, 13 and in a minor percentage of healthy young adults.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 In people with neurodegenerative disorders, apathy can appear at the early stages of the disease progression, and the presence of apathy can be associated to a faster cognitive and functional decline. 11,12 Apathy can be found also in healthy elderly people with subjective cognitive decline (SCD), a condition characterized by self-reported cognitive problems in absence of objective cognitive dysfunction, 13 and in a minor percentage of healthy young adults. 14 On the basis of the classical apathy definition, 1,15 Robert et al 16 in 2009 proposed a set of diagnostic criteria for apathy (DCA) that patients with brain disorders should meet to receive an apathy diagnosis.…”

Section: Introductionmentioning

confidence: 99%

A survey on the prevalence of apathy in elderly people referred to specialized memory centers

Manera

Fabre

Stella

et al. 2019

Int J Geriat Psychiatry

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Background Apathy is a pervasive neuropsychiatric syndrome in people with neurocognitive and psychiatric disorders. The diagnostic criteria for apathy (DCA) have been revised in 2018. Objectives Employing the 2018 DCA, in the present study, we investigated in groups of elderly subjects suffering from different neuropsychiatric disorders (a) the apathy prevalence; (b) the most commonly affected apathy dimensions (behavior/cognition, emotion, and social interaction); (c) the sensitivity and specificity of those dimensions for apathy diagnosis; and (d) the concurrent validity of 2018 DCA compared with the 2009 DCA. Methods This multicenter survey included 166 subjects. Each center checked the presence of apathy in subjects belonging to the following DSM‐5 diagnoses: mild neurocognitive disorders (mild NCDs); major NCDs; affective disorders (Aff D); and subjective cognitive decline (SCD). Results The frequency of apathy varied significantly based on the diagnostic groups (0% of subjects with apathy in the SCD group; 25% in the mild NCD group; 77% in the major NCD group; and 57% in the Aff. D group). All subjects with apathy fulfilled the criteria for the behavior/cognition dimension, 73.1% fulfilled the criteria for the emotion dimension, and 97.4% fulfilled the criteria for the social interaction dimension. Behavior/cognition showed the highest sensitivity, the copresence of emotion and social interaction the highest specificity. The concordance between the 2009 and the 2018 DCA indicated an almost perfect agreement. Conclusions These results are consistent with previous reports and confirm that the social interaction dimension added to the 2018 DCA is present in most of subjects with apathy referred to specialized memory centers.

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Association of Apathy With Risk of Incident Dementia

Cited by 104 publications

References 70 publications

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

A survey on the prevalence of apathy in elderly people referred to specialized memory centers

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