Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China

BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas

“…Also, the total lack of asbestos exposure and BAP1 mutations in the women included in our series (see Table 1) suggests that there might be additional factors causing peritoneal mesotheliomas aside from asbestos, probably through alternate pathogenic mechanisms as was recently proposed in a study in an Eastern China population. 26 Loss of nuclear localization is required for BAP1mediated tumor suppressor activity 1 ; however, there was no perfect match between the presence of a CN deletion or mutation and the loss of BAP1 nuclear expression, suggesting a heterozygous inactivation of BAP1 in those cases that retained some nuclear expression. Besides, CN loss or mutation did not explain all the cases with loss of BAP1 nuclear expression, suggesting that additional mechanisms may be resulting in the inactivation of BAP1, such as genomic rearrangements 14 or epigenetic inactivation.…”

Mesothelioma: recent highlights

“…As we were reviewing the accuracy of the diagnoses of mesothelioma in Eastern China (5,52) in mesotheliomas linked to inherited germline BAP1 mutations, to environmental exposure occurring since birth, radiation or to other yet unknown carcinogens (13,39). In the absence of occupational asbestos exposure, the expected M:F ratio is close to 1:1 (12).…”

Hand‐spinning chrysotile exposure and risk of malignant mesothelioma: A case–control study in Southeastern China

“…For instance, estimated incidence of mesothelioma between 2008 and 2012 is 1.5 cases per million in China. 14 year cumulative deaths during 1994-2008 in China were only 5,107, however, this estimation is likely under-reported. 15 The age-standardized death rate was 0.8 per million people, which may be biased as the estimation is subject to poor registration procedure of mesothelioma in China.…”

“…Although nationwide data on mesothelioma in China are scarce due to the lack of a nationwide mesothelioma register, a number of epidemiological investigations on mesothelioma have been reported. For instance, estimated incidence of mesothelioma between 2008 and 2012 is 1.5 cases per million in China . Estimated 15‐year cumulative deaths during 1994–2008 in China were only 5,107, however, this estimation is likely under‐reported .…”