2001
DOI: 10.1164/ajrccm.163.6.2001101
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Association of Asthma with β2-Adrenergic Receptor Gene Polymorphism and Cigarette Smoking

Abstract: Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma. We hypothesize that there is an interaction effect on asthma between the beta(2)AR gene polymorphisms and cigarette smoking. A case-control study was conducted in 128 asthma cases and 136 control individu… Show more

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Cited by 95 publications
(63 citation statements)
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“…Our results are consistent with a Chinese study that reported an association between the Arg16 allele and asthma in cigarette smokers (Wang et al 2001). However, a study of childhood asthma found an association with the Glu27 allele (Hopes et al 1998), and another study found nocturnal asthma to be associated with the Gly16 allele .…”
Section: Discussionsupporting
confidence: 93%
“…Our results are consistent with a Chinese study that reported an association between the Arg16 allele and asthma in cigarette smokers (Wang et al 2001). However, a study of childhood asthma found an association with the Glu27 allele (Hopes et al 1998), and another study found nocturnal asthma to be associated with the Gly16 allele .…”
Section: Discussionsupporting
confidence: 93%
“…The modifying role of smoking on the association between ADRB2 Arg16Gly and asthma/ wheeze was reported previously for adults, 7 and existing data suggest that both smoking and these functional SNPs modulate β2AR density and activity 13,23 ; therefore, our analyses were based on specified a priori hypotheses. In this setting, we do not consider it appropriate to disregard previous information on the biology of β2AR expression and to adjust the P values for testing a set of selected a priori hypotheses.…”
Section: Discussionmentioning
confidence: 95%
“…To date, 1 study has reported the joint effects of functional variants in ADRB2 and personal active smoking on asthma. Among Chinese adults, Wang et al 7 found that individuals who were homozygous for the Arg16 allele were at an increased risk for asthma only in smokers. Whether exposure to maternal smoking in utero or secondhand smoke (SHS) in childhood modifies the effect of these functional ADRB2 genetic variants on wheezing is yet to be determined.…”
Section: Introductionmentioning
confidence: 99%
“…With the tremendous advances being made in molecular genetic technology, researchers are now in the position to investigate the role candidate genes play with environmental factors in modifying disease risk and severity. For example, gene-environment interactions have been reported recently for alcoholism (Matsuo et al 2001), asthma (Wang et al 2001) and lung cancer (Zhou et al 2001). For these types of studies, gene-mapping techniques that assume disease susceptibility is principally due to one genetic locus will not suffice.…”
Section: Introductionmentioning
confidence: 99%