Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses

Schans, Jurjen van der; Çiçek, Rukiye; Vries, Tjalling W. de; Hak, Eelko; Hoekstra, Pieter J.

doi:10.1016/j.neubiorev.2017.01.011

Cited by 141 publications

(107 citation statements)

References 41 publications

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“…Most studies regarding atopic diseases and child behaviour have investigated the association with ADHD, rather than other forms of altered child behaviour, and positive associations have been found both for asthma and AD. 44 In line with previous research, we found a significant association between AD symptoms and "probable" hyperactivity/inattention disorder. In general, risk estimates were higher in the sensitivity analysis evaluating ORs for "probable" hyperactivity/inattention disorder as compared to ORs for "possible/ probable" hyperactivity/inattention disorder.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Ballardini

Kramer

Oken

et al. 2019

Clin Experimental Allergy

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Background Conflicting findings from studies evaluating associations of allergic disease with child behaviour require longitudinal studies to resolve. Objective To estimate the magnitude of associations of atopic dermatitis (AD) in infancy, and symptoms of asthma and AD at 6.5 years, with child behaviour at 6.5 years. Methods Secondary cohort analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT). PROBIT enrolled 17 046 infants at birth and followed them up at 6.5 years (n = 13 889). Study paediatricians collected data on infantile AD at repeated follow‐up examinations during the first year of life. At 6.5 years, paediatricians performed skin prick tests and parents reported asthma and AD symptoms during the prior year. In addition, parents and teachers completed the Strength and Difficulties Questionnaire, which includes scales on hyperactivity/inattention, emotional problems, conduct problems, peer problems and prosocial behaviours. Results Physician‐diagnosed AD in the first year of life was not associated with increased risk for behavioural problems at 6.5 years. Emotional problems at 6.5 years were more common among children with AD symptoms (OR: 2.24, 95% CI: 1.62‐3.12) and asthma symptoms (OR: 1.45; 95% CI: 1.07‐1.96) during the past year at 6.5 years and ORs for children with symptoms of more severe AD and asthma were also higher. AD in the past year was also associated with probable hyperactivity/inattention disorder at 6.5 years (OR: 2.05; 95% CI: 1.09‐3.84). Other subscales of the SDQ were not related to asthma or AD symptoms during the past year. Conclusions and clinical relevance Children with AD symptoms were at higher risk for concomitant hyperactivity/inattention and emotional disorder, and children with asthma symptoms were at higher risk of having concomitant emotional problems. However, AD during infancy did not predict childhood behaviours.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Ballardini

Kramer

Oken

et al. 2019

Clin Experimental Allergy

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“…They found that ADHD patients were more likely to have asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis in comparison to the non-ADHD subjects from the population. Similar results were found by Schans et al [38], performing a systematic review and meta-analysis examining the co-occurrence of atopy and ADHD. They found a higher presence of asthma, eczema, and rhinitis in ADHD patients when compared to a control population.…”

Section: Comorbidity With Inflammatory and Autoimmune Disorderssupporting

confidence: 88%

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

Leffa

Torres

Rohde

2018

Neuroimmunomodulation

129

103

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Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that impairs quality of life in social, academic, and occupational contexts for both children and adults. Although a strong neurobiological basis has been demonstrated, the pathophysiology of ADHD is still poorly understood. Among the proposed mechanisms are glial activation, neuronal damage and degeneration, increased oxidative stress, reduced neurotrophic support, altered neurotransmitter metabolism, and blood-brain barrier disruption. In this way, a potential role of inflammation has been increasingly researched. However, evidence for the involvement of inflammation in ADHD is still scarce and comes mainly from (1) observational studies showing a strong comorbidity of ADHD with inflammatory and autoimmune disorders; (2) studies evaluating serum inflammatory markers; and (3) genetic studies. A co-occurrence of ADHD with inflammatory disorders has been demonstrated in a large number of subjects, suggesting a range of underlying mechanisms such as an altered immune response, common genetics, and environmental links. The evaluation of serum inflammatory markers has provided mixed results, likely due to the small sample sizes and high heterogeneity between biomarkers. However, there is evidence that increased inflammation during the early development may be a risk factor for ADHD symptoms. Although genetic studies have demonstrated a potential role for inflammation in this disorder, there is no clear evidence. To sum up, inflammation may be an important mechanism in ADHD pathophysiology, but more studies are still needed for a more precise conclusion.

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“…Altered blood cell counts were associated with genetic liability for all disorders. Many psychiatric disorders previously have been associated with allergic or inflammatory states (35–37), such as asthma (38) and atopic diseases (39, 40) but it is unclear whether high inflammatory states are on the causal pathway to disorder manifestation or the result of comorbid and confounding behaviours associated with the disease, such as restricted diet, overweight, risky behaviours or medication. Our results support the possibility that altered blood cell counts could be a consequence of the disorder, but we cannot rule out contributions of horizontal pleiotropic effects.…”

Section: Discussionmentioning

confidence: 99%

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

Leppert

Millard

Riglin

et al. 2019

Preprint

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25Psychiatric disorders are highly heritable and associated with a wide variety of social 26 adversity and physical health problems. Using genetic liability (rather than phenotypic 27 measures of disease) as a proxy for psychiatric disease risk can be a useful alternative 28 3 50 AUTHOR SUMMARY 51 Psychiatric disorders are associated with a wide range of adverse health, social and 52 economic problems. Our study investigates the association of genetic risk for five 53 common psychiatric disorders with socio-demographics, lifestyle and health of about 54 330,000 participants in the UK Biobank using a systematic, hypothesis-free approach. 55 We found that genetic risk for attention deficit/hyperactivity disorder (ADHD) and 56 bipolar disorder were most strongly associated with lifestyle factors, such as time of 57 first sexual intercourse and educational attainment. Genetic risks for autism spectrum 58 disorder and schizophrenia were associated with altered blood cell counts and time 59 playing computer games, respectively. Increased genetic risk for depression was 60 associated with other mental health outcomes such as neuroticism and irritability. In 61 general, our results suggest that genetic risk for psychiatric disorders associates with 62 a range of health and lifestyle traits that were measured in adulthood, in individuals 63 from the general population who do not necessarily present with a psychiatric disorder 64 diagnosis. However, it is important to note that these associations aren't necessary 65 causal but can themselves be influenced by other factors, like socio-economic factors 66 and selection into the cohort. The findings inform future hypotheses to be tested using 67 causally informative designs. 4 68 101 common psychiatric disorders -attention-deficit/ hyperactivity disorder (ADHD), 102 autism spectrum disorder (ASD), schizophrenia (SCZ), major depression (MDD) and 103 bipolar disorder (BP) -with a wide range of socio-demographic, lifestyle, physical and 104 mental health outcomes in UK Biobank, using the systematic hypothesis-free MR-105 pheWAS approach. 6 106 RESULTS 107In total 334,976 participants of white British ancestry in UK Biobank were included in 108 this study with an average age of 56 (standard deviation [SD]=8) years. A descriptive 109 overview of selected UK Biobank study sample characteristics is given in Figure 1A. 110The UK Biobank participants are known to be more educated and healthier than the 111 average UK population which is reflected in the high percentage of people with a 112 university degree (47%) and low prevalence of current smoking (10%) in the sample, 113 which is comparable to the full UK Biobank release (9). Furthermore, 34% of 114 participants reported to have seen a general practitioner and 11% a psychiatrist for 115 nerves, anxiety, tension or depression but there are few cases of schizophrenia 116 (n=132), ADHD (n=71), ASD (n=143) or bipolar disorder (n=439). An overview of UK 117 Biobank phenotype categories is given in Figure 1B. 118 DISORDER SP...

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Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses

Cited by 141 publications

References 41 publications

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

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