Association of APOL1 Risk Genotype and Air Pollution for Kidney Disease

Paranjpe, Ishan; Chaudhary, Kumardeep; Paranjpe, Manish; O’Hagan, Ross; Manna, Sayan; Jaladanki, Suraj; Kapoor, Arjun; Horowitz, Carol R.; DeFelice, Nicholas; Cooper, Richard S.; Glicksberg, Benjamin S.; Böttinger, Erwin P.; Just, Allan C.; Nadkarni, Girish N.

doi:10.2215/cjn.11921019

Cited by 18 publications

(19 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40,59 Air pollution, fine particulate matter <2.5 mm, might also be an environmental trigger for APOL1-associated nephropathy. 60 Fine particulate matter <2.5 mm and APOL1 were independently associated with nephropathy in individuals with recent African ancestry in New York. However, the effect of fine particulate matter <2.5 mm was stronger in individuals with an APOL1 HR genotype.…”

Section: Biomarkers For Predicting Kidney Diseasementioning

confidence: 94%

APOL1 at 10 years: progress and next steps

Freedman

Kopp

Sampson

et al. 2021

Kidney International

View full text Add to dashboard Cite

Section: Biomarkers For Predicting Kidney Diseasementioning

confidence: 94%

APOL1 at 10 years: progress and next steps

Freedman

Kopp

Sampson

et al. 2021

Kidney International

View full text Add to dashboard Cite

“…Two of the studies found a RR above 1.00 except for one study with a non-significant association. 24 The difference in the risk of APOL1 genetic risk variants with baseline kidney function status was not significant (P=0.8414). The diagnostic criteria for CKD/ESRD incidence varied widely in the included studies ( Supplemental Table 1 ).…”

Section: Resultsmentioning

confidence: 91%

“…Figure 1 summarizes the results of subgroup analyses stratified by the incidence of CKD, ESRD, and CKD to ESRD, respectively. Five studies 14 , 24–27 reported data for the association between APOL1 genotype and the risk of CKD. All of the studies reported a positive association (ie, HR>1.00) between two risk alleles incident CKD compared with zero or one risk allele.…”

Section: Resultsmentioning

confidence: 99%

Association Between APOL1 Genotype and Kidney Diseases and Annual Kidney Function Change: A Systematic Review and Meta-Analysis of the Prospective Studies

Jagannathan

Rajagopalan²,

Hogan

et al. 2021

IJNRD

View full text Add to dashboard Cite

Background Two coding risk variants in the Apo L1 gene ( APOL1 ) underlie most of the excess risk for kidney diseases in recent African ancestry patients. Strength and consistency of the relationship between APOL1 high-risk genotypes and the risk of chronic kidney diseases (CKD) and end-stage renal disease (ESRD) are not uniform. Objective To conduct a systematic review and meta-analysis of prospective studies assessing the association of APOL1 genotypes and the risk of developing CKD, ESRD, and CKD to ESRD in adults. Methods Systematic search of MEDLINE, EMBASE, and Google Scholar was performed for prospective studies assessing the associations between APOL1 genotypes and CKD, ESRD, and progression from CKD to ESRD. Secondary analyses were to evaluate the annual kidney function change by APOL1 gene status. Random effects models were used to estimate pooled risk ratios (RRs) and weighted mean differences for outcomes of interest. Results The search yield 10 prospective during a follow-up period ranging from 4.4 to 25 years. The high-risk APOL1 genotype was associated with the incidence of CKD (RR:1.41[95% CI: 1.14–1.75]), the progression from CKD to ESRD (RR: 1.70[95% CI:1.44; 2.01]) compared with the low-risk APOL1 genotype. There was no appreciable association between high-risk APOL1 genotype with the incidence of ESRD. Furthermore, high-risk APOL1 genotype was associated with a marginal decrement in the annual eGFR decline (−0.55[95% CI: −0.94 to −0.16]) mL/min/1.73m 2 compared with low-risk APOL1 genotype status. Conclusion In summary, African Americans carrying APOL1 high-risk genotypes are at increased risk of developing CKD and ESRD. Given that the APOL1 risk alleles are common among individuals with African ancestry, with ~18% of African Americans carrying high-risk alleles, these findings highlight the potential identification of subgroups of patients who may benefit from APOL1 screening and developing culturally-appropriate interventions.

show abstract

“…Mechanisms of the changing characteristics of INS mechanism remain elusive. We have recently learned how air pollution increases the risk of chronic kidney disease in carriers of the APOL1 high-risk genotype ( 30 ). It remains to be determined whether an interplay between genetic and environmental risk factors contributes to the evolving characteristics of INS.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Response to Corticosteroids Remains a Valid Approach to Initial Management of Children With Idiopathic Nephrotic Syndrome

Narla

Swiatecka‐Urban

2020

Front. Pediatr.

View full text Add to dashboard Cite

Complete remission of idiopathic nephrotic syndrome (INS) in response to corticosteroids has been widely adopted as an indicator of satisfactory long-term outcomes in pediatric patients. The approach was based on the results of studies conducted in the 1960s and 1970s. The studies found that corticosteroid-responsive minimal change disease (MCD) was the most frequent diagnosis in INS patients. In more recent years, studies have reported increased frequency of focal segmental glomerulosclerosis (FSGS) and primary corticosteroid resistance without a corresponding increase of FSGS. It became unclear whether withholding kidney biopsy before treatment with corticosteroids is still the best management practice. We performed a retrospective chart review at the UPMC Children's Hospital of Pittsburgh and identified patients who were referred for evaluation of edema or proteinuria between 2002 and 2014. We identified 114 pediatric patients with INS who were treated initially with a corticosteroid (prednisone or prednisolone) 2 mg/kg (max 60 mg)/day for 4–6 weeks followed by 2 mg/kg (max 60 mg) every other day for 4–6 weeks and had not received a corticosteroid-sparing agent before completing at least 8 weeks of the initial therapy. Corticosteroid resistance in pediatric INS patients was independently associated with the black race, older age at presentation (>8 years), and female sex. The majority of blacks who were resistant to corticosteroids had a tissue diagnosis of MCD. Among the whites who were steroid-resistant, MCD and FSGS were diagnosed in similar proportions of cases. Thus, the tissue diagnosis in could not predict the response to corticosteroids. Nineteen percent of whites with FSGS were steroid-sensitive and none of the blacks with FSGS responded to corticosteroids. These data suggest that the histologic diagnosis of FSGS could not rule out response to corticosteroids, at least, in the white patient population. In summary, our data demonstrate that at this time, the therapeutic response to corticosteroids continues to be a valid approach for the initial evaluation and therapy of children diagnosed with INS at our center. Future studies should evaluate the mechanisms of changing characteristics of pediatric INS. The specific role of patient demographics, ethnicity, as well as genetic and environmental factors could be evaluated by a prospective, multicenter study.

show abstract

Association of APOL1 Risk Genotype and Air Pollution for Kidney Disease

Cited by 18 publications

References 4 publications

APOL1 at 10 years: progress and next steps

APOL1 at 10 years: progress and next steps

Association Between APOL1 Genotype and Kidney Diseases and Annual Kidney Function Change: A Systematic Review and Meta-Analysis of the Prospective Studies

Therapeutic Response to Corticosteroids Remains a Valid Approach to Initial Management of Children With Idiopathic Nephrotic Syndrome

Contact Info

Product

Resources

About