Association of Arterial Stiffness Indexes, Determined From Digital Volume Pulse Measurement and Cardiovascular Risk Factors in Chronic Kidney Disease

Wang, Ming Cheng; Wu, An‐Bang; Cheng, Meng; Chen, Ju Yi; Ho, Chen Hsun; Tsai, Wei Chuan

doi:10.1038/ajh.2010.266

Cited by 11 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22) CI, derived from our photoplethysmography system, may be clinically useful for evaluating arterial stiffness of small to medium sized arteries. 14,15) We showed that both large and small arterial stiffening occurs in pre-DM patients in the current study. In Table III of our study, we found that the HOMA index, rather than fasting glucose and HbA 1C , was an independent determinant for CI after adjusting for important confounders.…”

Section: Discussionmentioning

confidence: 80%

“…14,15) The stiffness index (SI), calculated from the digital volume pulse (DVP) measured by photoplethysmography, is an index of wave refl ections and also an acceptable marker for large arterial stiffness. 16,17) According to the 2010 American Diabetes Association (ADA) guideline for diagnosis and classifi cation of DM, 18) pre-DM patients have a HbA 1C level between 5.7% to 6.4%.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

et al. 2013

Self Cite

View full text Add to dashboard Cite

SummaryPremature arteriosclerosis may be one of the mechanisms linking pre-diabetes mellitus (pre-DM) and cardiovascular disease. We sought to characterize premature arteriosclerosis in pre-DM using different arterial stiffness indices and to fi nd the independent contributors of this process. We recruited 33 patients without DM, 53 patients with pre-DM, and 34 subjects with DM. Both the compliance index (CI) and stiffness index (SI) were measured. Patients with pre-DM and DM had lower CI (3.8 ± 2.1 versus 5.2 ± 3.0 units; P < 0.05 and 3.6 ± 1.8 versus 5.2 ± 3.0 units; P < 0.05, respectively) and higher SI (8.0 ± 2.0 versus 6.7 ± 1.6 m/s; P < 0.01 and 9.4 ± 2.3 versus 6.7 ± 1.6 m/s; P < 0.001, respectively) than patients without DM. Using multivariate linear regression analysis, age, heart rate, and HOMA index were independent determinants for SI (whole model: R 2 = 0.47, P < 0.001), whereas male gender, hsCRP, and HOMA index were independent determinants for CI (whole model: R 2 = 0.34, P < 0.01). The HOMA index was an independent determinant for arterial stiffness. Increased insulin resistance may associate with increased arterial stiffness at peripheral arteries in pre-DM patients. (Int Heart J 2013; 54: 27-32)

show abstract

Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 99%

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…Schillaci et al reported that there was an inverse relationship exists between GFR and stiffness of both central and peripheral arteries in hypertensive patients with normal renal function 23 . Our previous work showed that decrease of CI-DVP was associated with the increase in number of cardiovascular risk factors and CI-DVP was independently associated with eGFR 11 . Tian et al suggested that peripheral artery disease, defined as ABI <0.9, was a marker to predict the loss of residual renal function in patients receiving peritoneal dialysis 7 .…”

Section: Discussionmentioning

confidence: 94%

“…Compliance index derived from digital volume pulse (CI-DVP), measuring the relationship between volume and pressure changes in fingertip, is a surrogate marker of local and peripheral arterial stiffness. Previous studies have shown that there were significant associations among arterial compliance, cardiovascular risk factors and renal function in CKD patients, among CI-DVP, insulin resistance and inflammatory marker in pre-diabetes patients, and between CI-DVP and waist circumference in patients with nonalcoholic fatty liver disease 8 - 11 .…”

Section: Introductionmentioning

confidence: 95%

Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease

Kuo

Yang

Lin³

et al. 2015

Int. J. Med. Sci.

Self Cite

View full text Add to dashboard Cite

Background: Compliance index derived from digital volume pulse (CI-DVP), measuring the relationship between volume and pressure changes in fingertip, is a surrogate marker of peripheral arterial stiffness. This study investigated if CI-DVP can predict renal function deterioration, cardiovascular events and mortality in patients with chronic kidney disease (CKD).Methods: In this prospective observational study, 149 CKD patients were included for final analysis. CI-DVP and brachial-ankle pulse wave velocity (baPWV) were measured, decline in renal function was assessed by the estimated glomerular filtration rate (eGFR) slope. Composite renal and cardiovascular outcomes were evaluated, including ≥50% eGFR decline, start of renal replacement therapy, and major adverse events.Results: Patients in CKD stages 3b to 5 had higher baPWV and lower CI-DVP values than those in patients with CKD stages 1 to 3a. Stepwise multivariate linear regression analysis showed that lower CI-DVP (p =0.0001) and greater proteinuria (p =0.0023) were independent determinants of higher eGFR decline rate. Multivariate Cox regression analysis revealed that CI-DVP (HR 0.68, 95% CI 0.46-1.00), baseline eGFR (HR 0.96, 95% CI 0.94-0.98) and serum albumin (HR 0.17, 95% CI 0.07-0.42) were independent predictors for composite renal and cardiovascular outcomes.Conclusions: Compliance index, CI-DVP, was significantly associated with renal function decline in patients with CKD. A higher CI-DVP may have independent prognostic value in slower renal function decline and better composite renal and cardiovascular outcomes in CKD patients.

show abstract

“…CKD is associated with progressive changes in central arterial extracellular matrix composition and collagen fiber configuration 33 and increased arterial stiffness. [34][35][36] Changes in the matrix structures of venous walls, however, have not been studied in CKD patients until our recent report describing qualitative patterns of collagen configuration. 7 This study has expanded on our previous qualitative description of collagen fiber patterns, 7 by quantifying two components of upper-extremity vascular fiber configuration, namely, anisotropy index and orientation angle.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease

et al. 2018

View full text Add to dashboard Cite

show abstract

Association of Arterial Stiffness Indexes, Determined From Digital Volume Pulse Measurement and Cardiovascular Risk Factors in Chronic Kidney Disease

Abstract: Our data demonstrate a significant association between CI-DVP, a new surrogate marker of arterial stiffness different from PWV, and renal function and cardiovascular risk factors in CKD patients.

Cited by 11 publications

References 32 publications

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease

Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease

Contact Info

Product

Resources

About