Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men

Abstract

The role of asymptomatic infections caused by Chlamydia trachomatis in male infertility and the efficacy of antibiotics in the treatment of this condition are not yet definitely determined. A total of 165 infertile males having abnormal semen parameters (study group) as well as 165 healthy fertile men (control group) were included. Semen samples were taken from all participants and after analysing for semen parameters, undergone real-time PCR, and reactive oxygen species (ROS) as well as total antioxidant capacity (TAC) assays. Infected individuals of study group were treated with antibiotic. One month after the treatment completion, second semen samples were taken and undergone all the tests mentioned. The frequency of C. trachomatis was significantly higher in the infertile men compared with the fertile ones (4.2% vs 0.6%). Most of the semen parameters were improved and reached their normal range, the level of TAC elevated and ROS level as well as ROS/TAC ratio reduced after antibiotic treatment. Moreover, wives of three infected infertile men (42.9%) became pregnant 4 months after the treatment completion. Our data suggest that asymptomatic infection caused by C. trachomatis is correlated with male infertility and antibiotic therapy can improve the semen quality and fairly treat the male infertility.

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

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HIV, HPV and Chlamydia trachomatis: impacts on male fertility

“…There was an exception in the progressive motile class A, which had only a 42.9% improvement. There were no statistically significant differences in volume, pH, viscosity, and non-progressive motility (class C) in the initial and post-treatment analyzes ( Ahmadi et al , 2018 ).…”

“…Ahmadi MH et al (2018) Concentration (milions/ml), total count, progressive motility A, progressive motility B, total progressive motility (A + B + C) and morphology.…”

Leukocytospermia is not an informative predictor of positive semen culture in infertile men: results from a validation study of available guidelines

“…Semen pathogens have been associated with decreased sperm concentration and progressive motility, lower chromatin condensation and a higher rate of protamine1/protamine2 ratio abnormalities ( Zeyad et al , 2018 ). In the clinical setting, asymptomatic C. trachomatis infection is found to be more common in infertile men than in fertile controls, and subsequent antibiotic treatment is associated with improved semen parameters and reduced levels of reactive oxygen species in the infertile cohort ( Ahmadi et al , 2018b ). Similar results are observed in asymptomatic infertile men with evidence of seminal Mycoplasma genitalium ( Ahmadi et al , 2018a ).…”