Association of Apolipoprotein E Polymorphisms With Normal Tension Glaucoma in a Chinese Population

Cy, Lam; Bj, Fan; Dy, Wang; Po, Tam; Tham, Clement C.; Leung, Dexter Y.L.; Ds, Ping Fan; Ds, Chiu Lam; Cp, Pang

doi:10.1097/01.ijg.0000212217.19804.a7

Cited by 55 publications

(32 citation statements)

References 39 publications

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“…23 However, the other studies have not confirmed the relationship of -491 A/T APOE polymorphism with POAG. 24,25 The promoter polymorphisms -219 T/G and -427 T/C of the APOE gene were also not associated with glaucoma. 26 There is also evidence that the presence of specific isoforms of the APOE gene may affect glaucoma development.…”

Section: Discussionmentioning

confidence: 91%

Neurodegenerative Genes Polymorphisms of the -491A/TAPOE, the -877T/CAPPand the Risk of Primary Open-angle Glaucoma in the Polish Population

Nowak

Przybyłowska-Sygut

Gacek

et al. 2013

Ophthalmic Genetics

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Section: Discussionmentioning

confidence: 91%

Neurodegenerative Genes Polymorphisms of the -491A/TAPOE, the -877T/CAPPand the Risk of Primary Open-angle Glaucoma in the Polish Population

Nowak

Przybyłowska-Sygut

Gacek

et al. 2013

Ophthalmic Genetics

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“…Five eligible studies were not include in the meta-analysis [13,15,17,21,23]. Meanwhile, two studies contained overlapping data [19,39], and only the largest study [19] should be selected for the analysis. In another study by Wang et al [28], there were many mistakes in the data extraction (see Supplementary Table two in their article).…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis

et al. 2014

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BackgroundEpidemiological studies have evaluated the association between Apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism and glaucoma susceptibility. However, the published data are still inconclusive. The aim of the present study is to evaluate the impact of APOE gene ε2/ε3/ε4 polymorphism on glaucoma risk by using meta-analysis.MethodsA comprehensive literature search of PubMed, EMBASE, Cochrane, Elsevier Science Direct and CNKI databases was conducted to identify relevant articles, with the last report up to January 5, 2014. Pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association by using the fixed or random effect model.ResultsFifteen separate studies including 2,700 cases and 2,365 controls were included in the meta-analysis. We did not detect a significant association between APOE gene ε2/ε3/ε4 polymorphism and glaucoma in overall population (P > 0.0083). In Asians, we detected an association of the ε4ε4 genotype with elevated risk for glaucoma (OR = 5.22, 95% CI = 1.85-14.68, P = 0.002), mainly for primary open angle glaucoma (OR = 4.98, 95% CI = 1.75-14.20, P = 0.003).ConclusionsThe meta-analysis suggests that APOE gene ε4ε4 may be associated with elevated risk for primary open angle glaucoma in Asians. However, more epidemiologic studies based on larger sample size, case–control design and stratified by ethnicity as well as types of glaucoma are suggested to further clarify the relationship between APOE gene ε2/ε3/ε4 polymorphism and genetic predisposition to glaucoma.

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“…Vickers et al [11], Al-Dabbagh et al [12] and Yuan et al [10] reported that the Apo E ε4 gene is associated with elevated risk of POAG or NTG. On the contrary, Lam and his colleagues [13] reported that the Apo E ε4 gene confers a protective effect against NTG. Their findings, however, could not be replicated in other researchers [14], [15], [16], [17], [18], [19], [20].…”

Section: Introductionmentioning

confidence: 95%

Lack of Association of Apolipoprotein E (Apo E) ε2/ε3/ε4 Polymorphisms with Primary Open-Angle Glaucoma: A Meta-Analysis from 1916 Cases and 1756 Controls

et al. 2013

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BackgroundA number of case-control studies were conducted to investigate the association of apolipoprotein E (Apo E) polymorphisms with primary open angle glaucoma (POAG). But the results remain controversial. This meta-analysis aims to comprehensively evaluate the relationship between a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of POAG.MethodA comprehensive literature search for studies published up to April 2013 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were calculated employing random-effects models irrespective of between-study heterogeneity. Publication bias of literatures was evaluated using funnel plots and Egger's test.ResultsA total of 12 studies including 1916 cases and 1756 controls meeting the predefined criteria were involved in this meta-analysis. Overall, the Apo E ε2 allele and ε4 allele were not associated with POAG, compared with those carrying ε3 allele, with ORs of 0.98 (95% CI, 0.79 to 1.23; P = 0.872) and 1.05 (95% CI, 0.78 to 1.41; P = 0.743), respectively. Genotypic analysis also found no significant association between the ε4 carriers (ε3/ε4+ε4/ε4), ε2 carriers (ε2/ε3+ε2/ε2) and POAG, compared with participants with Apo E ε3/3, with ORs of 0.91 (95% CI, 0.66 to 1.25; P = 0.543) and 1.08 (95% CI, 0.74 to 1.57; P = 0.694), respectively. In the subgroup analysis by ethnicity, source of controls, genotyping methods, Hardy-Weinberg equilibrium or not, or type of the POAG, still no obvious associations were found.ConclusionsThis meta-analysis suggests that Apo E ε2/ε3/ε4 polymorphisms may not be associated with the risk of POAG. However, well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

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Association of Apolipoprotein E Polymorphisms With Normal Tension Glaucoma in a Chinese Population

Abstract: Our findings suggest that the APOE epsilon 4 allele confers a protective effect against NTG, whereas the APOE promoter polymorphisms do not contribute to POAG risk. However, the APOE -219G carriers tended to have later-onset POAG.

Cited by 55 publications

References 39 publications

Neurodegenerative Genes Polymorphisms of the -491A/TAPOE, the -877T/CAPPand the Risk of Primary Open-angle Glaucoma in the Polish Population

Neurodegenerative Genes Polymorphisms of the -491A/TAPOE, the -877T/CAPPand the Risk of Primary Open-angle Glaucoma in the Polish Population

Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis

Lack of Association of Apolipoprotein E (Apo E) ε2/ε3/ε4 Polymorphisms with Primary Open-Angle Glaucoma: A Meta-Analysis from 1916 Cases and 1756 Controls

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