Association of APOE Gene Polymorphisms with Cerebral Infarction in the Chinese Population

Zhong, Zhixiong; Wu, Heming; Yang, Min; Yang, Yuxian; Luo, Weixiong; Wu, Yanli; Wu, Hesen; Zhong, Ming; Zhao, Pingsen

doi:10.12659/msm.905979

Cited by 12 publications

(12 citation statements)

References 24 publications

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“…In the Chinese population, the predominant genotype is E3/ E3 in the Chinese population, whereas the most common allele is E3, followed by E2/E3, E3/E4, E2/E4, E4/E4, and E2/E2. [23][24][25] Our research also confirmed that E3/E3 and E3 were dominant. However, in this research, the E3/E4 genotype follows the E3/E3 genotype in WML group and brain atrophy group, respectively, but the E2/E2 genotype follows the E2/E3 genotype in the co-occurrence of WML and brain atrophy disease group.…”

Section: Discussionsupporting

confidence: 79%

Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy

Niu

Zhang

Dong

et al. 2020

Psychiatry Investig

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Objective Apolipoprotein E (ApoE) is mainly synthesized in the liver. So far, it is unknown the relationship among APOE gene polymorphisms and WML, brain atrophy. Therefore, the aim of the study was to assess the associations of APOE gene polymorphisms in patients with WML and brain atrophy.Methods A total of 58 patients with WML, 128 patients with brain atrophy, 112 patients with co-occurrence of WML and brain atrophy and 95 healthy elderly volunteers were recruited from Renmin Hospital of WuHan University.Results Allele E3 was the most common allele. The alleles E2 had significantly higher levels of ApoB and lower age in WML group. The alleles E2 was associated with the lower level of ApoB, LDL-Ch, TCh, and sdLDL in co-occurrence group. The E3/E3 genotype has higher level of sdLDL, but lower age and female frequency in WML. The E3/E4 genotype had higher level of TG, but lower age in WML. Gender, Age, E2, Hyperhomocysteinemia and UA were also significantly associated with disease progression.Conclusion This study found that clinical data, lipids and metabolic complications were closely related to ApoE genotypes and alleles, and also disease progression and type.

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Section: Discussionsupporting

confidence: 79%

Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy

Niu

Zhang

Dong

et al. 2020

Psychiatry Investig

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“…The risk of CI may vary according to the presence of various genetic and environmental factors. In addition, the relationship between the functional variation of multiple gene in different ethnic groups and CI risk has been studied, including the polymorphisms of interleukin-6 gene [2], βfibrinogen gene [3], PON1 hypermethylation and PON3 hypomethylation [4], 5-lipoxygenase-activating protein gene association (ALOX5AP) [5], the cytochrome P450 1A1 (CYP1A1) gene [6], the human scavenger receptor class B type I (SR-BI) gene [7], genes associated with lipid metabolism [8,9], and others [10]. In general, it is important for both risk prediction and prevention of CI by identifying genetic risk.…”

Section: Introductionmentioning

confidence: 99%

The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population

Huang

et al. 2020

Lipids Health Dis

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Background: Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) regulate lipid metabolism. However, the relationship between genetic polymorphisms of APOE and SLCO1B1 and cerebral infarction (CI) remains unclear. Methods: A total of 938 CI patients and 1028 control participants were included in the study. The rs429358 and rs7412 single nucleotide polymorphisms (SNPs) in the APOE gene and rs2306283 and rs4149056 SNPs in the SLCO1B1 gene were analyzed by fluorescence polymerase chain reaction (PCR).

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“…Studies have suggested that ApoE E4 allele is an independent risk factor for T2DM and coronary heart disease [12], but the correlation between ApoE and cerebral infarction is controversial. Some studies have pointed out that ApoE E4 allele is the genetic marker of cerebral infarction [13,14], and other studies have suggested that ApoE E3/E3 and E3/E4 genotypes have protective effects on cerebral infarction in Chinese males rather than females [15].…”

Section: Discussionmentioning

confidence: 99%

Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

Kong¹,

Gao²,

Li³

et al. 2020

Preprint

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Objective To analyze and study the relationship between ApoE gene polymorphism and cardio-cerebrovascular complications in type 2 diabetes mellitus(T2DM) in the Chinese Population. Methods From January 2018 to January 2019, 1140 patients with type 2 diabetes admitted to the Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University were selected as the case group, including 590 patients with coronary heart disease(CHD) and 550 patients with cerebral infarction(CI), and 1198 patients with type 2 diabetes without complications during the same period were selected as the control group. General baseline data of the two groups were collected, such as gender, age, course of disease, lipid profile, HbA1C, BMI, blood pressure, carotid plaque and complications. ApoE genotypes were identified in all participants who participated in the study. Results This study showed that the ApoE genotypes in both the case group and the control group had the highest frequency of E3/E3. The E3/E4 genotype frequency and E4 allele frequency in the case group were higher than those in the control group (P < 0.05). In the case group, the frequency of E2/E3 and E3/E4 genotypes of CI group was lower than that of CHD group, while the frequency of E3/E3 genotype was higher than that of CHD group. TC and LDL-c levels were significantly increased in patients with ApoE E3/E4 genotype(P < 0.05). ApoE genotype E3/E4 was more associated with carotid plaque than E2/E3. ApoE genotype and ApoE allele were positively correlated with TC and LDL-c levels (P < 0.05).Logistic regression results show that ApoE gene polymorphism is associated with cardio-cerebrovascular complications in T2DM patients. ApoE E3/E4 genotype and allele E4 may be risk factors for T2DM patients with cardio-cerebrovascular complications. Conclusion ApoE E3/E4 genotypes and T2DM patients carrying E4 allele have a higher risk of cardio-cerebrovascular complications than other genotypes. E4 allele may be a risk factor for cardio-cerebrovascular complications in T2DM patients, and its mechanism may be related to the effect of ApoE gene on lipid metabolism.

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Association of APOE Gene Polymorphisms with Cerebral Infarction in the Chinese Population

Cited by 12 publications

References 24 publications

Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy

Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy

The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population

Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

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